Spatiotemporal dissection of the cell cycle with single-cell proteogenomics

Autor: Diana Mahdessian, Fredrik Pontén, Mathias Uhlén, Manuel D. Leonetti, Fredric Johansson, Anna Bäckström, Christian Gnann, Frida Danielsson, Emma Lundberg, Lovisa Stenström, Peter Thul, Adil Mardinoglu, Nathan H. Cho, Cheng Zhang, Rutger Shutten, Devin P. Sullivan, Charlotte Stadler, Oana Carja, Trang Le, Ulrika Axelsson, Cecilia Lindskog, Anthony J. Cesnik, Muhammad Arif, Burcu Ayoglu

Publikováno v: Nature. 590:649-654

The cell cycle, over which cells grow and divide, is a fundamental process of life. Its dysregulation has devastating consequences, including cancer1-3. The cell cycle is driven by precise regulation of proteins in time and space, which creates varia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93712525b3c2ce056e389066343dbcbc
https://doi.org/10.1038/s41586-021-03232-9

Spatial Characterization of the Human Centrosome Proteome Opens Up New Horizons for a Small but Versatile Organelle

Autor: Frida Danielsson, Emma Lundberg, Devin P. Sullivan, Diana Mahdessian, Mathias Uhlén, Peter Thul, Jens S. Andersen, Ulrika Axelsson

Publikováno v: Danielsson, F, Mahdessian, D, Axelsson, U, Sullivan, D, Uhlén, M, Andersen, J S, Thul, P J & Lundberg, E 2020, ' Spatial Characterization of the Human Centrosome Proteome Opens up New Horizons for a Small but Versatile Organelle ', Proteomics, vol. 20, no. 23, 1900361 . https://doi.org/10.1002/pmic.201900361

After a century of research, the human centrosome continues to fascinate. Based on immunofluorescence and confocal microscopy, an extensive inventory of the protein components of the human centrosome, and the centriolar satellites, with the important

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a396ecc519f716529d9041237e0345
https://pubmed.ncbi.nlm.nih.gov/32558245

The human secretome

Autor: Linnéa Strandberg, Jan Mulder, Linn Fagerberg, Wen Zhong, Evelina Sjöstedt, Andreas Hober, Bjørn G. Voldborg, Abdellah Tebani, Peter Thul, Björn Forsström, Devin P. Sullivan, Göran Bergström, David Kotol, Fredrik Pontén, Sara Kanje, Anders Gummesson, Borbala Katona, Sophia Hober, Åsa Sivertsson, Jochen M. Schwenk, Anna Berling, Emil Lindström, Jimmy Vuu, Anne-Sophie Svensson, Jens Nielsen, Burcu Ayoglu, Emma Lundberg, Magdalena Malm, Cecilia Lindskog, Per Oksvold, Tea Dodig-Crnković, Charlotte Stadler, Ragna S. Häussler, Julia Scheffel, Melanie Dannemeyer, Hanna Tegel, Anna-Luisa Volk, Max J. Karlsson, Adil Mardinoglu, Martin Zwahlen, Magnus Lundqvist, Siri Ekblad, Peter Nilsson, Mathias Uhlén, Kalle von Feilitzen, Frida Danielsson, Anna Månberg, Jonathan L. Robinson, Diana Mahdessian, Elisa Pin, Fredrik Edfors, Johan Rockberg, Mun-Gwan Hong

Publikováno v: Science signaling. 12(609)

The proteins secreted by human cells (collectively referred to as the secretome) are important not only for the basic understanding of human biology but also for the identification of potential targets for future diagnostics and therapies. Here, we p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f229d2aa95b4d40ca2b172cd8066af
https://pubmed.ncbi.nlm.nih.gov/31772123

A subcellular map of the human proteome

Autor: Anna Bäckström, Fredrik Pontén, Jan Mulder, Lisa M. Breckels, Peter Thul, Anna Asplund, Evelina Sjöstedt, Lars Björk, Diana Mahdessian, Casper F. Winsnes, Jenny Fall, Hanna Tegel, Devin P. Sullivan, Rutger Schutten, Fredric Johansson, Mathias Uhlén, Charlotte Stadler, Linn Fagerberg, Kathryn S. Lilley, Martin Hjelmare, Johan Rockberg, Emma Lundberg, Laurent Gatto, Cecilia Lindskog, Christian Gnann, Marie Skogs, Åsa Sivertsson, Aikaterini Geladaki, Martin Zwahlen, Tove Alm, Sophia Hober, Claire M. Mulvey, Adil Mardinoglu, Sunjae Lee, Kalle von Feilitzen, Frida Danielsson, Cheng Zhang, Lovisa Åkesson, Per Oksvold, Mikaela Wiking, Peter Nilsson, Hammou Ait Blal, Jochen M. Schwenk

Publikováno v: Science (New York, N.Y.). 356(6340)

Mapping the proteome Proteins function in the context of their environment, so an understanding of cellular processes requires a knowledge of protein localization. Thul et al. used immunofluorescence microscopy to map 12,003 human proteins at a singl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fa6bdd71fbfe2f2e49a68f818b9c962
https://pubmed.ncbi.nlm.nih.gov/28546174

BEYOND RALLY FEMALE-ONLY JUNIOR WRC PRIZE DRIVE SHARED FOR NOW.

Publikováno v: Motorsport News; 10/24/2024, p10-10, 1/5p, 1 Color Photograph