Výsledky vyhledávání - "Peter Van, der Ark"

Akademický článek

Characterization of the central nervous system penetrant and selective purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder

Autor: Kasper Recourt, Peter de Boer, Peter van der Ark, Heike Benes, Joop M. A. van Gerven, Marc Ceusters, Luc van Nueten, Wayne C. Drevets, Anindya Bhatacharya, Michael Browning, Gabriel E. Jacobs

Publikováno v: Translational Psychiatry, Vol 13, Iss 1, Pp 1-11 (2023)

Abstract JNJ-54175446 is a selective purine P2X7 receptor (P2X7R) antagonist that attenuates microglial IL-1β/IL-18 release. In healthy volunteers, JNJ-54175446 suppressed peripheral interleukin (IL)-1β release, and attenuated dexamphetamine-induce

Externí odkaz: https://doaj.org/article/ce0f225410c64ac8b7a1ca0270900c52

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Concordance of Alzheimer’s Disease-Related Biomarkers Between Intraventricular and Lumbar Cerebrospinal Fluid in Idiopathic Normal Pressure Hydrocephalus

Autor: Heikki Lukkarinen, Aleksi Vanninen, Ina Tesseur, Darrel Pemberton, Peter Van Der Ark, Tarja Kokkola, Sanna-Kaisa Herukka, Tuomas Rauramaa, Mikko Hiltunen, Kaj Blennow, Henrik Zetterberg, Ville Leinonen

Publikováno v: Journal of Alzheimer's Disease. 91:305-319

Background: Alzheimer’s disease cerebrospinal fluid (CSF) biomarkers amyloid-β 1–42 (Aβ42), total tau (T-tau), and phosphorylated tau 181 (P-tau181) are widely used. However, concentration gradient of these biomarkers between intraventricular (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80f9975e1119cfe257b720f330080f22
https://doi.org/10.3233/jad-220652

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Time Trends of Cerebrospinal Fluid Biomarkers of Neurodegeneration in Idiopathic Normal Pressure Hydrocephalus

Publikováno v: Journal of Alzheimer's disease
Journal of Alzheimer's Disease

Background: Longitudinal changes in cerebrospinal fluid (CSF) biomarkers are seldom studied. Furthermore, data on biomarker gradient between lumbar (L-) and ventricular (V-) compartments seems to be discordant. Objective: To examine alteration of CSF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9be6580819357c40e83649ee69241ef
https://doi.org/10.3233/jad-201361

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EEG parameters as endpoints in epilepsy clinical trials - An expert panel opinion paper

Autor: Jeffrey, Buchhalter, Caroline, Neuray, Jocelyn Y, Cheng, O'Neill, D'Cruz, Alexandre N, Datta, Dennis, Dlugos, Jacqueline, French, Dietrich, Haubenberger, Joseph, Hulihan, Pavel, Klein, Robert W, Komorowski, Lynn, Kramer, Amélie, Lothe, Rima, Nabbout, Emilio, Perucca, Peter Van, der Ark

Publikováno v: Epilepsy Research. 187:107028

The lack of ideal measurement of treatment efficacy is a well acknowledged problem in the epilepsy community, both in clinical care and clinical trials. Whilst still the current gold-standard, self-reported seizure frequency significantly underestima

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ef57b1fe4441aef87096383913beac6
https://doi.org/10.1016/j.eplepsyres.2022.107028

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The effects of inhibition of fatty acid amide hydrolase (FAAH) by JNJ-42165279 in social anxiety disorder: a double-blind, randomized, placebo-controlled proof-of-concept study

Autor: Peter van der Ark, Mark E. Schmidt, Michael R. Liebowitz, Darrel J. Pemberton, Ziad S. Saad, James A. Palmer, W. Kyle Simmons, Wayne C. Drevets, Jennifer Grunfeld, Ilse Van Hove, Luc Van Nueten, Murray B. Stein

Publikováno v: Neuropsychopharmacology

JNJ-42165279 is a selective inhibitor of fatty acid amide hydrolase (FAAH), the enzyme responsible for the degradation of fatty acid amides (FAA) including anandamide (AEA), palmitoylethanolamide (PEA), and N-oleoylethanolamide (OEA). We assessed the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9ee0ea8e9b1f228efaa9c32c188497a
https://pubmed.ncbi.nlm.nih.gov/33070154

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Fatty Acid Amide Hydrolase Inhibition by JNJ-42165279: A Multiple-Ascending Dose and a Positron Emission Tomography Study in Healthy Volunteers

Autor: Sofie Celen, Jan de Hoon, Mark E. Schmidt, Guy Bormans, Stef Rassnick, Peter Zannikos, Darrel J. Pemberton, James A. Palmer, Andrey Postnov, Maarten van den Boer, Peter van der Ark, Koen Van Laere, Anne Van Hecken

Publikováno v: Clinical and Translational Science. 11:397-404

Inhibition of fatty acid amide hydrolase (FAAH) potentiates endocannabinoid activity and is hypothesized to have therapeutic potential for mood and anxiety disorders and pain. The clinical profile of JNJ-42165279, an oral selective FAAH inhibitor, wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a5623b06a2dde74d87eb0f9a974a0ea2
https://doi.org/10.1111/cts.12548

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The selective orexin-2 antagonist seltorexant (JNJ-42847922/MIN-202) shows antidepressant and sleep-promoting effects in patients with major depressive disorder

Autor: Kasper Recourt, Wayne C. Drevets, Joop M. A. van Gerven, Luc Van Nueten, Peter van der Ark, Peter de Boer, Remy Luthringer, Justine M. Kent, Gabriel E. Jacobs, Ilse Van Hove, Rob Zuiker

Publikováno v: Translational Psychiatry, Vol 9, Iss 1, Pp 1-10 (2019)
Translational Psychiatry
Translational Psychiatry, 9. NATURE PUBLISHING GROUP

Excessive arousal has a role in the pathophysiology of major depressive disorder (MDD). Seltorexant (JNJ-42847922/MIN-202) is a selective antagonist of the human orexin-2 receptor (OX2R) that may normalize excessive arousal and thereby attenuate depr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b141c2805c7bd8ee013ee094e36941
https://doi.org/10.1038/s41398-019-0553-z

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