Asthma in Primary Care: Making Guidelines Work

Autor: Wayne Putnam, Fred Burge, Sue Tatemichi, Peter Twohig

Publikováno v: Canadian Respiratory Journal, Vol 8, Iss Suppl A, Pp 29A-34A (2001)

OBJECTIVE: To determine the views of family physicians regarding selected asthma recommendations from a Canadian practice guideline and the supporting evidence, and to identify issues needing further development if family physicians are to find guide

Externí odkaz: https://doaj.org/article/fefeec5049054321b6db70c66e1c8664

Activation of naïve CD4+ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4+ T cells

Autor: Simon Arnett Jones, Jasmine Li, Florian Wiede, Michael J. Townsend, Gareth W. Jones, Xiao Liu, Costantino Pitzalis, Robert Andrews, Jason Peter Twohig, Alicia Derrac Soria, Philip R. Taylor, Javier Uceda Fernandez, Tony Tiganis, Barbara Szomolay, David Hill, Myles Lewis, Chris Pepper, Benjamin C. Cossins, Nigel Williams, Ana Cardus Figueras, David Millrine

Publikováno v: Twohig, J, Figueras, A C, Andrews, R, Wiede, F, Cossins, B, Soria, A D, Lewis, M, Townsend, M, Millrine, D, Hill, D, Fernandez, J U, Liu, X, Szomolay, B, Pepper, C, Taylor, P, Pitzalis, C, Tiganis, T, Williams, N, Jones, G, Jones, S & Li, J 2019, ' Activation of naïve CD4 + T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4 + T cells ', Nature Immunology, vol. 20, no. 4, pp. 458-470 . https://doi.org/10.1038/s41590-019-0350-0

The cytokine IL-6 controls the survival, proliferation and effector characteristics of lymphocytes through activation of the transcription factors STAT1 and STAT3. While STAT3 activity is an ever-present feature of IL-6 signaling in CD4 + T cells, pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08f2d84d1e02e30b242a82730c030eed
https://doi.org/10.1038/s41590-019-0350-0

Regulation of Early Cartilage Destruction in Inflammatory Arthritis by Death Receptor 3

Autor: Fraser L. Collins, Edward Chung Yern Wang, Zarabeth Newton, William Victor Perks, Anwen Sian Williams, Stephen Clark, Jason Peter Twohig, Olivia Hayward, Ravinder K. Singh

Publikováno v: Arthritis & Rheumatology. 66:2762-2772

Objective: To investigate the role of death receptor 3 (DR-3) and its ligand tumor necrosis factor–like molecule 1A (TL1A) in the early stages of inflammatory arthritis. Methods: Antigen-induced arthritis (AIA) was generated in C57BL/6 mice deficie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ccc95a0d4855ebf291a97ca240fd7f9
https://doi.org/10.1002/art.38770

Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation

Autor: Gareth W. Jones, Simon Arnett Jones, Nicholas Topley, Thomas L. Foster, Christopher A. Hunter, Edward Chung Yern Wang, Paul J. Hertzog, Brendan J. Jenkins, Jason Peter Twohig, Anwen Sian Williams, Jason S. Stumhofer

Publikováno v: University of Bristol-PURE

Tumor necrosis factor (TNF)-like cytokine (TL1A) is a T-cell costimulator that bolsters cytokine-induced activation through death receptor 3 (DR3). To explore the relationship between T-cell activation and TL1A responsiveness, flow cytometry profiled

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5fcb3a3d8318687ee9a675971cd7e26
https://doi.org/10.1096/fj.10-166843

Defective B cell ontogeny and immune response in human complement receptor 2 (CR2, CD21) transgenic mice is partially recovered in the absence of C3

Autor: Jason Peter Twohig, Kevin J. Marchbank, Andreas Rossbach, Liudmila Kulik, Catherine Haluszczak, V.M. Holers, J Reuter, M Bull

Publikováno v: Molecular Immunology. 44:3434-3444

Mice prematurely expressing human CR2 (hCR2) in the B cell lineage have a defective B cell ontogeny and immune response. Our recent analysis of this phenotype suggested that signaling through hCR2 and presumably mouse CD19 on the B cell surface, duri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a104d087360433d943a357cf35e5432f
https://doi.org/10.1016/j.molimm.2007.02.011