Zobrazeno 1 - 10
of 446
pro vyhledávání: '"Peter V Coveney"'
Publikováno v:
Communications Physics, Vol 7, Iss 1, Pp 1-8 (2024)
Abstract Data-driven approaches offer novel opportunities for improving the performance of turbulent flow simulations, which are critical to wide-ranging applications from wind farms and aerodynamic designs to weather and climate forecasting. However
Externí odkaz:
https://doaj.org/article/b1b56ded9290410fa56a665bc17a5805
Autor:
Claudio A Franco, Martin L Jones, Miguel O Bernabeu, Anne-Clemence Vion, Pedro Barbacena, Jieqing Fan, Thomas Mathivet, Catarina G Fonseca, Anan Ragab, Terry P Yamaguchi, Peter V Coveney, Richard A Lang, Holger Gerhardt
Publikováno v:
eLife, Vol 5 (2016)
Endothelial cells respond to molecular and physical forces in development and vascular homeostasis. Deregulation of endothelial responses to flow-induced shear is believed to contribute to many aspects of cardiovascular diseases including atheroscler
Externí odkaz:
https://doaj.org/article/e92ade92ceda483ab96de81991bbabb1
Autor:
Jon W. S. McCullough, Peter V. Coveney
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract Uncertainty quantification is becoming a key tool to ensure that numerical models can be sufficiently trusted to be used in domains such as medical device design. Demonstration of how input parameters impact the quantities of interest genera
Externí odkaz:
https://doaj.org/article/08de63607c9c4777b859e348b18ab7e8
Publikováno v:
npj Computational Materials, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract Uncertainty quantification (UQ) is rapidly becoming a sine qua non for all forms of computational science out of which actionable outcomes are anticipated. Much of the microscopic world of atoms and molecules has remained immune to these dev
Externí odkaz:
https://doaj.org/article/3744256a73054b3698c83341beb1ccbe
Autor:
Claudio A Franco, Martin L Jones, Miguel O Bernabeu, Ilse Geudens, Thomas Mathivet, Andre Rosa, Felicia M Lopes, Aida P Lima, Anan Ragab, Russell T Collins, Li-Kun Phng, Peter V Coveney, Holger Gerhardt
Publikováno v:
PLoS Biology, Vol 13, Iss 5, p e1002163 (2015)
[This corrects the article DOI: 10.1371/journal.pbio.1002125.].
Externí odkaz:
https://doaj.org/article/8e2b316e4e87403b8eabbbaa558f2835
Autor:
Claudio A Franco, Martin L Jones, Miguel O Bernabeu, Ilse Geudens, Thomas Mathivet, Andre Rosa, Felicia M Lopes, Aida P Lima, Anan Ragab, Russell T Collins, Li-Kun Phng, Peter V Coveney, Holger Gerhardt
Publikováno v:
PLoS Biology, Vol 13, Iss 4, p e1002125 (2015)
Patterning of functional blood vessel networks is achieved by pruning of superfluous connections. The cellular and molecular principles of vessel regression are poorly understood. Here we show that regression is mediated by dynamic and polarized migr
Externí odkaz:
https://doaj.org/article/663453f3238d45cbb13917b0d72e3ea5
Autor:
David W Wright, Ilona P Deuzing, Philippe Flandre, Peter van den Eede, Micheline Govaert, Laurentia Setiawan, Peter V Coveney, Anne-Geneviève Marcelin, Vincent Calvez, Charles A B Boucher, Nancy Beerens
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e74078 (2013)
Reverse transcriptase (RT) plays an essential role in HIV-1 replication, and inhibition of this enzyme is a key component of HIV-treatment. However, the use of RT inhibitors can lead to the emergence of drug-resistant variants. Until recently, most c
Externí odkaz:
https://doaj.org/article/86a74e3780bc431f88da87b542faedce
Autor:
Balázs Könnyű, S Kashif Sadiq, Tamás Turányi, Rita Hírmondó, Barbara Müller, Hans-Georg Kräusslich, Peter V Coveney, Viktor Müller
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 6, p e1003103 (2013)
Proteolytic processing of Gag and Gag-Pol polyproteins by the viral protease (PR) is crucial for the production of infectious HIV-1, and inhibitors of the viral PR are an integral part of current antiretroviral therapy. The process has several layers
Externí odkaz:
https://doaj.org/article/82ac4668fad6452f9ba6b8cf8c9f086f
Autor:
Jon W. S. McCullough, Peter V. Coveney
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract On a global scale, cerebro- and cardiovascular diseases have long been one of the leading causes of death and disability and their prevalence appears to be increasing in recent times. Understanding potential biomarkers and risk factors will
Externí odkaz:
https://doaj.org/article/98554da4b976414d883caf08ca0011cb
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Non-periodic solutions are an essential property of chaotic dynamical systems. Simulations with deterministic finite-precision numbers, however, always yield orbits that are eventually periodic. With 64-bit double-precision floating-point nu
Externí odkaz:
https://doaj.org/article/25dec25a8ddf48428e478d206873abe7