Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Peter V, Lidsky"'
Autor:
Ranen Aviner, Peter V Lidsky, Yinghong Xiao, Michel Tassetto, Damian Kim, Lichao Zhang, Patrick L McAlpine, Joshua Elias, Judith Frydman, Raul Andino
Publikováno v:
PLoS Pathogens, Vol 20, Iss 2, p e1011535 (2024)
A better mechanistic understanding of virus-host dependencies can help reveal vulnerabilities and identify opportunities for therapeutic intervention. Of particular interest are essential interactions that enable production of viral proteins, as thos
Externí odkaz:
https://doaj.org/article/4f949c539917425396f505f21d021d7c
Autor:
Xiaoquan Li, Peter V Lidsky, Yinghong Xiao, Chien-Ting Wu, Miguel Garcia-Knight, Junjiao Yang, Tsuguhisa Nakayama, Jayakar V Nayak, Peter K Jackson, Raul Andino, Xiaokun Shu
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009898 (2021)
The respiratory disease COVID-19 is caused by the coronavirus SARS-CoV-2. Here we report the discovery of ethacridine as a potent drug against SARS-CoV-2 (EC50 ~ 0.08 μM). Ethacridine was identified via high-throughput screening of an FDA-approved d
Externí odkaz:
https://doaj.org/article/552d796afa0a42e6b7dcd1f4fccebbef
Autor:
Junjiao Yang, Yinghong Xiao, Peter V. Lidsky, Chien-Ting Wu, Luke R. Bonser, Shiming Peng, Miguel A. Garcia-Knight, Michel Tassetto, Chan-I Chung, Xiaoquan Li, Tsuguhisa Nakayama, Ivan T. Lee, Jayakar V. Nayak, Khadija Ghias, Kirsten L. Hargett, Brian K. Shoichet, David J. Erle, Peter K. Jackson, Raul Andino, Xiaokun Shu
Publikováno v:
Nat Microbiol
Nature microbiology, vol 8, iss 1
Nature microbiology, vol 8, iss 1
The coronavirus SARS-CoV-2 causes the severe disease COVID-19. SARS-CoV-2 infection is initiated by interaction of the viral spike protein and host receptor angiotensin-converting enzyme 2 (ACE2). We report an improved bright and reversible fluorogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::798e39d277c2392b2cac949a17527082
https://doi.org/10.1038/s41564-022-01288-5
https://doi.org/10.1038/s41564-022-01288-5
Autor:
Peter V. Lidsky, Raul Andino
Publikováno v:
Trends in Ecology & Evolution. 37:1046-1057
Aging is often attributed to the detrimental side effects of beneficial traits but not a programmed adaptive process. Alternatively, the pathogen control hypothesis posits that defense against infectious diseases may provide a strong selection force
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eab02bc369523d9f49de84e83bd0405
https://doi.org/10.1016/j.tree.2022.08.003
https://doi.org/10.1016/j.tree.2022.08.003
Publikováno v:
Trends in Ecology & Evolution.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d495182d4994a17fb7f51a4a82c5c53
https://doi.org/10.1016/j.tree.2023.05.004
https://doi.org/10.1016/j.tree.2023.05.004
Publikováno v:
Biochemistry. Biokhimiia, vol 87, iss 12
Aging is an evolutionary paradox. Several hypotheses have been proposed to explain it, but none fully explains all the biochemical and ecologic data accumulated over decades of research. We suggest that senescence is a primitive immune strategy which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52fe729a10ad3edacd74b9f757dd8460
https://escholarship.org/uc/item/1q1226qn
https://escholarship.org/uc/item/1q1226qn
Drosophilais a classic experimental system used in fundamental and biopharmaceutical research. Manipulating gene expression in the larvae and adult flies can facilitate basic and translational studies. Here we report a method for robust transgene ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fefe054cbaff4fb53882c10d2d541e0
https://doi.org/10.1101/2022.10.30.514414
https://doi.org/10.1101/2022.10.30.514414
Autor:
Leah C, Dorman, Phi T, Nguyen, Caroline C, Escoubas, Ilia D, Vainchtein, Yinghong, Xiao, Peter V, Lidsky, Haruna, Nakajo, Nicholas J, Silva, Christian, Lagares-Linares, Ellen Y, Wang, Sunrae E, Taloma, Beatriz, Cuevas, Hiromi, Nakao-Inoue, Brianna M, Rivera, Bjoern, Schwer, Carlo, Condello, Raul, Andino, Tomasz J, Nowakowski, Anna V, Molofsky
Publikováno v:
bioRxiv : the preprint server for biology.
Microglia, the innate immune cells of the brain, are exquisitely sensitive to dynamic changes in the neural environment. Using single cell RNA sequencing of the postnatal somatosensory cortex during topographic remapping, we identified a type I inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::77fff49b25e7b36499cbc1dc125ab87a
https://pubmed.ncbi.nlm.nih.gov/35233577
https://pubmed.ncbi.nlm.nih.gov/35233577
Autor:
Chien-Ting Wu, Peter V. Lidsky, Yinghong Xiao, Ran Cheng, Ivan T. Lee, Tsuguhisa Nakayama, Sizun Jiang, Wei He, Janos Demeter, Miguel G. Knight, Rachel E. Turn, Laura S. Rojas-Hernandez, Garry Nolan, Carlos Milla, Jayakar V. Nayak, Raul Andino, Peter K. Jackson
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c567297448cf9d4242c65da9a9070a05
https://doi.org/10.2139/ssrn.4089984
https://doi.org/10.2139/ssrn.4089984
Autor:
Chien-Ting Wu, Peter V. Lidsky, Yinghong Xiao, Ran Cheng, Ivan T. Lee, Tsuguhisa Nakayama, Sizun Jiang, Wei He, Janos Demeter, Miguel G. Knight, Rachel E. Turn, Laura S. Rojas-Hernandez, Chengjin Ye, Kevin Chiem, Judy Shon, Luis Martinez-Sobrido, Carolyn R. Bertozzi, Garry P. Nolan, Jayakar V. Nayak, Carlos Milla, Raul Andino, Peter K. Jackson
Publikováno v:
Cell. 186:112-130.e20
How SARS-CoV-2 penetrates the airway barrier of mucus and periciliary mucins to infect nasal epithelium remains unclear. Using primary nasal epithelial organoid cultures, we found that the virus attaches to motile cilia via the ACE2 receptor. SARS-Co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5b121f0f2c61f1e100123a7ef99118d
https://doi.org/10.1016/j.cell.2022.11.030
https://doi.org/10.1016/j.cell.2022.11.030