Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Peter Ten Holte"'
Autor:
Guido Verniest, Norbert De Kimpe, Jan-Willem Thuring, Matthias Moens, Frederik Deroose, Peter ten Holte, Matthias De Schrijver
Publikováno v:
Tetrahedron. 68:9284-9288
A strategy toward the synthesis of functionalized 5,5-difluoropiperidines, a class of compounds with potential as building block in medicinal chemistry, was developed. In a three-step procedure 2,2-difluoroglutaric anhydride was synthesized starting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6670008556c3524cac7275004736fd7d
https://doi.org/10.1016/j.tet.2012.08.049
https://doi.org/10.1016/j.tet.2012.08.049
Autor:
Frederik Deroose, Karel Piron, Riccardo Surmont, Peter ten Holte, Sara Kenis, Norbert De Kimpe, Guido Verniest, Jan Willem Thuring
Publikováno v:
Tetrahedron. 68:6941-6947
A synthetic route toward new 8,8-difluoro-1,6-naphthyridine-5,7-diones, which are of interest as new building blocks in pharmaceutical chemistry, is described. The key steps include a copper-mediated cross-coupling of ethyl bromodifluoroacetate and 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d803ba749790b60b745eb89a36481f3
https://doi.org/10.1016/j.tet.2012.05.122
https://doi.org/10.1016/j.tet.2012.05.122
Autor:
Michael D. Hack, Andrew Skalkin, Peter Ten Holte, Dimitris K. Agrafiotis, Mark Seierstad, Christophe Buyck, Dmitrii N. Rassokhin, Taraneh Mirzadegan, Todd K. Jones
Publikováno v:
Journal of Chemical Information and Modeling. 51:3275-3286
We present a novel approach for enhancing the diversity of a chemical library rooted on the theory of the wisdom of crowds. Our approach was motivated by a desire to tap into the collective experience of our global medicinal chemistry community and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::579aceb1661c32a26939f2875c9a9be5
https://doi.org/10.1021/ci200446y
https://doi.org/10.1021/ci200446y
Autor:
Peter Ten Holte
Publikováno v:
Small Molecule Medicinal Chemistry: Strategies and Technologies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e3299c345de5d186f9845bcb36742f5
https://doi.org/10.1002/9781118771723.ch3
https://doi.org/10.1002/9781118771723.ch3
Autor:
Peter ten Holte, Boudewijn Janssens, Sandrine Gaurrand, Janine Arts, Jacky van Gompel, Virginie Sophie Poncelet, Patrick Angibaud, Ann Marien, Hans De Winter, Bruno Roux, An Aerts, Verdonck Marc Gustaaf Celine, Jacky Van Dun, Luc Van Hijfte, Kristof Van Emelen, Isabelle Noëlle Constance Pilatte, Eddy Jean Edgard Freyne, Wim Floren, Michel Janicot, Sven Franciscus Anna Van Brandt, Jean-Michel Argoullon, Laurence Queguiner
Publikováno v:
European Journal of Medicinal Chemistry. 40:597-606
A series of pyrimidyl-5-hydroxamic acids was prepared for evaluation as inhibitors of histone deacetylase (HDAC). Amino-2-pyrimidinyl can be used as a linker to provide HDAC inhibitors of good enzymatic potency.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abdbd08dce8f647012c95f1517777f59
https://doi.org/10.1016/j.ejmech.2005.01.008
https://doi.org/10.1016/j.ejmech.2005.01.008
Publikováno v:
Organic Letters. 4:497-500
[reaction: see text] Enantiomerically pure N-tosyl-2,3-aziridine alcohols are directly converted into 4-hydroxy-4,5-dihydroisoxazole 2-oxides through oxidation to the corresponding aldehydes followed by in situ tandem nitroaldol-intramolecular cycliz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f04f1c0e3ce8e990083dad2a3d4a935a
https://doi.org/10.1021/ol0170152
https://doi.org/10.1021/ol0170152
Publikováno v:
Tetrahedron Letters. 39:7407-7410
Polymer-supported sulfonyl chloride is used in the solid-phase synthesis of disubstituted 1,3-oxazolidin-2ones. The target compounds were prepared by attaching 1,2-diols to the solid support, followed by reaction with p-toluenesulfonyl isocyanate and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bd8670279e8daafa5f34b1dc2ef0bb0
https://doi.org/10.1016/s0040-4039(98)01608-6
https://doi.org/10.1016/s0040-4039(98)01608-6
Autor:
Matthias De Schrijver, Guido Verniest, Peter ten Holte, Frederik Deroose, Matthias Moens, Norbert De Kimpe, Jan-Willem Thuring
Publikováno v:
ChemInform. 44
Title compounds, e.g (V), are prepared as potential building blocks in medicinal chemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75c7ec69682772476803fdac275d483d
https://doi.org/10.1002/chin.201312129
https://doi.org/10.1002/chin.201312129
Autor:
Karel Piron, Riccardo Surmont, Norbert De Kimpe, Guido Verniest, Sara Kenis, Peter ten Holte, Frederik Deroose, Jan Willem Thuring
Publikováno v:
ChemInform. 44
A copper-mediated cross-coupling of difluoroacetate (II) with haloarenes followed by hydrolysis of the nitrile group/cyclization gives access to title compounds.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93d8b0a0f0ce32ca09c566ac75637428
https://doi.org/10.1002/chin.201301140
https://doi.org/10.1002/chin.201301140
Autor:
Guido Verniest, Riccardo Surmont, Peter ten Holte, Jan Willem Thuring, Norbert De Kimpe, Frederik Deroose, Mathias De Schrijver
Publikováno v:
ChemInform. 42
Fluorinated pyrazoles bearing additional functional groups that allow further functionalization are of considerable interest as building blocks in medicinal chemistry. The developed synthetic strategy for new 3-amino-4-fluoropyrazoles consists of a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17302669c5186e0a233c5b4a8277006e
https://doi.org/10.1002/chin.201136119
https://doi.org/10.1002/chin.201136119