Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Peter T Beernink"'
Autor:
Nathaniel A Sands, Peter T Beernink
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1009655 (2021)
Microbial pathogens bind host complement regulatory proteins to evade the immune system. The bacterial pathogen Neisseria meningitidis, or meningococcus, binds several complement regulators, including human Factor H (FH). FH binding protein (FHbp) is
Externí odkaz:
https://doaj.org/article/969ca8f7280e44268e847c58b47b0043
Autor:
Peter T. Beernink, Cristina Di Carluccio, Roberta Marchetti, Linda Cerofolini, Sara Carillo, Alessandro Cangiano, Nathan Cowieson, Jonathan Bones, Antonio Molinaro, Luigi Paduano, Marco Fragai, Benjamin P. Beernink, Sunita Gulati, Jutamas Shaughnessy, Peter A. Rice, Sanjay Ram, Alba Silipo
Publikováno v:
JACS Au, Vol 4, Iss 7, Pp 2617-2629 (2024)
Externí odkaz:
https://doaj.org/article/3b78fa31925743b98c78dd295a7f23ec
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128185 (2015)
Factor H binding protein (FHbp) is a virulence factor used by meningococci to evade the host complement system. FHbp elicits bactericidal antibodies in humans and is part of two recently licensed vaccines. Using human complement Factor H (FH) transge
Externí odkaz:
https://doaj.org/article/ca6ad6fa5cb3448298c8c2e367578994
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135996 (2015)
Two meningococcal serogroup B vaccines contain Factor H binding protein (FHbp). Binding of Factor H (FH) to FHbp was thought to be specific for human or chimpanzee FH. However, in a previous study an amino acid polymorphism in rhesus macaque FH domai
Externí odkaz:
https://doaj.org/article/78ab1bb2778a47949601542e4696f370
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e34272 (2012)
Meningococcal factor H binding protein (fHbp) is a promising vaccine candidate. Anti-fHbp antibodies can bind to meningococci and elicit complement-mediated bactericidal activity directly. The antibodies also can block binding of the human complement
Externí odkaz:
https://doaj.org/article/680f87776b144d5fb3e2f382a7495607
Autor:
Peter T Beernink, Jutamas Shaughnessy, Rolando Pajon, Emily M Braga, Sanjay Ram, Dan M Granoff
Publikováno v:
PLoS Pathogens, Vol 8, Iss 5, p e1002688 (2012)
The binding of human complement inhibitors to vaccine antigens in vivo could diminish their immunogenicity. A meningococcal ligand for the complement down-regulator, factor H (fH), is fH-binding protein (fHbp), which is specific for human fH. Vaccine
Externí odkaz:
https://doaj.org/article/ab7aba014e1b45e4b35006bc714eb514
Autor:
Peter T. Beernink
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 16, Iss 3, Pp 703-712 (2020)
Bacteria produce surface ligands for host complement regulators including Factor H (FH), which allows the bacteria to evade immunity. Meningococcal Factor H binding protein (FHbp) is both a virulence factor and a vaccine antigen. Antibodies to FHbp c
Externí odkaz:
https://doaj.org/article/0e0025571cb847cc9579b2c6b6a34d4f
Autor:
Paul A. Liberator, Jamie Findlow, Ray Borrow, Paul Balmer, Peter T. Beernink, Christopher D. Bayliss
Publikováno v:
Vaccine
Vaccine, vol 38, iss 49
Vaccine, vol 38, iss 49
Neisseria meningitidis, the causative agent of invasive meningococcal disease (IMD), is classified into different serogroups defined by their polysaccharide capsules. Meningococcal serogroups A, B, C, W, and Y are responsible for most IMD cases, with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179d99d1a4ed1dea4da281aa915f329d
https://doi.org/10.1016/j.vaccine.2020.08.031
https://doi.org/10.1016/j.vaccine.2020.08.031
Autor:
Nathaniel A. Sands, Peter T. Beernink
Publikováno v:
PLoS pathogens, vol 17, iss 6
PLoS Pathogens, Vol 17, Iss 6, p e1009655 (2021)
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 6, p e1009655 (2021)
PLoS Pathogens
Microbial pathogens bind host complement regulatory proteins to evade the immune system. The bacterial pathogen Neisseria meningitidis, or meningococcus, binds several complement regulators, including human Factor H (FH). FH binding protein (FHbp) is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8699739c1a698b292018695b05c91a23
https://escholarship.org/uc/item/3b5150fj
https://escholarship.org/uc/item/3b5150fj
Publikováno v:
The Journal of Infectious Diseases. 219:1130-1137
BACKGROUND: Meningococcal outer membrane vesicle (OMV) vaccines are prepared with detergents to remove endotoxin, which also remove desirable antigens such as factor H binding protein (FHbp). Native OMV (NOMV) vaccines with genetically attenuated end
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::795c07d87ddf9f456e5d899f1d6f0c60
https://doi.org/10.1093/infdis/jiy609
https://doi.org/10.1093/infdis/jiy609