Výsledky vyhledávání - "Peter T.M. Kenny"

The synthesis, structural characterization and biological evaluation of novel N-{para-(ferrocenyl) ethynyl benzoyl} amino acid and dipeptide methyl and ethyl esters as anticancer agents

Autor: Andy G. Harry, James P. Murphy, Dilip K. Rai, John Crown, Peter T.M. Kenny, Norma O'Donovan

Publikováno v: Journal of Organometallic Chemistry. 846:379-388

A series of N -{ para -(ferrocenyl) ethynyl benzoyl} amino acid and dipeptide methyl and ethyl esters 4–18 were prepared by coupling para -(ferrocenyl) ethynyl benzoic acid 3 to the amino acids GABA(OMe), GABA(OEt) and the dipeptide esters GlyGly(O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d8ad9e41bdd915fc72b0d709932139e
https://doi.org/10.1016/j.jorganchem.2017.07.019

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Investigations of vibrational spectra and bioactivity of novel anticancer drug N -(6-ferrocenyl-2-naphthoyl)-gamma-amino butyric acid ethyl ester

Autor: S. R. Rajina, Peter T.M. Kenny, S. G. Praveen, Geethu Sudhi, T.S. Xavier, D. Jaiswal-Nagar, J. Binoy

Publikováno v: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 185:234-244

The bioactivity of compounds is mainly dependent on molecular structure and the present work aims to explore the bonding features responsible for biological activity of novel anticancer drug N -(6-ferrocenyl-2-naphthoyl)-gamma-amino butyric acid ethy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1083192b292c1542d569f12496c629
https://doi.org/10.1016/j.saa.2017.05.056

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The electron transport mechanism in ester and its influence on bioactivity in the anticancer drug N-(6-ferrocenyl-2-naphthoyl)-L-alanine-glycine ethyl ester(FNLAGEE)

Autor: J. Binoy, T.S. Xavier, S. R. Rajina, Peter T.M. Kenny, S. G. Praveen, Geethu Sudhi

Publikováno v: AIP Conference Proceedings.

The reactivity of ester group plays key role in inducing bioactivity of many ferrocenyl biconjugated compounds. The ester reactivity can be explained, based on electron transport mechanism using vibrational spectroscopy, aided by DFT simulation. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e87a12fe28fd55ae1d25c1339866f824
https://doi.org/10.1063/1.5032829

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Multispectroscopic investigation of the interaction of BSA and DNA with the anticancer drug, N-(6-ferrocenyl-2-naphthoyl)-gamma-amino butyric acid methyl ester

Autor: S. R. Rajina, P. Austin, S. G. Praveen, J. Binoy, Peter T.M. Kenny, Geethu Sudhi, T.S. Xavier

Publikováno v: AIP Conference Proceedings.

The interaction of a drug with DNA and BSA play a great role in studying anti cancer activity and drug transport properties, which can be effectively, investigated using vibrational spectroscopy, UV visible spectroscopy and Fluorescence spectroscopy.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::258d8cb44b846bb8730ab480aebd94d4
https://doi.org/10.1063/1.5032833

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FT-IR and Raman spectroscopic and DFT studies of anti-cancer active molecule N-{(meta-ferrocenyl) Benzoyl} – l -Alanine – Glycine ethyl ester

Autor: Peter T.M. Kenny, T.S. Xavier, D. Manimaran, I. Hubert Joe

Publikováno v: Europe PubMed Central

FT-Raman and FT-IR spectra of N-{(meta-ferrocenyl) Benzoyl} - l-alanine - glycine ethyl ester were recorded in solid phase. The optimized molecular geometry, the vibrational wavenumbers, the infrared intensities and the Raman scattering intensities w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7a1028ac8baafa5127ee1e3006207d
https://doi.org/10.1016/j.saa.2015.02.087

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The synthesis, structural characterization and in vitro anticancer activity of novel 1-alkyl-1′-N-meta-(ferrocenyl) benzoyl dipeptide esters and novel 1-alkyl-1′-N-ortho-(ferrocenyl) benzoyl dipeptide esters

Autor: John Crown, Mary T. Pryce, Jennifer C. Manton, Peter T.M. Kenny, William E. Butler, Andy G. Harry, Dilip K. Rai, Norma O'Donovan

Publikováno v: Journal of Organometallic Chemistry. 766:1-12

1-Alkyl-1′- N - meta -(ferrocenyl) benzoyl dipeptide esters 7–18 and 1-alkyl-1′- N - ortho -(ferrocenyl) benzoyl dipeptide esters 19–30 were prepared by coupling the alkyl ferrocenyl benzoic acids 1–6 to the dipeptide ethyl esters Gly-Gly(O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac37a75ca5e84c3aa36e7c7df8042539
https://doi.org/10.1016/j.jorganchem.2014.04.027

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The synthesis, structural characterization and in vitro anti-cancer activity of novel 1-alkyl-1′-N-para-(ferrocenyl) benzoyl dipeptide esters

Autor: John Crown, William E. Butler, Mary T. Pryce, Dilip K. Rai, Peter T.M. Kenny, Andy G. Harry, Jennifer C. Manton, Norma O'Donovan

Publikováno v: Journal of Organometallic Chemistry. 757:28-35

1-Alkyl-1′- N - para -(ferrocenyl) benzoyl dipeptide esters 4 – 12 were prepared by coupling the alkyl ferrocenyl benzoic acids 1 – 3 to the dipeptide ethyl esters Gly- L -Ala(OEt), Gly- L -Leu(OEt) and Gly- L -Phe(OEt) using the standard N -(3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::21d049a7d21d01fb7f8e4f7a69ed7cb7
https://doi.org/10.1016/j.jorganchem.2014.01.031

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The synthesis, structural characterization and in vitro anti-cancer activity of novel N-{6-(ferrocenyl) ethynyl-2-naphthoyl} amino acid and dipeptide ethyl esters

Autor: Andy G. Harry, Norma O'Donovan, James T. Murphy, Peter T.M. Kenny, Dilip K. Rai, Rachel Tiedt, Áine Mooney, William E. Butler, Mary T. Pryce, Jennifer C. Manton, John Crown, Naomi Walsh

Publikováno v: Journal of Organometallic Chemistry. 734:86-92

N -{6-(Ferrocenyl) ethynyl-2-naphthoyl} amino acid and dipeptide ethyl esters 2 – 8 were prepared by coupling 6-(ferrocenyl) ethynyl-2-naphthoic acid 1 to the amino acid ethyl ester GABA(OEt) and the dipeptide ethyl esters GlyGly(OEt), GlyAla(OEt),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e1de298b037b1eb5bc1b0ae6b275d1e3
https://doi.org/10.1016/j.jorganchem.2012.11.041

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