Zobrazeno 1 - 10
of 554
pro vyhledávání: '"Peter Ten Dijke"'
Autor:
Anouk van der Net, Zaid Rahman, Ankur D. Bordoloi, Iain Muntz, Peter ten Dijke, Pouyan E. Boukany, Gijsje H. Koenderink
Publikováno v:
iScience, Vol 27, Iss 12, Pp 111424- (2024)
Summary: Epithelial-to-mesenchymal transitions (EMT) and unjamming transitions provide two distinct pathways for cancer cells to become invasive, but it is still unclear to what extent these pathways are connected. Here, we addressed this question by
Externí odkaz:
https://doaj.org/article/484aae2e6b1d490a82a5331aa6ff987d
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-18 (2023)
Abstract Metastasis is the leading cause of cancer-related deaths. Transforming growth factor beta (TGF-β) signaling drives metastasis and is strongly enhanced during cancer progression. Yet, the use of on-target TGF-β signaling inhibitors in the t
Externí odkaz:
https://doaj.org/article/9bb0f02efb034e0c9c89d7c9a48e9cec
Autor:
Yang Hao, Sen Ma, Zili Gu, Alireza Haghparast, Timo Schomann, Zhenfeng Yu, Yuanyuan He, Xiaoxv Dong, Luis J Cruz, Peter ten Dijke
Publikováno v:
Cancer Communications, Vol 43, Iss 4, Pp 513-518 (2023)
Externí odkaz:
https://doaj.org/article/e4d22267e14c4c74a9cf19bb458b1e6c
Autor:
Lonneke Rotteveel, Alex J. Poot, Esther J. M. Kooijman, Robert C. Schuit, Ingrid Schalij, Xiaoqing Sun, Kondababu Kurakula, Chris Happé, Wissam Beaino, Peter ten Dijke, Adriaan A. Lammertsma, Harm Jan Bogaard, Albert D. Windhorst
Publikováno v:
EJNMMI Research, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Transforming growth factor β (TGFβ) activity is perturbed in remodelled pulmonary vasculature of patients with pulmonary arterial hypertension (PAH), cancer, vascular diseases and developmental disorders. Inhibition of TGFβ, which signals
Externí odkaz:
https://doaj.org/article/d4e5834623554ec79cfeb8672ef8eb29
Publikováno v:
MedComm, Vol 4, Iss 4, Pp n/a-n/a (2023)
Abstract Immune checkpoint inhibitors (ICIs) have shown remarkable success in cancer treatment. However, in cancer patients without sufficient antitumor immunity, numerous data indicate that blocking the negative signals elicited by immune checkpoint
Externí odkaz:
https://doaj.org/article/b2492f23f9e647fd80df24463a55f385
Autor:
Feng Xie, Xiaoxue Zhou, Peng Su, Heyu Li, Yifei Tu, Jinjin Du, Chen Pan, Xiang Wei, Min Zheng, Ke Jin, Liyan Miao, Chao Wang, Xuli Meng, Hans van Dam, Peter ten Dijke, Long Zhang, Fangfang Zhou
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Understanding the factors that hamper immune therapy in breast cancer may increase the range of patients who benefit. Here authors show that breast cancer cells produce and subsequently transfer active TGF-β type II receptors to CD8 + T cells to ren
Externí odkaz:
https://doaj.org/article/38ffd7d9ac664b15a78b87301f59ec04
Autor:
Yang Hao, Chih Kit Chung, Zili Gu, Timo Schomann, Xiaoxu Dong, Ruben V. Huis in ‘t Veld, Marcel G. M. Camps, Peter ten Dijke, Ferry A. Ossendorp, Luis J. Cruz
Publikováno v:
Molecular Biomedicine, Vol 3, Iss 1, Pp 1-20 (2022)
Abstract Photodynamic therapy (PDT) has shown impressive therapeutic effects on various types of cancers by reactive oxygen species (ROS) generation and induction of immune responses. However, under certain conditions, the immune responses induced by
Externí odkaz:
https://doaj.org/article/47f779d9e6be49d58d382c744779d7fe
Autor:
Yutaro Tsubakihara, Yae Ohata, Yukari Okita, Shady Younis, Jens Eriksson, Mikael E. Sellin, Jiang Ren, Peter ten Dijke, Kohei Miyazono, Atsuhiko Hikita, Takeshi Imamura, Mitsuyasu Kato, Carl‐Henrik Heldin, Aristidis Moustakas
Publikováno v:
Molecular Oncology, Vol 16, Iss 12, Pp 2330-2354 (2022)
Transforming growth factor β (TGFβ) induces epithelial–mesenchymal transition (EMT), which correlates with stemness and invasiveness. Mesenchymal–epithelial transition (MET) is induced by TGFβ withdrawal and correlates with metastatic coloniza
Externí odkaz:
https://doaj.org/article/efbbbf26dd9f4806acc431c346def40f
Autor:
Jingxu Guo, Bin Liu, Midory Thorikay, Minmin Yu, Xiaoyan Li, Zhen Tong, Richard M. Salmon, Randy J. Read, Peter ten Dijke, Nicholas W. Morrell, Wei Li
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Mutations in BMPR2 is the major genetic cause for pulmonary arterial hypertension (PAH). Here by solving crystal structures of BMPRII in binary and ternary receptor complexes with BMP10, the authors report the molecular recognition between BMPRII and
Externí odkaz:
https://doaj.org/article/3560786f93824f9e82ae50b7dd42ce97
Autor:
Chuannan Fan, Qian Wang, Gerard van der Zon, Jiang Ren, Cedrick Agaser, Roderick C. Slieker, Prasanna Vasudevan Iyengar, Hailiang Mei, Peter ten Dijke
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-18 (2022)
Abstract Ovo-like transcriptional repressor 1 (OVOL1) is a key mediator of epithelial lineage determination and mesenchymal–epithelial transition (MET). The cytokines transforming growth factor-β (TGF-β) and bone morphogenetic proteins (BMP) cont
Externí odkaz:
https://doaj.org/article/208e70df02064c99b2afac086ccd608d