Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Peter T, Simpson"'
Autor:
Lingchen Liu, Jia Zhang, Scott Wood, Felicity Newell, Conrad Leonard, Lambros T. Koufariotis, Katia Nones, Andrew J. Dalley, Haarika Chittoory, Farzad Bashirzadeh, Jung Hwa Son, Daniel Steinfort, Jonathan P. Williamson, Michael Bint, Carl Pahoff, Phan T. Nguyen, Scott Twaddell, David Arnold, Christopher Grainge, Peter T. Simpson, David Fielding, Nicola Waddell, John V. Pearson
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract Background Lung cancer is a heterogeneous disease and the primary cause of cancer-related mortality worldwide. Somatic mutations, including large structural variants, are important biomarkers in lung cancer for selecting targeted therapy. Ge
Externí odkaz:
https://doaj.org/article/3e541a9800144058a28c32a39366caaa
Autor:
Andrew Causer, Xiao Tan, Xuehan Lu, Philip Moseley, Siok M. Teoh, Natalie Molotkov, Margaret McGrath, Taehyun Kim, Peter T. Simpson, Christopher Perry, Ian H. Frazer, Benedict Panizza, Rahul Ladwa, Quan Nguyen, Jazmina L. Gonzalez-Cruz
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-13 (2023)
Abstract Immune checkpoint inhibitor (ICI) therapy has had limited success (
Externí odkaz:
https://doaj.org/article/79b178e6e32c430f87e0d111d2dd01aa
Autor:
Ha-Linh Nguyen, Tatjana Geukens, Marion Maetens, Samuel Aparicio, Ayse Bassez, Ake Borg, Jane Brock, Annegien Broeks, Carlos Caldas, Fatima Cardoso, Maxim De Schepper, Mauro Delorenzi, Caroline A. Drukker, Annuska M. Glas, Andrew R. Green, Edoardo Isnaldi, Jórunn Eyfjörð, Hazem Khout, Stian Knappskog, Savitri Krishnamurthy, Sunil R. Lakhani, Anita Langerod, John W. M. Martens, Amy E. McCart Reed, Leigh Murphy, Stefan Naulaerts, Serena Nik-Zainal, Ines Nevelsteen, Patrick Neven, Martine Piccart, Coralie Poncet, Kevin Punie, Colin Purdie, Emad A. Rakha, Andrea Richardson, Emiel Rutgers, Anne Vincent-Salomon, Peter T. Simpson, Marjanka K. Schmidt, Christos Sotiriou, Paul N. Span, Kiat Tee Benita Tan, Alastair Thompson, Stefania Tommasi, Karen Van Baelen, Marc Van de Vijver, Steven Van Laere, Laura van’t Veer, Giuseppe Viale, Alain Viari, Hanne Vos, Anke T. Witteveen, Hans Wildiers, Giuseppe Floris, Abhishek D. Garg, Ann Smeets, Diether Lambrechts, Elia Biganzoli, François Richard, Christine Desmedt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Obesity is associated with an increased risk of developing breast cancer (BC) and worse prognosis in BC patients, yet its impact on BC biology remains understudied in humans. This study investigates how the biology of untreated primary BC di
Externí odkaz:
https://doaj.org/article/449fce543ad84736bc9d60953aa2df60
Autor:
Vaibhavi Joshi, Andrew Stacey, Yufan Feng, Priyakshi Kalita‐de Croft, Pascal HG Duijf, Peter T Simpson, Sunil R Lakhani, Amy E McCart Reed
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 10, Iss 2, Pp n/a-n/a (2024)
Abstract Brain metastases are secondary brain tumours characterised by their aggressive nature and poor prognosis. Breast cancer is one of the most common primary tumours in women to spread to the brain. A lack of biomarkers predicting likely spread
Externí odkaz:
https://doaj.org/article/2bd621ffce7f468c8b7dd6bbf721be3c
Autor:
David Fielding, Andrew J. Dalley, Mahendra Singh, Lakshmy Nandakumar, Vanessa Lakis, Haarika Chittoory, David Fairbairn, Ann-Marie Patch, Stephen H. Kazakoff, Kaltin Ferguson, Farzad Bashirzadeh, Michael Bint, Carl Pahoff, Jung Hwa Son, Kimberley Ryan, Alan Hodgson, Sowmya Sharma, John V. Pearson, Nicola Waddell, Sunil R. Lakhani, Gunter Hartel, Peter T. Simpson, Katia Nones
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionTumour Mutation Burden (TMB) is a potential biomarker for immune cancer therapies. Here we investigated parameters that might affect TMB using duplicate cytology smears obtained from endobronchial ultrasound transbronchial needle aspirati
Externí odkaz:
https://doaj.org/article/f59f51c4cc2242a2aa208dda6ce9e2fd
Autor:
Jodi M. Saunus, Xavier M. De Luca, Korinne Northwood, Ashwini Raghavendra, Alexander Hasson, Amy E. McCart Reed, Malcolm Lim, Samir Lal, A. Cristina Vargas, Jamie R. Kutasovic, Andrew J. Dalley, Mariska Miranda, Emarene Kalaw, Priyakshi Kalita-de Croft, Irma Gresshoff, Fares Al-Ejeh, Julia M. W. Gee, Chris Ormandy, Kum Kum Khanna, Jonathan Beesley, Georgia Chenevix-Trench, Andrew R. Green, Emad A. Rakha, Ian O. Ellis, Dan V. Nicolau, Peter T. Simpson, Sunil R. Lakhani
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-16 (2022)
Abstract Intratumoral heterogeneity is caused by genomic instability and phenotypic plasticity, but how these features co-evolve remains unclear. SOX10 is a neural crest stem cell (NCSC) specifier and candidate mediator of phenotypic plasticity in ca
Externí odkaz:
https://doaj.org/article/8a3be3a876b24ea3b406d64dc3b52fe6
Autor:
Devika Ganesamoorthy, Alan James Robertson, Wenhan Chen, Michael B. Hall, Minh Duc Cao, Kaltin Ferguson, Sunil R. Lakhani, Katia Nones, Peter T. Simpson, Lachlan J. M. Coin
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Background Circulating cell-free DNA (cfDNA) in the plasma of cancer patients contains cell-free tumour DNA (ctDNA) derived from tumour cells and it has been widely recognized as a non-invasive source of tumour DNA for diagnosis and prognosi
Externí odkaz:
https://doaj.org/article/7c33650a162849c0917d3be7602f54e8
Autor:
Jamie R. Kutasovic, Katia Nones, Vanessa Lakis, Lambros T. Koufariotis, Kaltin Ferguson, Amy E. McCart Reed, Peter T. Simpson, Sunil R. Lakhani, Helen Mar Fan, Megan Higgins, Janene Davies, Diane Payton, Lucinda Taege
Publikováno v:
Human Pathology Reports, Vol 30, Iss , Pp 300678- (2022)
Lipoblastoma-like tumour of the vulva (LLTV) is a rare soft tissue neoplasm with only nineteen reported cases to date. The clinical behaviour in all cases has been benign, with a small number of local recurrences and no incidences of metastasis descr
Externí odkaz:
https://doaj.org/article/efd40250613b4258a27005c1a6033fee
Autor:
David Fielding, FRACP, MD, Andrew J. Dalley, PhD, Mahendra Singh, FRCPA, Lakshmy Nandakumar, FRCPA, Katia Nones, PhD, Vanessa Lakis, MBioinf, Haarika Chittoory, MBiotech, Kaltin Ferguson, Farzad Bashirzadeh, FRACP, Michael Bint, FRACP, Carl Pahoff, FRACP, Jung Hwa Son, RN, Alan Hodgson, CT ASC, Sowmya Sharma, FRCPA, David Godbolt, FRCPA, Kylie Coleman, CT ASC, Lenore Whitfield, CT ASC, Nicola Waddell, PhD, Sunil R. Lakhani, FRCPA, Gunter Hartel, PhD, Peter T. Simpson, PhD
Publikováno v:
JTO Clinical and Research Reports, Vol 3, Iss 10, Pp 100403- (2022)
Introduction: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS TBNA) is an important means of obtaining a tissue for advanced lung cancer. Optimizing the EBUS TBNA needling technique is important to maintain procedural simplicit
Externí odkaz:
https://doaj.org/article/a6f1ee6dc77241f38149b13163b10713
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-16 (2021)
Abstract Invasive lobular carcinoma (ILC) is the most common of the breast cancer special types, accounting for up to 15% of all breast cancer cases. ILCs are noted for their lack of E-cadherin function, which underpins their characteristic discohesi
Externí odkaz:
https://doaj.org/article/77d4f32eabc94bbd818c882e2c1bc0c9