Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Peter T, Loudon"'
Autor:
Joseph W Golden, Matthew Josleyn, Eric M Mucker, Chien-Fu Hung, Peter T Loudon, T C Wu, Jay W Hooper
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e42353 (2012)
Orthopoxviruses remain a threat as biological weapons and zoonoses. The licensed live-virus vaccine is associated with serious health risks, making its general usage unacceptable. Attenuated vaccines are being developed as alternatives, the most adva
Externí odkaz:
https://doaj.org/article/4632debba66945ce95cdba4106f684f5
Autor:
Ahmad Ahmado, Anthony A. Vugler, Paul J. Whiting, Sakina B Gooljar, Lyndon da Cruz, Tricia Harbinson, Adnan Tufail, Conor M. Ramsden, Anna Wilbrey, Amanda J. Vernon, Mark Whitlock, Kate Fynes, Julie Kerby, Odysseas Georgiadis, Juliette Steer, Mandeep S. Sagoo, Magda Bictash, Peter J. Coffey, Amanda-Jayne F. Carr, Shazeen M Hasan, Yvonne Hsu-Lin Luo, Mike Fenster, Britta Nommiste, Graham E. Holder, Anthony G. Robson, Peter T. Loudon, Julie T. Daniels, Gang Feng
Publikováno v:
Nature Biotechnology. 36:328-337
Age-related macular degeneration (AMD) remains a major cause of blindness, with dysfunction and loss of retinal pigment epithelium (RPE) central to disease progression. We engineered an RPE patch comprising a fully differentiated, human embryonic ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d2e004d8a57eadf8ae9553a3d492e47
https://doi.org/10.1038/nbt.4114
https://doi.org/10.1038/nbt.4114
Autor:
Peter T Loudon, Eric J Yager, Debbie T Lynch, Amithi Narendran, Cristy Stagnar, Anthony M Franchini, James T Fuller, Phil A White, Julia Nyuandi, Clayton A Wiley, Michael Murphey-Corb, Deborah H Fuller
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11021 (2010)
The recent H5N1 avian and H1N1 swine-origin influenza virus outbreaks reaffirm that the threat of a world-wide influenza pandemic is both real and ever-present. Vaccination is still considered the best strategy for protection against influenza virus
Externí odkaz:
https://doaj.org/article/06d933e26f1d403fb6f6b7b481d8152f
Autor:
Guido van Amerongen, Katrina Gore, Pinky Dua, Peter T. Loudon, Donal Gorman, Geert Jan Groeneveld, Richard P. Butt, Justin L. Hay, Pieter S. Siebenga
Publikováno v:
British Journal of Clinical Pharmacology. 84:301-309
Aim Inhibitors of nerve growth factor (NGF) reduce pain in several chronic pain indications. NGF signals through tyrosine kinase receptors of the tropomyosin-related kinase (Trk) family and the unrelated p75 receptor. PF-06273340 is a small molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4142431cb2a845a795c2e9f9feed198
https://doi.org/10.1111/bcp.13448
https://doi.org/10.1111/bcp.13448
Publikováno v:
Clinical Rheumatology. 35:2045-2051
The objective of these clinical studies was to assess the safety and urate lowering activity of a novel urate transporter 1 (URAT1)/ xanthine oxidase (XO) inhibitor PF-06743649 in healthy subjects and gout patients. Escalating doses of PF-06743649 or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee1110a1997d40ca4f50f13c8e4c214
https://doi.org/10.1007/s10067-016-3273-2
https://doi.org/10.1007/s10067-016-3273-2
Autor:
Franco, Di Cesare, Jessica, Mancuso, Phil, Woodward, Martin M, Bednar, Peter T, Loudon, Jin-Moo, Harris
Publikováno v:
Journal of Stroke and Cerebrovascular Diseases. 25:642-649
Background The therapeutic potential of phosphodiesterase-5 inhibitor PF-03049423 was evaluated in a phase 2, multicenter, randomized, double-blind, placebo-controlled study of subjects with acute ischemic stroke (Clinical Trial Registration Informat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3533389c96991e62586954608448bb0d
https://doi.org/10.1016/j.jstrokecerebrovasdis.2015.11.026
https://doi.org/10.1016/j.jstrokecerebrovasdis.2015.11.026
Autor:
Rachel Gurrell, Andrew Pike, Pinky Dua, R. Ian Storer, Caroline L. Benn, Peter T. Loudon, Ciara Vangjeli
Publikováno v:
Frontiers in Medicine
Frontiers in Medicine, Vol 5 (2018)
Frontiers in Medicine, Vol 5 (2018)
Gout is the most common form of inflammatory arthritis and is a multifactorial disease typically characterized by hyperuricemia and monosodium urate crystal deposition predominantly in, but not limited to, the joints and the urinary tract. The preval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbc3856a5e758de94076a1e425a61d5d
https://pubmed.ncbi.nlm.nih.gov/29904633
https://pubmed.ncbi.nlm.nih.gov/29904633
Autor:
Julia Li, J. Erik Johnson, Derek John Falconer, Kate West, Kathrin U. Jansen, Oscar Maldonado, Susanne Lang, Jim E. Eyles, Cheryl S. Kotash, Shawn R. Makinen, Phil White, Risini D. Weeratna, James R. Merson, Thomas P. Brown, Paul Wright, George J. Smith, Clare Lees, Susan E. Witko, Paul Cockle, Vidia Roopchand, Peter T. Loudon, Shakuntala Megati, Maninder K. Sidhu
Publikováno v:
Journal of Infectious Diseases. 208:319-329
Background. We evaluated the immunological responses of African green monkeys immunized with multiple F and G protein–based vaccines and assessed protection against the Memphis 37 strain of respiratory syncytial virus (RSV). Methods. Monkeys were i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d322dd2583760ad8a2e105c4aaeac2a
https://doi.org/10.1093/infdis/jit169
https://doi.org/10.1093/infdis/jit169
Publikováno v:
Innovations in clinical neuroscience. 13(9-10)
Objective. Ischemic stroke is a serious medical condition with limited therapeutic options. The evaluation of the therapeutic potential of novel pharmacological interventions is carried-out in Phase II trials. The study design, primarily intended to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5d3fce3d1c6038be317c6898fbbc0b9c
https://pubmed.ncbi.nlm.nih.gov/27974998
https://pubmed.ncbi.nlm.nih.gov/27974998
Autor:
Melanie Rieger, Vivek M. John, Mario A. Ostrowski, Lianchun Chen, Nasra Aidarus, Ingrid M. Priumboom-Brees, Mark A. Brockman, Neil C. Sheppard, Erika Benko, Keith E. Garrison, Gabor Gyenes, Shariq Mujib, Colin Kovacs, Ravi Tandon, Haihan Song, Yang Xu, Sophie Muscat-King, Peter T. Loudon, Wei Zhan, Eric Martin, R. Brad Jones, Douglas F. Nixon, Jessica Wong, David A. Goodwin, Kiera L. Clayton, Erick Duan, Vesna Mihajlovic, Nabil F. Faruk, Jonah B. Sacha, Devi SenGupta, Diana V. Hunter, Cole Stanley, Sara J. Holditch
Publikováno v:
Journal of Clinical Investigation. 122:4473-4489
The genetic diversity of HIV-1 represents a major challenge in vaccine development. In this study, we establish a rationale for eliminating HIV-1–infected cells by targeting cellular immune responses against stable human endogenous retroviral (HERV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8210f4a71c37e0ee12598887197e418
https://doi.org/10.1172/jci64560
https://doi.org/10.1172/jci64560