Pragmatic randomized controlled trials: strengthening the concept through a robust international collaborative network: PRIME-9—Pragmatic Research and Innovation through Multinational Experimentation

Autor: Elmir Omerovic, Mark Petrie, Björn Redfors, Stephen Fremes, Gavin Murphy, Guillaume Marquis-Gravel, Alexandra Lansky, Eric Velazquez, Divaka Perera, Christopher Reid, Julian Smith, Peter van der Meer, Eric Lipsic, Peter Juni, John McMurray, Johann Bauersachs, Lars Køber, Jean L. Rouleau, Torsten Doenst

Publikováno v: Trials, Vol 25, Iss 1, Pp 1-13 (2024)

Abstract In an era focused on value-based healthcare, the quality of healthcare and resource allocation should be underpinned by empirical evidence. Pragmatic clinical trials (pRCTs) are essential in this endeavor, providing randomized controlled tri

Externí odkaz: https://doaj.org/article/24d79e7c4c284da99308af6fa57f3145

Intravenous ferric carboxymaltose for iron repletion following acute heart failure in patients with and without diabetes: a subgroup analysis of the randomized AFFIRM-AHF trial

Autor: Giuseppe Rosano, Piotr Ponikowski, Cristiana Vitale, Stefan D. Anker, Javed Butler, Vincent Fabien, Gerasimos Filippatos, Bridget-Anne Kirwan, Iain C. Macdougall, Marco Metra, Frank Ruschitzka, Vasuki Kumpeson, Udo-Michael Goehring, Peter van der Meer, Ewa A. Jankowska, the AFFIRM-AHF investigators

Publikováno v: Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-12 (2023)

Abstract Background In AFFIRM-AHF, treatment of iron deficiency with intravenous ferric carboxymaltose (FCM) reduced the risk of heart failure (HF) hospitalization and improved quality of life (QoL) vs placebo in patients stabilized following an acut

Externí odkaz: https://doaj.org/article/351511ae7e4e47f08ac3be599fe42e1f

IGF-1 boosts mitochondrial function by a Ca2+ uptake-dependent mechanism in cultured human and rat cardiomyocytes

Autor: Pablo Sánchez-Aguilera, Camila López-Crisosto, Ignacio Norambuena-Soto, Christian Penannen, Jumo Zhu, Nils Bomer, Matijn F. Hoes, Peter Van Der Meer, Mario Chiong, B. Daan Westenbrink, Sergio Lavandero

Publikováno v: Frontiers in Physiology, Vol 14 (2023)

A physiological increase in cardiac workload results in adaptive cardiac remodeling, characterized by increased oxidative metabolism and improvements in cardiac performance. Insulin-like growth factor-1 (IGF-1) has been identified as a critical regul

Externí odkaz: https://doaj.org/article/dd5985a3229f44acb011a62b508ee8b7

Tree mode of death and mortality risk factors across Amazon forests

Autor: Adriane Esquivel-Muelbert, Oliver L. Phillips, Roel J. W. Brienen, Sophie Fauset, Martin J. P. Sullivan, Timothy R. Baker, Kuo-Jung Chao, Ted R. Feldpausch, Emanuel Gloor, Niro Higuchi, Jeanne Houwing-Duistermaat, Jon Lloyd, Haiyan Liu, Yadvinder Malhi, Beatriz Marimon, Ben Hur Marimon Junior, Abel Monteagudo-Mendoza, Lourens Poorter, Marcos Silveira, Emilio Vilanova Torre, Esteban Alvarez Dávila, Jhon del Aguila Pasquel, Everton Almeida, Patricia Alvarez Loayza, Ana Andrade, Luiz E. O. C. Aragão, Alejandro Araujo-Murakami, Eric Arets, Luzmila Arroyo, Gerardo A. Aymard C., Michel Baisie, Christopher Baraloto, Plínio Barbosa Camargo, Jorcely Barroso, Lilian Blanc, Damien Bonal, Frans Bongers, René Boot, Foster Brown, Benoit Burban, José Luís Camargo, Wendeson Castro, Victor Chama Moscoso, Jerome Chave, James Comiskey, Fernando Cornejo Valverde, Antonio Lola da Costa, Nallaret Davila Cardozo, Anthony Di Fiore, Aurélie Dourdain, Terry Erwin, Gerardo Flores Llampazo, Ima Célia Guimarães Vieira, Rafael Herrera, Eurídice Honorio Coronado, Isau Huamantupa-Chuquimaco, Eliana Jimenez-Rojas, Timothy Killeen, Susan Laurance, William Laurance, Aurora Levesley, Simon L. Lewis, Karina Liana Lisboa Melgaço Ladvocat, Gabriela Lopez-Gonzalez, Thomas Lovejoy, Patrick Meir, Casimiro Mendoza, Paulo Morandi, David Neill, Adriano José Nogueira Lima, Percy Nuñez Vargas, Edmar Almeida de Oliveira, Nadir Pallqui Camacho, Guido Pardo, Julie Peacock, Marielos Peña-Claros, Maria Cristina Peñuela-Mora, Georgia Pickavance, John Pipoly, Nigel Pitman, Adriana Prieto, Thomas A. M. Pugh, Carlos Quesada, Hirma Ramirez-Angulo, Simone Matias de Almeida Reis, Maxime Rejou-Machain, Zorayda Restrepo Correa, Lily Rodriguez Bayona, Agustín Rudas, Rafael Salomão, Julio Serrano, Javier Silva Espejo, Natalino Silva, James Singh, Clement Stahl, Juliana Stropp, Varun Swamy, Joey Talbot, Hans ter Steege, John Terborgh, Raquel Thomas, Marisol Toledo, Armando Torres-Lezama, Luis Valenzuela Gamarra, Geertje van der Heijden, Peter van der Meer, Peter van der Hout, Rodolfo Vasquez Martinez, Simone Aparecida Vieira, Jeanneth Villalobos Cayo, Vincent Vos, Roderick Zagt, Pieter Zuidema, David Galbraith

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

Tree mortality has been shown to be the dominant control on carbon storage in Amazon forests, but little is known of how and why Amazon forest trees die. Here the authors analyse a large Amazon-wide dataset, finding that fast-growing species face gre

Externí odkaz: https://doaj.org/article/11ce38c0c2844f15a6cd0f2d40122220

Towards a Better Understanding of Genotype–Phenotype Correlations and Therapeutic Targets for Cardiocutaneous Genes: The Importance of Functional Studies above Prediction

Autor: Mathilde C. S. C. Vermeer, Daniela Andrei, Luisa Marsili, J. Peter van Tintelen, Herman H. W. Silljé, Maarten P. van den Berg, Peter van der Meer, Maria C. Bolling

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 18, p 10765 (2022)

Genetic variants in gene-encoding proteins involved in cell–cell connecting structures, such as desmosomes and gap junctions, may cause a skin and/or cardiac phenotype, of which the combination is called cardiocutaneous syndrome. The cardiac phenot

Externí odkaz: https://doaj.org/article/fff995654c4f4d3cb850ab8b35b514f5