Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Peter V.N. Bodine"'
Autor:
Takayuki Shiomi, Jeanine D'Armiento, Rajbir Kaur, Ralph T. Schermuly, Becky A. Mercer, Jie Sun, Isaac George, P. Christian Schulze, Susan Kwon, Peter V.N. Bodine, Piotr Sklepkiewicz
Publikováno v:
Circulation: Heart Failure. 8:362-372
Background— The Wnt/β-catenin signaling pathway plays a central role during cardiac development and has been implicated in cardiac remodeling and aging. However, the role of Wnt modulators in this process is unknown. In this study, we examined the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62c474f2337fcee6528a51582a92e9ce
https://doi.org/10.1161/circheartfailure.114.001274
https://doi.org/10.1161/circheartfailure.114.001274
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 118:117-124
Bazedoxifene (BZA), a new selective estrogen receptor modulator (SERM) was recently approved in Europe for the prevention and treatment of postmenopausal osteoporosis. Combination therapy using BZA and conjugated estrogens (CE) is currently in late s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7620055e9abcc82e3f70f435ee841016
https://doi.org/10.1016/j.jsbmb.2009.11.003
https://doi.org/10.1016/j.jsbmb.2009.11.003
Publikováno v:
Journal of Bone and Mineral Research. 11:806-819
Many osteoblastic cell lines are currently in use, but these have limitations either in terms of their relevance to adult human biology and disease or in terms of their suitability for biochemical and molecular analyses. Consequently, we undertook th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7b498c3ad4cd6ddd5a8c57fc23c9364
https://doi.org/10.1002/jbmr.5650110612
https://doi.org/10.1002/jbmr.5650110612
Autor:
Diane B. Hauze, Michael C. Sharp, Bheem M. Bhat, Paula Green, Colleen Milligan, Daniel M. Green, Jennifer Pirrello, Peter V.N. Bodine, Ronald L. Magolda, Adam M. Gilbert, Matthew D. Vera, Yogendra P. Kharode, Valerie E. Coleburn, Luciana De Araujo Felix, Mattew G. Bursavich, Nipa Alon, Jeanne J. Matteo, Jay Wrobel, Frederick J. Bex, Jeffrey C. Pelletier, Susan Lockhead, Joseph T. Lundquist, Richard J. Murrills, Ray Unwalla, Paul J. Yaworsky, Sally Selim, John F. Mehlmann, Ho-Sun Lam
Publikováno v:
Journal of Medicinal Chemistry. 52:6962-6965
A high-throughput screening campaign to discover small molecule leads for the treatment of bone disorders concluded with the discovery of a compound with a 2-aminopyrimidine template that targeted the Wnt beta-catenin cellular messaging system. Hit-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26eacb52fff02ace8eb134ea084fe282
https://doi.org/10.1021/jm9014197
https://doi.org/10.1021/jm9014197
Autor:
Barry S. Komm, Sadiq Hussain, Shannon L. O'Connell, John J. Wixted, Peter V.N. Bodine, Elise F. Morgan, David C. Ayers, Tripti Gaur, Jane B. Lian, Gary S. Stein
Publikováno v:
Journal of Cellular Physiology. 220:174-181
Genetic studies have identified a high bone mass of phenotype in both human and mouse when canonical Wnt signaling is increased. Secreted frizzled related protein 1 (sFRP1) is one of several Wnt antagonists and among the loss-of-function mouse models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ea567de6283314efecf74a7132f73b
https://doi.org/10.1002/jcp.21747
https://doi.org/10.1002/jcp.21747
Autor:
Ramesh A. Bhat, Rachelle L. Samuel, Jennifer L. Andrews, Peter V.N. Bodine, Frederick J. Bex, Valerie E. Coleburn, Richard J. Murrills, Bheem M. Bhat
Publikováno v:
Journal of Cellular Biochemistry. 106:887-895
Parathyroid hormone (PTH) activates multiple signaling pathways following binding to the PTH1 receptor in osteoblasts. Previous work revealed a discrepancy between cAMP stimulation and CRE reporter activation of truncated PTH peptides, suggesting tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffbd8ae7072806e8e44d9f5e416325cb
https://doi.org/10.1002/jcb.22057
https://doi.org/10.1002/jcb.22057
Autor:
Gary S. Stein, Brune Trevant, Barry S. Komm, Peter V.N. Bodine, Sadiq Hussain, John Symons, Jane B. Lian, Tripti Gaur
Publikováno v:
Journal of Cellular Physiology. 217:113-126
The Wnt signaling pathway is involved in the regulation of embryonic development, induction of cell polarity, self renewal of hematopoietic stem cells, determination of cell fate and apoptosis (Eaves, 2003; Reya et al., 2003; Willert et al., 2003; Nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec96db60e1913a68b8da0f01059f2b32
https://doi.org/10.1002/jcp.21482
https://doi.org/10.1002/jcp.21482
Publikováno v:
Journal of Cellular Biochemistry. 105:497-502
Wnts are secreted glycoproteins that control vital biological processes, including embryogenesis, organogenesis and tumorigenesis. Wnts are classified into several subfamilies depending on the signaling pathways they activate, with the canonical subf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1630197ee3937f5c5b1a7e6f84eaef61
https://doi.org/10.1002/jcb.21848
https://doi.org/10.1002/jcb.21848
Publikováno v:
Endocrinology. 149:6084-6091
The menopausal transition is associated with decreased ovarian function and concomitant decline in estrogen production, which may result in physiological effects such as hot flashes, reduced bone mass, and altered lipid profile. It is well establishe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dc797631a3cf66863b7f02ac7a21cb3
https://doi.org/10.1210/en.2008-0817
https://doi.org/10.1210/en.2008-0817
Publikováno v:
Molecular Endocrinology. 21:3050-3061
Ror2 receptor plays a key role in bone formation, but its signaling pathway is not completely understood. We demonstrate that Ror2 homodimerizes at the cell surface, and that dimerization can be induced by a bivalent antibody. Antibody-mediated dimer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cf972ecb9ed66293949b783fd7004a5
https://doi.org/10.1210/me.2007-0323
https://doi.org/10.1210/me.2007-0323