A systematic review of transcriptomic studies of the human endometrium reveals inconsistently reported differentially expressed genes

Autor: Evangeline R Walker, Mollie McGrane, John D Aplin, Daniel R Brison, Peter T Ruane

Publikováno v: Reproduction and Fertility, Vol 4, Iss 3, Pp 1-13 (2023)

Genome-wide analysis of gene expression has been widely applied to study the endometrium, although to our knowledge no systematic reviews have been performed. Here, we identified 74 studies that described transcriptomes from whole (unprocessed) endom

Externí odkaz: https://doaj.org/article/21b461f7e77b49ca8a9ea3bbafac4ab2

Characterisation of Osteopontin in an In Vitro Model of Embryo Implantation

Autor: Stéphane C Berneau, Peter T Ruane, Daniel R Brison, Susan J Kimber, Melissa Westwood, John D Aplin

Publikováno v: Cells, Vol 8, Iss 5, p 432 (2019)

At the onset of pregnancy, embryo implantation is initiated by interactions between the endometrial epithelium and the outer trophectoderm cells of the blastocyst. Osteopontin (OPN) is expressed in the endometrium and is implicated in attachment and

Externí odkaz: https://doaj.org/article/089f6d7b97634a63b4785fc7e9939468

Trophectoderm differentiation to invasive syncytiotrophoblast is promoted by endometrial epithelial cells during human embryo implantation

Autor: Peter T Ruane, Terence Garner, Lydia Parsons, Phoebe A Babbington, Ivan Wangsaputra, Susan J Kimber, Adam Stevens, Melissa Westwood, Daniel R Brison, John D Aplin

Publikováno v: Ruane, P T, Garner, T, Parsons, L, Babbington, P A, Wangsaputra, I, Kimber, S J, Stevens, A, Westwood, M, Brison, D R & Aplin, J D 2022, ' Trophectoderm differentiation to invasive syncytiotrophoblast is promoted by endometrial epithelial cells during human embryo implantation ', Human Reproduction, vol. 37, no. 4, pp. 777-792 . https://doi.org/10.1093/humrep/deac008

STUDY QUESTION How does the human embryo breach the endometrial epithelium at implantation? SUMMARY ANSWER Embryo attachment to the endometrial epithelium promotes the formation of multinuclear syncytiotrophoblast from trophectoderm, which goes on to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28fff5d90749ee4396840910255bf3e0
https://doi.org/10.1093/humrep/deac008

Investigating the role of CD44 and hyaluronate in embryo-epithelial interaction using an in vitro model

Autor: Daniel R Brison, Peter T Ruane, Stéphane Berneau, Susan J. Kimber, John D. Aplin, Melissa Westwood

Publikováno v: Berneau, S, Ruane, P, Brison, D R, Kimber, S, Westwood, M & Aplin, J 2019, ' Investigating the role of CD44 and hyaluronate in embryo-epithelial interaction using an in-vitro model ', Molecular Human Reproduction . https://doi.org/10.1093/molehr/gaz011

Implantation failure is an important impediment to increasing success rates in assisted reproductive technologies. Knowledge of the cascade of morphological and molecular events at implantation remains limited. Cell surface CD44 and hyaluronate (HA)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa9832b739151367a82b634d25e483a
https://doi.org/10.1093/molehr/gaz011

Clinical efficacy of hyaluronate-containing embryo transfer medium in IVF/ICSI treatment cycles: a cohort study

Autor: Stephen A Roberts, Tope Adeniyi, Daniel R. Brison, Gregory Horne, Peter T Ruane

Publikováno v: Human Reproduction Open
Adeniyi, T, Horne, G, Ruane, P T, Brison, D R & Roberts, S A 2021, ' Clinical efficacy of hyaluronate-containing embryo transfer medium in IVF/ICSI treatment cycles: a cohort study ', Human Reproduction Open, vol. 2021, no. 1, hoab004 . https://doi.org/10.1093/hropen/hoab004

STUDY QUESTION Does the duration of embryo exposure to hyaluronic acid (HA) enriched medium improve the rate of live birth events (LBEs)? SUMMARY ANSWER The use of embryo transfer (ET) medium rich in HA improves LBE (a singleton or twin live birth) r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea48306158ce60927ab0a78eba95f728
https://pubmed.ncbi.nlm.nih.gov/33718621