Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Peter T. Meinke"'
Autor:
Melanie Balbach, Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Carla Ritagliati, Robert W. Myers, David J. Huggins, Clemens Steegborn, Ileana C. Miranda, Peter T. Meinke, Jochen Buck, Lonny R. Levin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Half of all pregnancies are unintended; thus, existing family planning options are inadequate. This proof-of-concept study validates an on-demand contraception strategy for men, showing high effectiveness in quickly and temporarily reducing male fert
Externí odkaz:
https://doaj.org/article/95c1debb563241228352ba4e29c74a64
Autor:
Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Hannes Buck, Clemens Steegborn, Robert W. Myers, Peter T. Meinke, Lonny R. Levin, Jochen Buck
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/4e985b67c0f441afacd084154e3cbd87
Autor:
Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Hannes Buck, Clemens Steegborn, Robert W. Myers, Peter T. Meinke, Lonny R. Levin, Jochen Buck
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
In mammalian cells, 10 different adenylyl cyclases produce the ubiquitous second messenger, cyclic adenosine monophosphate (cAMP). Amongst these cAMP-generating enzymes, bicarbonate (HCO3−)-regulated soluble adenylyl cyclase (sAC; ADCY10) is unique
Externí odkaz:
https://doaj.org/article/79059c54d75b4a94ab021be7ad8ea4df
Autor:
Shan Sun, Makoto Fushimi, Thomas Rossetti, Navpreet Kaur, Jacob Ferreira, Michael Miller, Jonathan Quast, Joop van den Heuvel, Clemens Steegborn, Lonny R. Levin, Jochen Buck, Robert W. Myers, Stacia Kargman, Nigel Liverton, Peter T. Meinke, David J. Huggins
Publikováno v:
Journal of Chemical Information and Modeling. 63:2828-2841
Autor:
Hao Zhang, John Ginn, Wenhu Zhan, Annie Leung, Yi J. Liu, Akinori Toita, Rei Okamoto, Tzu-Tshin Wong, Toshihiro Imaeda, Ryoma Hara, Mayako Michino, Takafumi Yukawa, Sevil Chelebieva, Patrick K. Tumwebaze, Jeremie Vendome, Thijs Beuming, Kenjiro Sato, Kazuyoshi Aso, Philip J. Rosenthal, Roland A. Cooper, Nigel Liverton, Michael Foley, Peter T. Meinke, Carl F. Nathan, Laura A. Kirkman, Gang Lin
Publikováno v:
Journal of Medicinal Chemistry. 66:1484-1508
Autor:
Michael Miller, Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Melanie Balbach, Navpreet Kaur, Lonny R. Levin, Jochen Buck, Maria Kehr, Sandrine Coquille, Joop van den Heuvel, Clemens Steegborn, Makoto Fushimi, Efrat Finkin-Groner, Robert W. Myers, Stacia Kargman, Nigel J. Liverton, David J. Huggins, Peter T. Meinke
Publikováno v:
J Med Chem
Soluble adenylyl cyclase (sAC: ADCY10) is an enzyme involved in intracellular signaling. Inhibition of sAC has potential therapeutic utility in a number of areas. For example, sAC is integral to successful male fertility: sAC activation is required f
Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia
Autor:
Yiman Liu, Qinglan Li, Fatemeh Alikarami, Declan R. Barrett, Leila Mahdavi, Hangpeng Li, Sylvia Tang, Tanweer A. Khan, Mayako Michino, Connor Hill, Lele Song, Lu Yang, Yuanyuan Li, Sheela Pangeni Pokharel, Andrew W. Stamford, Nigel Liverton, Louis M. Renzetti, Simon Taylor, Gillian F. Watt, Tammy Ladduwahetty, Stacia Kargman, Peter T. Meinke, Michael A. Foley, Junwei Shi, Haitao Li, Martin Carroll, Chun-Wei Chen, Alessandro Gardini, Ivan Maillard, David J. Huggins, Kathrin M. Bernt, Liling Wan
Publikováno v:
Cancer Discovery. 12:2684-2709
The chromatin reader eleven–nineteen leukemia (ENL) has been identified as a critical dependency in acute myeloid leukemia (AML), but its therapeutic potential remains unclear. We describe a potent and orally bioavailable small-molecule inhibitor o
Autor:
Liling Wan, Kathrin M. Bernt, David J. Huggins, Ivan Maillard, Alessandro Gardini, Chun-Wei Chen, Martin Carroll, Haitao Li, Junwei Shi, Michael A. Foley, Peter T. Meinke, Stacia Kargman, Tammy Ladduwahetty, Gillian F. Watt, Simon Taylor, Louis M. Renzetti, Nigel Liverton, Andrew W. Stamford, Sheela Pangeni Pokharel, Yuanyuan Li, Lu Yang, Lele Song, Connor Hill, Mayako Michino, Tanweer A. Khan, Sylvia Tang, Hangpeng Li, Leila Mahdavi, Declan R. Barrett, Fatemeh Alikarami, Qinglan Li, Yiman Liu
Supplementary Data from Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0e032c6cb527a071007d7e437dfd6e
https://doi.org/10.1158/2159-8290.22541677.v1
https://doi.org/10.1158/2159-8290.22541677.v1
Autor:
Liling Wan, Kathrin M. Bernt, David J. Huggins, Ivan Maillard, Alessandro Gardini, Chun-Wei Chen, Martin Carroll, Haitao Li, Junwei Shi, Michael A. Foley, Peter T. Meinke, Stacia Kargman, Tammy Ladduwahetty, Gillian F. Watt, Simon Taylor, Louis M. Renzetti, Nigel Liverton, Andrew W. Stamford, Sheela Pangeni Pokharel, Yuanyuan Li, Lu Yang, Lele Song, Connor Hill, Mayako Michino, Tanweer A. Khan, Sylvia Tang, Hangpeng Li, Leila Mahdavi, Declan R. Barrett, Fatemeh Alikarami, Qinglan Li, Yiman Liu
The chromatin reader eleven–nineteen leukemia (ENL) has been identified as a critical dependency in acute myeloid leukemia (AML), but its therapeutic potential remains unclear. We describe a potent and orally bioavailable small-molecule inhibitor o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dda37f869094a53ad62552e6a254079
https://doi.org/10.1158/2159-8290.c.6549718
https://doi.org/10.1158/2159-8290.c.6549718
Autor:
Hao Zhang, John Ginn, Wenhu Zhan, Yi J. Liu, Annie Leung, Akinori Toita, Rei Okamoto, Tzu-Tshin Wong, Toshihiro Imaeda, Ryoma Hara, Takafumi Yukawa, Mayako Michino, Jeremie Vendome, Thijs Beuming, Kenjiro Sato, Kazuyoshi Aso, Peter T. Meinke, Carl F. Nathan, Laura A. Kirkman, Gang Lin
Publikováno v:
Journal of Medicinal Chemistry. 65:9350-9375
With over 200 million cases and close to half a million deaths each year, malaria is a threat to global health, particularly in developing countries.