Animal‐free applications in the development of cell‐based therapies

Autor: Peter van Meer, Jan Willem van der Laan, Carla Herberts, Tineke van den Hoorn, Peter T. Theunissen

Publikováno v: British Journal of Clinical Pharmacology. 87:2425-2427

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1efa0ba8ea7c5175ee491a98a5957f9
https://doi.org/10.1111/bcp.14544

Analysis of exposure margins in developmental toxicity studies for detection of human teratogens

Autor: Joseph J. DeGeorge, Paul A. Andrews, José A. Lebrón, Maia L. Green, Diann Blanset, Britta A. Mattson, Luana de Castro Oliveira, Daniel Minck, Peter T. Theunissen, Rajkumar Kadaba, Abigail Jacobs, Martin D. Green, Priscila Lemos Costa, Mary Ellen McNerney

Publikováno v: Regulatory toxicology and pharmacology : RTP. 105

The draft Step 2 ICH S5(R3) guideline includes an exposure-based endpoint as an option for selecting the high-dose in reproductive and developmental toxicity studies. To help determine an appropriate exposure margin for embryofetal developmental toxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3209fa2b180399a4985b5451dc84fc
https://pubmed.ncbi.nlm.nih.gov/30981719

Complementary Detection of Embryotoxic Properties of Substances in the Neural and Cardiac Embryonic Stem Cell Tests

Autor: Jos C. S. Kleinjans, Jeroen L. A. Pennings, Joshua F. Robinson, Dorien A.M. van Dartel, Peter T. Theunissen, Aldert H. Piersma

Publikováno v: Toxicological Sciences, 132(1), 118-130. Oxford University Press
Toxicological sciences 132 (2013) 1
Toxicological sciences, 132(1), 118-130

In developmental toxicity testing, in vitro screening assays are highly needed to increase efficiency and to reduce animal use. A promising in vitro assay is the cardiac embryonic stem cell test (ESTc), in which the effect of developmental toxicants

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53cefc580a3eabd664e58a96b5fb808d
https://doi.org/10.1093/toxsci/kfs333

Transcriptomic Concentration-Response Evaluation of Valproic Acid, Cyproconazole, and Hexaconazole in the Neural Embryonic Stem Cell Test (ESTn)

Autor: Aldert H. Piersma, Peter T. Theunissen, Jeroen L. A. Pennings, Jos C. S. Kleinjans, Esther de Jong, Joshua F. Robinson, Sandra M.H. Claessen

Publikováno v: Toxicological Sciences, 125(2), 430. Oxford University Press
Toxicological Sciences, 125(2), 430-438. Oxford University Press

Alternative developmental toxicity assays are urgently needed to reduce animal use in regulatory developmental toxicology. We previously designed an in vitro murine neural embryonic stem cell test (ESTn) as a model for neurodevelopmental toxicity tes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a747a73bf7b75bdb3d963ae4652cd3da
https://doi.org/10.1093/toxsci/kfr293

An abbreviated protocol for multilineage neural differentiation of murine embryonic stem cells and its perturbation by methyl mercury

Autor: Sjors H.W. Schulpen, Sanne A.B. Hermsen, Peter T. Theunissen, F.J. van Schooten, Aldert H. Piersma, D.A.M. van Dartel

Publikováno v: Reproductive Toxicology, 29(4), 383-392. Elsevier Inc.
Reproductive Toxicology, 29(4), 383. Elsevier

Alternative assays are highly desirable to reduce the extensive experimental animal use in developmental toxicity testing. In the present study, we developed an improved test system for assessing neurodevelopmental toxicity using differentiating embr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f98111b0613f4966f82b854355b6e4c6
https://doi.org/10.1016/j.reprotox.2010.04.003