Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Peter T, Peachell"'
Publikováno v:
Journal of Immunotoxicology, Vol 14, Iss 1, Pp 60-65 (2017)
As part of the intracellular processes leading to mast cell and basophil activation, phosphorylation of key substrates is likely to be important. These processes, mediated by phosphatases, are responsible for regulating phosphorylation. The aim of th
Externí odkaz:
https://doaj.org/article/484b1a0d4c02436e939edeef6a65bea4
Autor:
Reza Bastan, Nahid Eskandari, Ali Mohammad Sabzghabaee, Seyyed Hamid Zarkesh Esfahani, Peter T Peachell
Publikováno v:
Journal of Research in Medical Sciences, Vol 19, Iss 10, Pp 923-927 (2014)
Background: The β2-adrenoceptor agonist, isoprenaline, is an effective inhibitor of histamine release from human lung mast cells (HLMC). Since phosphorylations of the β2-adrenoceptors are probably important in inducing desensitization, we sought to
Externí odkaz:
https://doaj.org/article/5b48e53a6bbf401c8011174a0e11bcf8
Publikováno v:
Iranian Journal of Allergy, Asthma and Immunology, Vol 13, Iss 3 (2014)
Human basophils play a key role in allergic diseases such as asthma and in a variety of immunological disorders. The generation of IL-4 and IL-13 can be induced from basophil by IgE-mediated and non-IgE-mediated mechanisms. Time and stimulus- depende
Externí odkaz:
https://doaj.org/article/9c4738a1e72746fe812d94c45e2c906a
Publikováno v:
European Journal of Pharmacology. 837:38-44
The diverse effects of histamine are mediated by discrete histamine receptors. The principal repository of histamine in the body is the mast cell. However, the effects of histamine on mast cells, especially those of human origin, have not been fully
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c43613596fbe3c76283fb61a3db9ab4
https://doi.org/10.1016/j.ejphar.2018.08.028
https://doi.org/10.1016/j.ejphar.2018.08.028
Publikováno v:
European Journal of Pharmacology. 819:225-232
Mast cells are an exceptionally rich source of prostaglandin D2 (PGD2). PGD2 is pro-inflammatory and can cause bronchoconstriction. The enzyme cyclooxygenase (COX) is central to the generation of prostanoids such as PGD2. Non-steroidal anti-inflammat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08a53fd4babdc8513c6c1b63ff674516
https://doi.org/10.1016/j.ejphar.2017.12.005
https://doi.org/10.1016/j.ejphar.2017.12.005
Publikováno v:
Advanced Biomedical Research, Vol 4, Iss 1, Pp 125-125 (2015)
Background: The cyclic nucleotides, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), are intracellular second messengers that play an important role in modulating inflammatory cells involved in allergic diseases. In ge
Externí odkaz:
https://doaj.org/article/bdedb47167924753bbacce64efebe502
Publikováno v:
Clinical & Experimental Allergy. 47:1022-1031
SummaryBackground Clinical desensitization and oral food immunotherapy are therapeutic interventions that allow individuals who react adversely to an allergen (drug or food) to be made tolerant to the allergen. However, tolerance is brief, and allerg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74715ff2996e5f82b56edfedf8e1692
https://doi.org/10.1111/cea.12912
https://doi.org/10.1111/cea.12912
Publikováno v:
Journal of Immunotoxicology, Vol 14, Iss 1, Pp 60-65 (2017)
As part of the intracellular processes leading to mast cell and basophil activation, phosphorylation of key substrates is likely to be important. These processes, mediated by phosphatases, are responsible for regulating phosphorylation. The aim of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69902dbb330336dde4271e0778bde451
https://doaj.org/article/484b1a0d4c02436e939edeef6a65bea4
https://doaj.org/article/484b1a0d4c02436e939edeef6a65bea4
Publikováno v:
European Journal of Pharmacology. 793:49-55
The principal mechanism by which bronchodilator β-adrenoceptor agonists act is to relax airways smooth muscle although they may also be anti-inflammatory. However, the extent of anti-inflammatory activity and the cell types affected by these agonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ea533f870f2112dd265a18057f5f403
https://doi.org/10.1016/j.ejphar.2016.11.005
https://doi.org/10.1016/j.ejphar.2016.11.005
Autor:
Ian Sabroe, Helen M. Marriott, Elizabeth K. Marsh, Bethany M. Hughes, Nika Khoshaein, Shao C. Sun, Alison M. Condliffe, Carl Wright, David H. Dockrell, Peter T. Peachell, Maisha Jabeen, Lynne R. Prince, Jessica Willis, Charlotte S. Burton, Abigail E Reese
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Hughes, B M, Burton, C S, Reese, A, Jabeen, M F, Wright, C, Willis, J, Khoshaein, N, Marsh, E K, Peachell, P, Sun, S C, Dockrell, D H, Marriott, H M, Sabroe, I, Condliffe, A M & Prince, L R 2019, ' Pellino-1 Regulates Immune Responses to Haemophilus influenzae in Models of Inflammatory Lung Disease ', Frontiers in Immunology, vol. 10, pp. 1721 . https://doi.org/10.3389/fimmu.2019.01721
Hughes, B M, Burton, C S, Reese, A, Jabeen, M F, Wright, C, Willis, J, Khoshaein, N, Marsh, E K, Peachell, P, Sun, S C, Dockrell, D H, Marriott, H M, Sabroe, I, Condliffe, A M & Prince, L R 2019, ' Pellino-1 Regulates Immune Responses to Haemophilus influenzae in Models of Inflammatory Lung Disease ', Frontiers in Immunology, vol. 10, pp. 1721 . https://doi.org/10.3389/fimmu.2019.01721
Non-typeable Haemophilus influenzae (NTHi) is a frequent cause of lower respiratory tract infection in people with chronic obstructive pulmonary disease (COPD). Pellino proteins are a family of E3 ubiquitin ligases that are critical regulators of TLR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::677a0851c08ed61917b3019ec3a14033
https://eprints.whiterose.ac.uk/149411/8/fimmu-10-01721.pdf
https://eprints.whiterose.ac.uk/149411/8/fimmu-10-01721.pdf
