Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Peter V. Dubovskii"'
Autor:
Peter V. Dubovskii, Yuri N. Utkin
Publikováno v:
Toxins, Vol 16, Iss 6, p 262 (2024)
Cytotoxins (CTs) are three-finger membrane-active toxins present mainly in cobra venom. Our analysis of the available CT amino acid sequences, literature data on their membrane activity, and conformational equilibria in aqueous solution and detergent
Externí odkaz:
https://doaj.org/article/62a207b921f24a71a16ff71d1fad7d15
Autor:
Peter V. Dubovskii, Anastasia A. Ignatova, Anna S. Alekseeva, Vladislav G. Starkov, Ivan A. Boldyrev, Alexey V. Feofanov, Yuri N. Utkin
Publikováno v:
Toxins, Vol 15, Iss 1, p 6 (2022)
In aqueous solutions, cobra cytotoxins (CTX), three-finger folded proteins, exhibit conformational equilibrium between conformers with either cis or trans peptide bonds in the N-terminal loop (loop-I). The equilibrium is shifted to the cis form in to
Externí odkaz:
https://doaj.org/article/e5bc9fea67aa413bbaee97dbd23a3a0f
Autor:
Peter V. Dubovskii, Kira M. Dubova, Gleb Bourenkov, Vladislav G. Starkov, Anastasia G. Konshina, Roman G. Efremov, Yuri N. Utkin, Valeriya R. Samygina
Publikováno v:
Toxins, Vol 14, Iss 2, p 149 (2022)
Cobra cytotoxins (CTs) belong to the three-fingered protein family and possess membrane activity. Here, we studied cytotoxin 13 from Naja naja cobra venom (CT13Nn). For the first time, a spatial model of CT13Nn with both “water” and “membrane
Externí odkaz:
https://doaj.org/article/0070f421d8124d2aaff9386ae360706a
Publikováno v:
Biochemical and biophysical research communications. 558
Cobra cytotoxins (CTs), the three-fingered proteins, feature high amino acid sequence homology in the beta-strands and variations in the loop regions. We selected a pair of cytotoxins from Naja kaouthia crude venom to clarify the sequence-structure r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f385643c8514063acb556fe52ce7140e
https://pubmed.ncbi.nlm.nih.gov/34620492
https://pubmed.ncbi.nlm.nih.gov/34620492
Publikováno v:
Journal of chemical information and modeling. 61(1)
For many peripheral membrane-binding polypeptides(MBPs), especially β-structural ones, the precise molecular mechanisms of membrane insertion remain unclear. In most cases, only the terminal water-soluble and membrane-bound states have been elucidat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41081c5012ed6e7be7e9f7d9a8c27d77
https://pubmed.ncbi.nlm.nih.gov/33382618
https://pubmed.ncbi.nlm.nih.gov/33382618
Publikováno v:
Biochemical and Biophysical Research Communications. 579:188
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::409403b1704ba4b7e038e45fe7ccb9cd
https://doi.org/10.1016/j.bbrc.2021.09.077
https://doi.org/10.1016/j.bbrc.2021.09.077
Autor:
Alexey V. Feofanov, Anastasia A. Ignatova, Yuri N. Utkin, Roman G. Efremov, Peter V. Dubovskii
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:126890
Antibacterial activity of the three-finger toxins from cobra venom, including cytotoxin 3 from N. kaouthia, cardiotoxin-like basic polypeptide A5 from N. naja (CLBP), and alpha-neurotoxin from N. oxiana venom, was investigated. All toxins failed to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614e9ae495129e016b2fe7188d424b0e
https://doi.org/10.1016/j.bmcl.2019.126890
https://doi.org/10.1016/j.bmcl.2019.126890
Autor:
Peter V. Dubovskii, Igor Ivanov, Anastasia A. Ignatova, Pavel E. Volynsky, Alexey V. Feofanov, Maxim N. Zhmak, Roman G. Efremov
Publikováno v:
Future medicinal chemistry. 10(19)
Aim: Spider venom is a rich source of antibacterial peptides, whose hemolytic activity is often excessive. Methodology: How to get rid of it? Using latarcins from Lachesana tarabaevi and oxyopinin Oxt 4a from Oxyopes takobius spider venoms we perform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f00c3dd4f5452e3ba98528daf1294a2
https://pubmed.ncbi.nlm.nih.gov/30215282
https://pubmed.ncbi.nlm.nih.gov/30215282
Autor:
Peter V. Dubovskii, Yuri N. Utkin
Publikováno v:
Current Topics in Medicinal Chemistry. 15:638-648
Cytotoxins (or cardiotoxins, CTs) are small rigid membrane-active proteins of the three-finger toxin (TFT) family. They comprise about 60 amino acid residues, stabilized by four disulphide bridges. CTs, the most abundant proteins in cobra venom are a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::794926b4f4e0debdc409fc7b1d842335
https://doi.org/10.2174/1568026615666150217113011
https://doi.org/10.2174/1568026615666150217113011
Autor:
Yulia Pustovalova, Pavel E. Volynsky, Roman G. Efremov, Maxim A. Dubinnyi, Yuri N. Utkin, Peter V. Dubovskii, Alexander S. Arseniev, Anastasia G. Konshina
Publikováno v:
Journal of biomolecular structuredynamics. 36(13)
Cobra cytotoxins (CTs) belong to the three-fingered protein family. They are classified into S- and P-types, the latter exhibiting higher membrane-perturbing capacity. In this work, we investigated the interaction of CTs with phospholipid bilayers, u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e621a77cc07187b546f2e13818006daa
https://pubmed.ncbi.nlm.nih.gov/28990854
https://pubmed.ncbi.nlm.nih.gov/28990854