Zobrazeno 1 - 10
of 347
pro vyhledávání: '"Peter Storz"'
Autor:
Heike R. Döppler, Peter Storz
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Pancreatic inflammation is a risk factor for the development of pancreatic cancer. Increased presence of inflammatory macrophages can be found in response to a KRAS mutation in acinar cells or in response to experimentally-induced pancreatitis. Infla
Externí odkaz:
https://doaj.org/article/0667ce792d074985abb6873e7d2f83dc
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4726 (2024)
Pancreatic ductal adenocarcinoma (PDAC) can originate from acinar-to-ductal metaplasia (ADM). Pancreatic acini harboring oncogenic Kras mutations are transdifferentiated to a duct-like phenotype that further progresses to become pancreatic intraepith
Externí odkaz:
https://doaj.org/article/3a1d94349e5e4a25bc7033b7e23731e0
Autor:
Peter Storz
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
During development of pancreatic cancer macrophage-mediated inflammatory processes and the formation of cancerous lesions are tightly connected. Based on insight from mouse models we provide an overview on the functions of classically-activated pro-i
Externí odkaz:
https://doaj.org/article/666498608e7f46d1aee02288e87dd6a0
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106820- (2023)
Summary: The innate immune system has a key role in pancreatic cancer initiation, but the specific contribution of different macrophage populations is still ill-defined. While inflammatory (M1) macrophages have been shown to drive acinar-to-ductal me
Externí odkaz:
https://doaj.org/article/ee1aeaca9d56411a9f284027194122df
Autor:
Alicia K. Fleming Martinez, Heike R. Döppler, Ligia I. Bastea, Brandy H. Edenfield, Geou-Yarh Liou, Peter Storz
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104327- (2022)
Summary: Desmoplasia around pancreatic lesions is a barrier for immune cells and a hallmark of developing and established pancreatic cancer. However, the contribution of the innate immune system to this process is ill-defined. Using the KC mouse mode
Externí odkaz:
https://doaj.org/article/91998440ba57446fb25042eefda52ac9
Autor:
Sikander Ailawadhi, Ricardo D. Parrondo, Navnita Dutta, Bing Han, Gina Ciccio, Yesesri Cherukuri, Victoria R. Alegria, Betsy R. LaPlant, Vivek Roy, Taimur Sher, Brett Edwards, Stephanie Lanier, Alak Manna, Keisha Heslop, Thomas Caulfield, Emir Maldosevic, Peter Storz, Rami Manochakian, Yan Asmann, Asher A. Chanan-Khan, Aneel Paulus
Publikováno v:
Cancers, Vol 15, Iss 2, p 477 (2023)
Bcl-2 and Mcl-1 proteins play a role in multiple myeloma (MM) cell survival, for which targeted inhibitors are being developed. AT-101 is an oral drug, which disrupts Bcl-2 and Mcl-1 function, impedes mitochondrial bioenergetic processes and induces
Externí odkaz:
https://doaj.org/article/1026c2828c8c483d903c832b6fef943e
Autor:
Veethika Pandey, Alicia Fleming-Martinez, Ligia Bastea, Heike R Doeppler, Jillian Eisenhauer, Tam Le, Brandy Edenfield, Peter Storz
Publikováno v:
eLife, Vol 10 (2021)
The development of pancreatic cancer requires recruitment and activation of different macrophage populations. However, little is known about how macrophages are attracted to the pancreas after injury or an oncogenic event, and how they crosstalk with
Externí odkaz:
https://doaj.org/article/bb9e0bd0593542cf8d2f5f67178433c4
Autor:
Alicia K. Fleming Martinez, Heike R. Döppler, Ligia I. Bastea, Brandy Edenfield, Tushar Patel, Michael Leitges, Geou-Yarh Liou, Peter Storz
Publikováno v:
iScience, Vol 24, Iss 1, Pp 102019- (2021)
Summary: Doublecortin-like kinase 1 (DCLK1)-positive pancreatic cancer stem cells develop at a precancerous stage and may contribute to the lack of efficacy of pancreatic cancer therapy. Although PanIN cells express oncogenic KRas and have an increas
Externí odkaz:
https://doaj.org/article/97c1c4b06bc6435e98af436af67fd633
Publikováno v:
Antioxidants, Vol 11, Iss 1, p 137 (2022)
Pancreatic acinar-to-ductal metaplasia (ADM) is a reversible process that occurs after pancreatic injury, but becomes permanent and leads to pancreatic lesions in the presence of an oncogenic mutation in KRAS,. While inflammatory macrophage-secreted
Externí odkaz:
https://doaj.org/article/c414ddc89f2d4b27afe03dcdaf090ff2
Autor:
Geou-Yarh Liou, Ligia Bastea, Alicia Fleming, Heike Döppler, Brandy H. Edenfield, David W. Dawson, Lizhi Zhang, Nabeel Bardeesy, Peter Storz
Publikováno v:
Cell Reports, Vol 19, Iss 7, Pp 1322-1333 (2017)
The contributions of the innate immune system to the development of pancreatic cancer are still ill defined. Inflammatory macrophages can initiate metaplasia of pancreatic acinar cells to a duct-like phenotype (acinar-to-ductal metaplasia [ADM]), whi
Externí odkaz:
https://doaj.org/article/3ff5843d69ad48958952a7a78e9fe61c