Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Peter Topley"'
Publikováno v:
Vaccine. 22:1799-1809
Imiquimod, an immune response modifier and inducer of cytokines in vitro and in vivo, has been shown to have potent antiviral and antitumour activity and to act as an adjuvant for protein vaccination. We have undertaken studies in mice to investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::037aa534477eafed3c7f9aff299f0b97
https://doi.org/10.1016/j.vaccine.2003.09.052
https://doi.org/10.1016/j.vaccine.2003.09.052
Autor:
Kate L White, Sarah Marina Walcott, Michael A. Romanos, Andrew R. Lloyd, Elmer B. Santos, Gerald Wayne Gough, Philip K. Nicholls, Vanita Parmar, Lindy L. Thomsen, Davina M. Anderson, Richard A. Moore, Margaret Stanley, Peter Topley
Publikováno v:
Virology. 304(2):451-459
DNA plasmids encoding the open reading frames of canine oral papillomavirus (COPV) nonstructural early genes E1, E2, or E7 protein were delivered into both oral mucosal and cutaneous epithelial sites in beagle dogs using particle-mediated immunothera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c2d98a56723e45c5260f08b8d58983
Autor:
Fiona Campbell, Sylvain Baulande, Peter Topley, Marije van Zanten, Jonathan Henry Ellis, Herve Jean-Clement Lab. Glaxo Wellcome Coste, Sandra Vivinus, Philippe Dessen
Publikováno v:
European Journal of Biochemistry. 268:1908-1917
The untranslated regions of mRNAs encoding heat-shock proteins have been reported to contain elements important to the post-transcriptional regulation of these key components of the stress response. In this report we describe an element from the 5'UT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70f12f18a48f36393b1791c4eec625ad
https://doi.org/10.1046/j.1432-1327.2001.02064.x
https://doi.org/10.1046/j.1432-1327.2001.02064.x
Autor:
Benjamin M. Chain, Cathy A. van Wely, Tite John Philip, Remi J. Creusot, Lindy L. Thomsen, Peter Topley
Publikováno v:
Vaccine. 19:1678-1687
The early responses of CD4+ T cells to particle-mediated DNA immunisation were investigated using OVA-specific TCR-transgenic CD4+ T cells. Following adoptive transfer of these cells, mice were immunised by delivery into the skin of a plasmid encodin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81f750f1928da03c1fb339e754e0c128
https://doi.org/10.1016/s0264-410x(00)00405-9
https://doi.org/10.1016/s0264-410x(00)00405-9
Publikováno v:
Fusion Protein Technologies for Biopharmaceuticals: Applications and Challenges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e57b7089417a4eaf7f4dbaffba8cc76
https://doi.org/10.1002/9781118354599.ch11
https://doi.org/10.1002/9781118354599.ch11
Autor:
Jeremy N. Stables, Robert Shaw, Peter Topley, Irene M. Leigh, Connie J. Sexton, A. T. Williams, Carol Lovegrove
Publikováno v:
Journal of General Virology. 76:3107-3112
Human papillomaviruses (HPVs) are important human pathogens associated with a range of epithelial neoplasia. The rising incidence of HPV infection and association of HPV with malignancy has led to increased interest in appropriate management of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634474d32ede114a42f59e4095cdfcee
https://doi.org/10.1099/0022-1317-76-12-3107
https://doi.org/10.1099/0022-1317-76-12-3107
Autor:
Marilyn Jansen, Gary K. Smith, David S. Duch, Jacqueline I. Lee, Michael J. Dykstra, Jeremy Stables, Peter Topley, Robert J. Mullin, Vincent C. Knick
Publikováno v:
Biochemical Pharmacology. 47:1067-1078
Clinical responses for anticancer agents are based upon tumor regression. We have investigated the potential of glycineamide ribonucleotide transformylase (GAR TFase) inhibitors to produce regressions in multiple preclinical models of colon carcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16620ff373751c7981dc7a5b0c845f8b
https://doi.org/10.1016/0006-2952(94)90419-7
https://doi.org/10.1016/0006-2952(94)90419-7
Autor:
Fiona C. Cook, Grainne Dunlevy, Peter Topley, Adam Walker, Marie Davies, Daniel Rycroft, Tom Herbert, Steve Holmes, Lucy J. Holt, Chris Herring, Laurent Jespers
Publikováno v:
Protein engineering, designselection : PEDS. 23(4)
Serum albumin-binding domain antibodies (AlbudAbs) have previously been shown to greatly extend the serum half-life of the interleukin-1 receptor antagonist IL-1ra. We have subsequently extended this approach to look at the in vitro activity, in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e1f889c87b923ba9e6092016a09acc4
https://pubmed.ncbi.nlm.nih.gov/20093262
https://pubmed.ncbi.nlm.nih.gov/20093262
Autor:
Margaret Stanley, Andrew R. Lloyd, Davina M. Anderson, Lindy L. Thomsen, Sarah Marina Walcott, Peter Topley, Suchitra Jain, Richard A. Moore, Gerald Wayne Gough, Kate L White
Publikováno v:
Virology. 314(2)
Following challenge with COPV (canine oral papillomavirus), DNA plasmids encoding COPV L1, E1 or E2 protein were delivered into oral mucosal and cutaneous sites in beagles using particle-mediated immunotherapeutic delivery (PMID). Two weeks post-chal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e2a6b0064dcb117ef846be698a71924
https://pubmed.ncbi.nlm.nih.gov/14554090
https://pubmed.ncbi.nlm.nih.gov/14554090
Autor:
David Spalding, Stuart Cockerill, Malcolm Clive Carter, Peter Topley, Lindy L. Thomsen, D. J. Hayes, Patrick M. Woollard, Jeremy N. Stables, Karen Affleck, Malcolm Willson, Colin Stubberfield, Robert D. Shaw, Amanda Jowett, Steve McKeown, Kathryn Jane Smith, Stephen Barry Guntrip
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(11)
Described herein is the design and synthesis of indazolylaminopyridopyrimidines and quinazolines as inhibitors of the class 1 tyrosine kinase receptor family. Data is presented for N(4)-(1-benzyl-1H-indazol-5-yl)-N(6),N(6)-dimethylpyrido[3,4-d]pyrimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c48edb70e191bcbba4e0e927907dd7f9
https://pubmed.ncbi.nlm.nih.gov/11378364
https://pubmed.ncbi.nlm.nih.gov/11378364