Výsledky vyhledávání - "Peter T Chivers"

Akademický článek

Point mutations in Helicobacter pylori's fur regulatory gene that alter resistance to metronidazole, a prodrug activated by chemical reduction.

Autor: Sung Sook Choi, Peter T Chivers, Douglas E Berg

Publikováno v: PLoS ONE, Vol 6, Iss 3, p e18236 (2011)

Helicobacter pylori's Fur regulatory protein controls transcription of dozens of genes in response to iron availability, acidity and oxidative stress, and affects the vigor of infection and severity of disease. It is unusual among Fur family proteins

Externí odkaz: https://doaj.org/article/c7c297f1db3e455db09122c99b322f7f

Zobrazit plný text záznamu

Glutamate Ligation in the Ni(II)- and Co(II)-Responsive Escherichia coli Transcriptional Regulator, RcnR

Autor: Michael J. Maroney, Hsin-Ting Huang, Francesco Musiani, Peter T. Chivers, Stefano Ciurli, Carolyn E. Carr

Publikováno v: Inorganic chemistry, 2017, Vol.56(11), pp.6459-6476 [Peer Reviewed Journal]

Escherichia coli RcnR (resistance to cobalt and nickel regulator, EcRcnR) is a metal-responsive repressor of the genes encoding the Ni(II) and Co(II) exporter proteins RcnAB by binding to PRcnAB. The DNA binding affinity is weakened when the cognate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070bce6fe09d7fe8f2a03523b1705d6a
https://doi.org/10.1021/acs.inorgchem.7b00527

Zobrazit plný text záznamu

Bacterial sensors define intracellular free energies for correct enzyme metalation

Autor: Maria Alessandra Martini, Nigel J. Robinson, Martin J. Warren, Peter T. Chivers, Andrew J. P. Scott, Thomas G. Huggins, Deenah Osman, Evelyne Deery, Richard Morton, Elena Lurie-Luke, Andrew W. Foster, Jonathan W. Steed, Junjun Chen, Andy Lawrence

Publikováno v: Nature chemical biology
Nature chemical biology, 2019, Vol.15(3), pp.241-249 [Peer Reviewed Journal]

There is a challenge for metalloenzymes to acquire their correct metals because some inorganic elements form more stable complexes with proteins than do others. These preferences can be overcome provided some metals are more available than others. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e67ed230a7e708ff5c078069f59b8e24

Zobrazit plný text záznamu

Nickel recognition by bacterial importer proteins

Autor: Peter T. Chivers

Publikováno v: Metallomics, 2015, Vol.7(4), pp.590-595 [Peer Reviewed Journal]

Nickel supports the growth of microbes from a variety of very different growth environments that affect nickel speciation. The mechanisms of nickel uptake and the molecular bases for the selectivity of this process are emerging. The recent surge of N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a54657a4cebfddded180d11e3a3b0fb
https://doi.org/10.1039/c4mt00310a

Zobrazit plný text záznamu

Co(II) and Ni(II) binding of the Escherichia coli transcriptional repressor RcnR orders its N terminus, alters helix dynamics, and reduces DNA affinity

Autor: Igor A. Kaltashov, Michael J. Maroney, Peter T. Chivers, Hsin-Ting Huang, Cedric E. Bobst, Jeffrey S. Iwig

Publikováno v: Journal of biological chemistry, 2018, Vol.293(1), pp.324-332 [Peer Reviewed Journal]

RcnR, a transcriptional regulator in Escherichia coli, derepresses the expression of the export proteins RcnAB upon binding Ni(II) or Co(II). Lack of structural information has precluded elucidation of the allosteric basis for the decreased DNA affin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af58f2af4f1a128cf86017fe09300a1
https://europepmc.org/articles/PMC5766909/

Zobrazit plný text záznamu

Corrigendum: Elucidation of the biosynthesis of the methane catalyst coenzyme F

Autor: Simon J, Moore, Sven T, Sowa, Christopher, Schuchardt, Evelyne, Deery, Andrew D, Lawrence, José Vazquez, Ramos, Susan, Billig, Claudia, Birkemeyer, Peter T, Chivers, Mark J, Howard, Stephen E J, Rigby, Gunhild, Layer, Martin J, Warren

Publikováno v: Nature

Summary Methane biogenesis in methanogens is mediated by methyl-coenzyme M reductase, an enzyme that is also responsible for the utilisation of methane through anaerobic methane oxidation. The enzyme employs an ancillary factor called coenzyme F430,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::db217a46d41de95e2d912c83b27c0cac
https://pubmed.ncbi.nlm.nih.gov/28225763

Zobrazit plný text záznamu

Nickel Regulation

Autor: Peter T. Chivers

Publikováno v: The Biological Chemistry of Nickel ISBN: 9781782624981

Nickel ions are required to cofactor several microbial enzymes. Transcriptionally regulated import and export systems have evolved to control cytoplasmic nickel levels and match physiological need with metal availability. In cases where there is no p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::def8a18985fbe77a2e2b0ab199c3f4b9
https://doi.org/10.1039/9781788010580-00259

Zobrazit plný text záznamu

A tight tunable range for Ni(II) sensing and buffering in cells

Autor: Peter T. Chivers, Lars-Olof Pålsson, Carl J. Patterson, Ehmke Pohl, Andrew W. Foster, Ian Cummins, Rafael Pernil, Andrew J. P. Scott, Nigel J. Robinson, Robert Pal

Publikováno v: Nature chemical biology, 2017, Vol.13(4), pp.409-414 [Peer Reviewed Journal]
ResearcherID
Nature chemical biology

The metal affinities of metal-sensing transcriptional regulators co-vary with cellular metal concentrations over more than 12 orders of magnitude. To understand the cause of this relationship, we determined the structure of the Ni(II) sensor InrS and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ad98237b5f1e466e32a72cd3f732fc3
https://doi.org/10.1038/nchembio.2310

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání