Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Peter T Rowley"'
Publikováno v:
Genetic Testing. 9:313-319
What is the impact of a genetic evaluation for colorectal cancer susceptibility? We previously reported a study of individuals diagnosed with colorectal cancer at 60 years of age or less in a five-county area of New York including Rochester. Subjects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::962a867373019e87e4054f22d9681415
https://doi.org/10.1089/gte.2005.9.313
https://doi.org/10.1089/gte.2005.9.313
Publikováno v:
Genetic Testing. 9:255-260
Newborn screening for cystic fibrosis (CF) is expanding because early diagnosis has been shown to result in improved nutrition and growth. Most newborns identified by a mutation panel have a single detected mutation and require sweat testing to exclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e1da52cef4c17d6cf301825ce937b6
https://doi.org/10.1089/gte.2005.9.255
https://doi.org/10.1089/gte.2005.9.255
Publikováno v:
Genetic Testing. 8:1-12
Previously, we have reported a clinical trial in which any woman in a defined geographic region who had a qualifying family history and who was referred by her physician or who was identified through a regional cancer registry was offered free geneti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e3ee82443ccf23c6012e24e20cb4cfb
https://doi.org/10.1089/109065704323015987
https://doi.org/10.1089/109065704323015987
Publikováno v:
Genetic Testing. 6:281-290
Are patients identified from a cancer registry better educated directly or via their physician about screening for an inherited susceptibility for colorectal cancer? Of 974 patients diagnosed with ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0946775d3d7bed346e339ee5e75cff8d
https://doi.org/10.1089/10906570260471813
https://doi.org/10.1089/10906570260471813
Autor:
Peter T Rowley
Publikováno v:
Expert Opinion on Therapeutic Patents. 11:1815-1823
Telomerase is an RNA-dependent DNA polymerase that synthesises chromosomal DNA ends called telomeres. Telomerase is present in most malignant cells but absent in most normal cells. It is arguably the most distinctive component common to immortal cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9315b7946497f3f2a7701bdd857ae620
https://doi.org/10.1517/13543776.11.12.1815
https://doi.org/10.1517/13543776.11.12.1815
Autor:
Barbara A. Kosciolek, Peter T. Rowley
Publikováno v:
Leukemia Research. 23:1097-1103
Since telomerase activity is present in most malignant cells, but absent in most normal cells, its induction in normal cells warrants scrutiny. Therefore we have analyzed the inducibility of telomere-related components in normal lymphocytes during th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e66da47d024229c6068d6795b952fc6c
https://doi.org/10.1016/s0145-2126(99)00134-4
https://doi.org/10.1016/s0145-2126(99)00134-4
Publikováno v:
Molecular Medicine. 5:693-700
Antisense represents a conceptually powerful method for regulating gene expression. However, antisense oligonucleotides developed to date manifest two serious limitations—nuclease susceptibility and nonspecific hybridization. Circular oligonucleoti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::343a8627626e470fb7b35efb5fd053c5
https://doi.org/10.1007/bf03401988
https://doi.org/10.1007/bf03401988
Autor:
Alan E. Donnenfeld, Hilary Harris, Stacey C Fitzsimmons, Margaret McGovern, Peter T Rowley, Jeryl L. Erickson, M. Priscilla Short, Lewis B. Holmes, Linda A. Bradley, Randall Keichi Saiki, Michael F. Greene, Barbara A. Bernhardt, Katherine W. Klinger, Nachama L Wilker, Michael Katz, Richard A. Doherty, John Tabone, Reed E. Pyeritz, Paula K. Haddow, Glenn E. Palomaki, Richard M. Ferrie, Michael L. LeFevre, Brian Cheuvront, Stephen Little, George C. Cunningham, David R. Witt, R. Rodney Howell, James E. Haddow, Greg L. Loeben, Henry A. Erlich, Wayne W. Grody, Nicholas Wald, Edward M. Kloza, David J. H. Brock
Publikováno v:
Genetics in Medicine. 1:129-135
Purpose: To summarize a conference convened to examine how cystic fibrosis screening might appropriately be introduced into routine prenatal practice. Methods: Participants included experts from various relevant disciplines. Systematic reviews and da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a485e18bb83c651cfbe57459c1447e
https://doi.org/10.1097/00125817-199905000-00003
https://doi.org/10.1097/00125817-199905000-00003
Autor:
Barbara A. Kosciolek, Peter T. Rowley
Publikováno v:
Genes, Chromosomes and Cancer. 21:124-130
Research on both cancer and aging has focused attention on the regulation of telomerase, the enzyme that synthesizes the ends of chromosomal DNA. To analyze the relative importance of genetic vs. environmental factors in determining telomerase induci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f9389c53789499a1b0d11774da1a58a
https://doi.org/10.1002/(sici)1098-2264(199802)21:2<124::aid-gcc8>3.0.co
https://doi.org/10.1002/(sici)1098-2264(199802)21:2<124::aid-gcc8>3.0.co
Publikováno v:
American Journal of Medical Genetics. 73:378-386
We identified 124 carriers among 4,879 patients of prenatal care providers in the Rochester region. Six factors were identified that together permitted a correct classification regarding test acceptance for 77.5% of all subjects. For those pregnant,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36a68903625ee57a1a5d2c26e1ef5f77
https://doi.org/10.1002/(sici)1096-8628(19971231)73:4<378::aid-ajmg2>3.0.co
https://doi.org/10.1002/(sici)1096-8628(19971231)73:4<378::aid-ajmg2>3.0.co