Llama-derived single domain antibodies to build multivalent, superpotent and broadened neutralizing anti-viral molecules.

Autor: Anna Hultberg, Nigel J Temperton, Valérie Rosseels, Mireille Koenders, Maria Gonzalez-Pajuelo, Bert Schepens, Lorena Itatí Ibañez, Peter Vanlandschoot, Joris Schillemans, Michael Saunders, Robin A Weiss, Xavier Saelens, José A Melero, C Theo Verrips, Steven Van Gucht, Hans J de Haard

Publikováno v: PLoS ONE, Vol 6, Iss 4, p e17665 (2011)

For efficient prevention of viral infections and cross protection, simultaneous targeting of multiple viral epitopes is a powerful strategy. Llama heavy chain antibody fragments (VHH) against the trimeric envelope proteins of Respiratory Syncytial Vi

Externí odkaz: https://doaj.org/article/be706cebe8694a689e58995df755499f

Anti-TTR Nanobodies Allow the Identification of TTR Neuritogenic Epitope Associated with TTR-Megalin Neurotrophic Activities

Autor: João R. Gomes, Renata Nogueira, Hugo R. Soares, Angela Wittelsberger, Sandra Macedo-Ribeiro, A. Teixeira, Catelijne Stortelers, Peter Vanlandschoot, Maria João Saraiva, Zsuzsa Sárkány, Inês Cabrito

Publikováno v: ACS chemical neuroscience. 10(1)

Transthyretin (TTR) has intrinsic neurotrophic physiological activities independent from its thyroxine ligands, which involve activation of signaling pathways through interaction with megalin. Still, the megalin binding motif on TTR is unknown. Nanob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed37889310593c925810d6f34122958c
https://pubmed.ncbi.nlm.nih.gov/30346709

Delivery of an anti-transthyretin Nanobody to the brain through intranasal administration reveals transthyretin expression and secretion by motor neurons

Autor: Angela Wittelsberger, João R. Gomes, A. Teixeira, Susete Costelha, Catelijne Stortelers, Hugo R. Soares, Peter Vanlandschoot, Maria João Saraiva, Inês Cabrito

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Transthyretin (TTR) is a transport protein of retinol and thyroxine in serum and CSF, which is mainly secreted by liver and choroid plexus, and in smaller amounts in other cells throughout the body. The exact role of TTR and its specific expression i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a9f2d0f2a70c41d628940f07cd8078
https://pubmed.ncbi.nlm.nih.gov/29527688

Nanobodies®: New ammunition to battle viruses

Autor: Peter Vanlandschoot, Erik Depla, Bert Schepens, Catelijne Stortelers, Lorena Itatí Ibañez, Xavier Saelens, Els Beirnaert

Publikováno v: Antiviral Research. 92:389-407

In 1989, a new type of antibody was identified, first in the sera of dromedaries and later also in all other species of the Camelidae family. These antibodies do not contain a light chain and also lack the first constant heavy domain. Today it is sti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d66bf4201ada4780c0bde2ef0cc5339a
https://doi.org/10.1016/j.antiviral.2011.09.002

CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells

Autor: David Maussang, Ken Y. Chow, Maria Gonzalez-Pajuelo, Dominique Schols, Martine J. Smit, Hans Ulrichts, Michael A. Saunders, Rob Leurs, Sindi De Vrieze, Theo Verrips, Peter Vanlandschoot, Wesly Vandevelde, Benedikte Serruys, Christophe Blanchetot, Hans de Haard, Leontien Bosch, Sven Jähnichen

Publikováno v: Jänichen, S, Blanchelot, C, Maussang Detaille, D A B, Gonzalez-Pajuelo, M, Chow, Y C K, Bosch, L, De Vrieze, S, Serruys, B, Ulrichts, H, Vandevelde, W, Saunders, M, De Haard, H J, Schols, D, Leurs, R, Vanlandschoot, P, Verrips, T & Smit, M J 2010, ' CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells ', Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 47, pp. 20565-20570 . https://doi.org/10.1073/pnas.1012865107
Proceedings of the National Academy of Sciences of the United States of America, 107(47), 20565-20570. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 107(47), 20565-20570. National Acad Sciences

The important family of G protein-coupled receptors has so far not been targeted very successfully with conventional monoclonal antibodies. Here we report the isolation and characterization of functional VHH-based immunoglobulin single variable domai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99c35a021a1795ee478f5e7f09799d3e
https://doi.org/10.1073/pnas.1012865107