Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Peter Stroeken"'
A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma
Autor:
Tim van Groningen, Nurdan Akogul, Ellen M. Westerhout, Alvin Chan, Nancy E. Hasselt, Danny A. Zwijnenburg, Marloes Broekmans, Peter Stroeken, Franciska Haneveld, Gerrit K. J. Hooijer, C. Dilara Savci-Heijink, Arjan Lakeman, Richard Volckmann, Peter van Sluis, Linda J. Valentijn, Jan Koster, Rogier Versteeg, Johan van Nes
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Neuroblastoma includes adrenergic and mesenchymal cell types that can interconvert. Here, the authors show that this transdifferentiation is driven by a NOTCH feedforward loop that allows a swift transition between two semi-stable cellular states.
Externí odkaz:
https://doaj.org/article/514276fb271e42e0afc3df43c40d7742
Autor:
Rogier Versteeg, Johan van Nes, Linda J. Valentijn, Jan Koster, Tim van Groningen, Igor Adameyko, Carel J.M. van Noesel, Richard Volckmann, Danny Zwijnenburg, Peter van Sluis, Alvin Chan, Franciska Haneveld, Nurdan Akogul, Boris Bleijlevens, Nancy E. Hasselt, Jennemiek van Arkel, Arjan Lakeman, Natalia E. Nowakowska, Peter Stroeken, Mohamed Hamdi, Ellen M. Westerhout
Supplementary Data from Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f14876aaaa2f25f4335b62b0c96a3c
https://doi.org/10.1158/0008-5472.22430725.v1
https://doi.org/10.1158/0008-5472.22430725.v1
Autor:
Rogier Versteeg, Johan van Nes, Linda J. Valentijn, Jan Koster, Tim van Groningen, Igor Adameyko, Carel J.M. van Noesel, Richard Volckmann, Danny Zwijnenburg, Peter van Sluis, Alvin Chan, Franciska Haneveld, Nurdan Akogul, Boris Bleijlevens, Nancy E. Hasselt, Jennemiek van Arkel, Arjan Lakeman, Natalia E. Nowakowska, Peter Stroeken, Mohamed Hamdi, Ellen M. Westerhout
Cancer therapy frequently fails due to the emergence of resistance. Many tumors include phenotypically immature tumor cells, which have been implicated in therapy resistance. Neuroblastoma cells can adopt a lineage-committed adrenergic (ADRN) or an i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b5f661dcd417faae73e178ff2f438c5
https://doi.org/10.1158/0008-5472.c.6513703.v1
https://doi.org/10.1158/0008-5472.c.6513703.v1
Autor:
Ellen M. Westerhout, Rogier Versteeg, Jan Koster, Peter V. Sluis, Peter Stroeken, Evan E. Santo
Supplementary Methods PDF file - 114K, Includes Lentiviral constructs, Western blotting & Cell fractionation, Luciferase constructs & reporter assay, Cell Viability Assay, Microarray profiling, and TFBS enrichment analysis. Also includes Supplementar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09f32657611ba8c80998c7b941d86f6d
https://doi.org/10.1158/0008-5472.22400280
https://doi.org/10.1158/0008-5472.22400280
Autor:
Ellen M. Westerhout, Rogier Versteeg, Jan Koster, Peter V. Sluis, Peter Stroeken, Evan E. Santo
Supplementary Figure and Table Legends PDF file - 63K, Legend for Supplementary Figures S1-S5 and Supplementary Table S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e99af76b170ca3e7e434d6013fa45f0
https://doi.org/10.1158/0008-5472.22400286
https://doi.org/10.1158/0008-5472.22400286
Autor:
Ellen M. Westerhout, Rogier Versteeg, Jan Koster, Peter V. Sluis, Peter Stroeken, Evan E. Santo
Supplementary Table S1 XLS file - 186K, Genes regulated in the SY5Y microarray experiments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d3880851363df9b9aff727d4c391eec
https://doi.org/10.1158/0008-5472.22400277
https://doi.org/10.1158/0008-5472.22400277
Data from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma
Autor:
Ellen M. Westerhout, Rogier Versteeg, Jan Koster, Peter V. Sluis, Peter Stroeken, Evan E. Santo
Neuroblastoma is a pediatric tumor of the peripheral sympathetic nervous system with a highly variable prognosis. Activation of the phosphoinositide 3-kinase (PI3K)/AKT pathway in neuroblastoma is correlated with poor patient prognosis, but the preci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0686152ccd3711379b6cb4c8d70a7891
https://doi.org/10.1158/0008-5472.c.6505545
https://doi.org/10.1158/0008-5472.c.6505545
Autor:
Linda J. Valentijn, Ellen M. Westerhout, Rogier Versteeg, Alvin Chan, Arjan Lakeman, Peter van Sluis, Natalia E Nowakowska, Mohamed Hamdi, Igor Adameyko, Nancy E. Hasselt, Boris Bleijlevens, Tim van Groningen, Franciska Haneveld, Jan Koster, Carel J. M. van Noesel, Nurdan Akogul, Richard Volckmann, Peter Stroeken, Danny A. Zwijnenburg, Jennemiek van Arkel, Johan van Nes
Publikováno v:
Cancer research, 82(3), 484-496. American Association for Cancer Research Inc.
Cancer therapy frequently fails due to the emergence of resistance. Many tumors include phenotypically immature tumor cells, which have been implicated in therapy resistance. Neuroblastoma cells can adopt a lineage-committed adrenergic (ADRN) or an i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c8eca38a6b36d94471b13429c50ac12
http://www.scopus.com/inward/record.url?scp=85124056607&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85124056607&partnerID=8YFLogxK
Autor:
Ellen M. Westerhout, Mohamed Hamdi, Peter Stroeken, Natalia E. Nowakowska, Arjan Lakeman, Jennemiek van Arkel, Nancy E. Hasselt, Boris Blejlevens, Nurdan Akogul, Franciska Haneveld, Alvin Chan, Peter van Sluis, Danny Zwijnenburg, Richard Volckmann, Carel JM van Noesel, Igor Adameyko, Tim van Gronigen, Jan Koster, Linda J. Valentijn, Johan van Nes, Rogier Versteeg
Publikováno v:
Cancer Research. 82:2657-2657
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::778ed42781b46352521e5baeda345530
https://doi.org/10.1158/0008-5472.can-22-1915
https://doi.org/10.1158/0008-5472.can-22-1915
Autor:
Sofie Mohlin, Peter Stroeken, van Nes J, Franciska Haneveld, Alvin Chan, Niklasson Cu, Daniel Bexell, van Sluis P, Nurdan Akogul, Jan Koster, Rogier Versteeg, Linda J. Valentijn, Frank Westermann, Nancy E. Hasselt, Selina Jansky, Ellen M. Westerhout, van Groningen T, Arjan Lakeman, von Stedingk K, Sven Påhlman, Caroline Wigerup, Danny A. Zwijnenburg, Mohamed Hamdi, Igor Adameyko
Neuroblastoma is a pediatric tumor of the adrenergic sympathetic lineage. Most high risk neuroblastoma go in complete clinical remission by chemotherapy, which is subsequently complemented by retinoic acid (RA) maintenance therapy. However, by unreso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9038fb701339c80be36df7f06f1394dd
https://doi.org/10.1101/2021.05.18.444639
https://doi.org/10.1101/2021.05.18.444639