Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Peter Vermaelen"'
Autor:
Patrick Schöffski, Maria Debiec-Rychter, Jonathan A. Fletcher, Christophe M. Deroose, Peter Vermaelen, Jasmien Wellens, Thomas Van Looy, Lori Friedman, Haifu Li, Raf Sciot, Agnieszka Wozniak, Giuseppe Floris
Purpose: Oncogenic signaling in gastrointestinal stromal tumors (GIST) is sustained via PI3K/AKT pathway. We used a panel of six GIST xenograft models to assess efficacy of GDC-0941 as single agent or in combination with imatinib (IMA).Experimental D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc6ce57c81848b572246907c98d9dedf
https://doi.org/10.1158/1078-0432.c.6522002
https://doi.org/10.1158/1078-0432.c.6522002
Autor:
Patrick Schöffski, Maria Debiec-Rychter, Jonathan A. Fletcher, Christophe M. Deroose, Peter Vermaelen, Jasmien Wellens, Thomas Van Looy, Lori Friedman, Haifu Li, Raf Sciot, Agnieszka Wozniak, Giuseppe Floris
PDF file - 566K, Xenograft tumor volume assessment, combined for all models. Tumor volume is expressed in percentage, as ratio between time point x baseline. Data are presented for all models (A), based on PTEN protein expression (B), and PTEN status
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4053728065e986fba8d14c87eb95474c
https://doi.org/10.1158/1078-0432.22450709.v1
https://doi.org/10.1158/1078-0432.22450709.v1
Autor:
Patrick Schöffski, Maria Debiec-Rychter, Jonathan A. Fletcher, Christophe M. Deroose, Peter Vermaelen, Jasmien Wellens, Thomas Van Looy, Lori Friedman, Haifu Li, Raf Sciot, Agnieszka Wozniak, Giuseppe Floris
PDF file - 1222K, PTEN protein expression. Strong expression of PTEN was observed in GIST-DFR (A), GIST-BOE (B), GIST882 (C) and GIST48 (D). In GIST-PSW (E) and GIST882Ly (F) the majority of the tumor cells were PTEN negative, only scattered cells sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702fb40df2492e413700593050811bca
https://doi.org/10.1158/1078-0432.22450712
https://doi.org/10.1158/1078-0432.22450712
Autor:
Patrick Schöffski, Maria Debiec-Rychter, Jonathan A. Fletcher, Christophe M. Deroose, Peter Vermaelen, Jasmien Wellens, Thomas Van Looy, Lori Friedman, Haifu Li, Raf Sciot, Agnieszka Wozniak, Giuseppe Floris
PDF file - 58K, Xenografts used in GDC-0941 efficacy experiments. All mice were subcutaneously transplanted with tumor fragment on both sides.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a031480f6701c20c82183656b2cf51c0
https://doi.org/10.1158/1078-0432.22450694.v1
https://doi.org/10.1158/1078-0432.22450694.v1
Autor:
Patrick Schöffski, Maria Debiec-Rychter, Jonathan A. Fletcher, Christophe M. Deroose, Peter Vermaelen, Jasmien Wellens, Thomas Van Looy, Lori Friedman, Haifu Li, Raf Sciot, Agnieszka Wozniak, Giuseppe Floris
PDF file - 4757K, Western blotting showing KIT oncogenic signaling cascade. Three different tumor lysates were analyzed per treatment group.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f5ec6d0d95b65ea0085d33eac2c267
https://doi.org/10.1158/1078-0432.22450703
https://doi.org/10.1158/1078-0432.22450703
Autor:
Patrick Schöffski, Maria Debiec-Rychter, Jonathan A. Fletcher, Christophe M. Deroose, Peter Vermaelen, Jasmien Wellens, Thomas Van Looy, Lori Friedman, Haifu Li, Raf Sciot, Agnieszka Wozniak, Giuseppe Floris
PDF file - 1683K, Representative micro-PET images from GIST-PSW (A) and GIST-DFR (B) mice treated with IMA or GDC+IMA are shown. Scans were perfromed at baseline, week four (end of the treatment) and weeks six and eight - during treatment discontinua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46427f48b4165ad538b8e17205e0fbd0
https://doi.org/10.1158/1078-0432.22450706
https://doi.org/10.1158/1078-0432.22450706
Autor:
Patrick Schöffski, Maria Debiec-Rychter, Jonathan A. Fletcher, Christophe M. Deroose, Peter Vermaelen, Jasmien Wellens, Thomas Van Looy, Lori Friedman, Haifu Li, Raf Sciot, Agnieszka Wozniak, Giuseppe Floris
PDF file - 2344K, Representative images of control tumors from GIST882Ly (A-E) and GIST-DFR (F-J). The H&E staining was shown to illustrate tumor morphology (A, F). Expression of KIT (B, G), ANO1 (C, H), ETV1 (D, I) and CD44 (E, J) were studied to fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a82c557fcdfa6f7fe841239d64e0994
https://doi.org/10.1158/1078-0432.22450715
https://doi.org/10.1158/1078-0432.22450715
Autor:
Patrick Schöffski, Maria Debiec-Rychter, Jonathan A. Fletcher, Christophe M. Deroose, Peter Vermaelen, Jasmien Wellens, Thomas Van Looy, Lori Friedman, Haifu Li, Raf Sciot, Agnieszka Wozniak, Giuseppe Floris
PDF file - 84K, Xenograft models characterization.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e5551ff1f48f5c9ccb8b60133d402e
https://doi.org/10.1158/1078-0432.22450697
https://doi.org/10.1158/1078-0432.22450697
Autor:
Patrick Schöffski, Maria Debiec-Rychter, Jonathan A. Fletcher, Christophe M. Deroose, Peter Vermaelen, Jasmien Wellens, Thomas Van Looy, Lori Friedman, Haifu Li, Raf Sciot, Agnieszka Wozniak, Giuseppe Floris
PDF file - 240K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::def74e37ff2ccb8b5c3ae845f7c2cc6a
https://doi.org/10.1158/1078-0432.22450700
https://doi.org/10.1158/1078-0432.22450700
Autor:
Michel Koole, Peter Vermaelen, Jana Somers, Geert Verleden, Dirk Van Raemdonck, Shana Wauters, Koen Van Laere, Johannes van Loon
Publikováno v:
Journal of Surgical Research. 180:343-348
Because brain death (BD)-related donor lung injury is still poorly understood, a reliable mouse model can help in understanding the immunologic mechanisms behind this lung injury. The purpose of our study was to validate BD in mice using small-animal