Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Peter T. Jones"'
Autor:
Gregory Paul Winter, E. Sally Ward, Peter T. Jones, Tim Buss, Richard C. Willson, Cristina Rada
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
In a scientific career that spanned over three decades, Dr. Jeff Foote made seminal contributions to antibody humanization and the biophysical aspects of antibody recognition. In this Perspective, we discuss his life and work.
Publikováno v:
Journal of Microelectromechanical Systems. 25:432-439
The occurrence of adhesion-induced failures at microelectromechanical systems (MEMSs), also referred to as stiction, can be triggered by a variety of environmental, geometrical, and operational parameters, such as compressive contact forces acting in
Autor:
Peter T. Jones
Publikováno v:
Journal of Industrial Ecology. 13:843-846
Autor:
W. Gregory Shriver, James P. Gibbs, Peter D. Vickery, H. Lisle Gibbs, Thomas P. Hodgman, Peter T. Jones, Christopher N. Jacques
Publikováno v:
The Auk. 122:94-107
Hybridization is pivotal in framing ideas about species concepts and has the potential to produce novel genotypes that may serve as starting points for new evolutionary trajectories. Presently, Nelson’s Sharp-tailed Sparrows (Ammodramus nelsoni sub
Publikováno v:
Journal of Molecular Biology. 268:69-77
Sequence diversity in the human antibody repertoire is generated in two steps: by the combinatorial assembly of V gene segments and by somatic hypermutation. Here, we have characterised these processes for the lambda (lambda) light chain using a libr
Autor:
Jane K. Osbourn, John C. Earnshaw, Anne W Field, Peter T. Jones, Elaine Joy Derbyshire, John McCaffertya, Deborah Allen, Jane Wilton
Publikováno v:
Immunotechnology. 2:181-196
Background : A human single chain Fv (scFv) specific for human carcinoembryonic antigen (CEA) has been isolated from a 2.0 × 10 9 phage display library from unimmunised human donors. The dissociation constant of the scFv has been measured by surface
Autor:
Ian M. Tomlinson, Peter T. Jones, Paul H. Dear, Erik L. L. Sonnhammer, Gerald Walter, Greg Winter
Publikováno v:
Journal of Molecular Biology. 256:813-817
In the human immune system, antibodies with high affinities for antigen are created in two stages. A diverse primary repertoire of antibody structures is produced by the combinatorial rearrangement of germline V gene segments and antibodies are selec
Publikováno v:
Molecular Immunology. 29:213-220
The serum half-lives of a wild-type recombinant mouse monoclonal antibody of the IgG2b isotype and a mutant antibody differing from the wild-type antibody by a single amino acid substitution introduced into the CH2 domain, the replacement of Asn 297
Autor:
Peter T. Jones, Alan J. Cumber, Sylvia Denham, Edward J. Wawrzynczak, Greg Winter, Geoffrey D. Parnell
Publikováno v:
Molecular Immunology. 29:221-227
The serum half-lives of three recombinant mouse monoclonal antibodies, differing radically in their ability to bind to C1q or FcRI but only minimally in structure, were determined in the BALB/c mouse following intravenous administration. The wild-typ
Autor:
Royston Jefferis, Greg Winte, Barry A. Levine, Tracy Bentley, John Lund, Margaret Goodall, Peter T. Jones, John D. Pound, Alexander R. Duncan
Publikováno v:
Molecular Immunology. 29:53-59
Important mammalian defensive functions such as phagocytosis are triggered in leukocytes by the interaction of the Fc region of IgG with cell surface receptors (Fc gamma R). The CH2 domain of IgG has been implicated previously as the site of interact