Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Peter Tobin"'
Autor:
Peter D. McClelland, Peter Tobin
Using recent polling results, this book identifies the core economic components of the American Dream: standard of living, financial security, and upward mobility. The authors document the trend in each of these components over the last thirty years,
Autor:
Phil Flentje, Connor Larkin, Damian Mulcahy, Larissa Hettiarachchi, Dan Horan, James Cox, Stuart Milling, Peter Tobin, Kevin Bogie
Publikováno v:
Australian Geomechanics Journal. 57:115-134
Eastern Australia has experienced a significant magnitude rainfall event of extended duration in the first 7 months of 2022. Across the east coast of New South Wales (NSW) a series of troughs and East Coast Lows occurred during a La Nina weather cycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8e917437fda3c800fc65c69f897f862
https://doi.org/10.56295/agj5736
https://doi.org/10.56295/agj5736
Publikováno v:
Bearing Capacity of Roads, Railways and Airfields ISBN: 9781315100333
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8c7122202a455d86933c89ff8c10113
https://doi.org/10.1201/9781315100333-136
https://doi.org/10.1201/9781315100333-136
Publikováno v:
Cancer Chemotherapy and Pharmacology. 57:309-316
Purpose: Recently, it was shown that chrysin causes upregulation of UGT1A1 in Caco-2 intestinal cells. Therefore, we proposed that oral chrysin may reduce irinotecan (CPT-11) induced diarrhoea by shifting the SN-38G/SN-38 equilibrium towards the inac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::864ddc00272f4746a01edad754cd90d9
https://doi.org/10.1007/s00280-005-0053-0
https://doi.org/10.1007/s00280-005-0053-0
Autor:
Peter Tobin, Laurent P. Rivory
Publikováno v:
Drug Design Reviews - Online. 1:341-346
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0298ba1ca28b42622b33b8403c1382f7
https://doi.org/10.2174/1567269043390573
https://doi.org/10.2174/1567269043390573
Autor:
Peter Tobin, Michael Crawford, Tony Eyers, Michael J. Solomon, Stephen Clarke, Laurent P. Rivory, James J. Gallagher, Soon C. Lee, Sally Aulds, J. Paul Seale
Publikováno v:
British journal of clinical pharmacology. 62(1)
Irinotecan (CPT-11) is a prodrug that is used to treat metastatic colorectal cancer. It is activated to the topoisomerase poison SN-38 by carboxylesterases. SN-38 is metabolized to its inactive glucuronide, SN-38 glucuronide. The aim of this study wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f82f3132313249383da8b918b47ad83
https://pubmed.ncbi.nlm.nih.gov/16842384
https://pubmed.ncbi.nlm.nih.gov/16842384
Publikováno v:
The Journal of pharmacy and pharmacology. 57(1)
Patients treated with irinotecan (CPT-11) occasionally suffer from severe diarrhoea and aggressive treatment with loperamide at the first signs of loose stools is recommended. We have examined the effect of loperamide on the hepatic metabolism and bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b89ede29d7d38ce15f3ee74c3c09683e
https://pubmed.ncbi.nlm.nih.gov/15638991
https://pubmed.ncbi.nlm.nih.gov/15638991
Publikováno v:
Oncology Reports.
Irinotecan (CPT-11) is a prodrug that is used to treat metastatic colorectal cancer. It is activated to the topoisomerase poison SN-38 by carboxylesterases. SN-38 is subsequently metabolised to its inactive glucuronide, SN-38G, which can however be r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5ed362ad5d4943cfaa9cd80b1aa5f77
https://doi.org/10.3892/or.10.6.1977
https://doi.org/10.3892/or.10.6.1977
Autor:
Peter Tobin, Peter J. Houghton, Pam J. Cheshire, Laurent P. Rivory, Clinton F. Stewart, Suzan K. Hanna, Helen M. Dodds
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 303(2)
The anticancer drug irinotecan (CPT-11) is activated to the potent topoisomerase I inhibitor, SN-38 (7-ethyl-10-hydroxycamptothecin), by esterases. SN-38 is in turn conjugated to the inactive SN-38 glucuronide (SN-38G). The reverse reaction is mediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7948b84f0015b22bf9a3ac86332fd278
https://pubmed.ncbi.nlm.nih.gov/12388647
https://pubmed.ncbi.nlm.nih.gov/12388647
Autor:
S. Fields, S. Lee, Stephen Clarke, P. Seale, Laurent P. Rivory, Michael J. Solomon, Peter Tobin
Publikováno v:
Journal of Clinical Oncology. 23:3650-3650
3650 Background: Irinotecan (CPT-11) is a prodrug that is used in the management of metastatic colorectal cancer. It is activated by carboxylesterases to produce the cytotoxic metabolite SN-38. SN-...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f71ab4da51b665fc011a51a4cdf9fde
https://doi.org/10.1200/jco.2005.23.16_suppl.3650
https://doi.org/10.1200/jco.2005.23.16_suppl.3650