Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Peter Staller"'
Autor:
Mareike Berlak, Zuzanna Makowska, Filippos Klironomos, Julia Kuehnlenz, Atanas Kamburov, Andreas Steffen, Martin Lange, Barbara Nicke, Ralf Lesche, Peter Staller, Charlotte Kopitz, Jan Naujoks
Publikováno v:
Cancer Research. 83:6089-6089
The Hippo signaling cascade is a major pathway that integrates a broad spectrum of mechanosensory signals at the plasma membrane and regulates response via control of cell proliferation, self-renewal, differentiation, and apoptosis. Dysregulation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d97e88c3074aa7701ef4af05c2e60d1b
https://doi.org/10.1158/1538-7445.am2023-6089
https://doi.org/10.1158/1538-7445.am2023-6089
Autor:
Lisette Potze, Ekaterina Nevedomskaya, Benjamin Bader, Julia Kuehnlenz, Claudia Luther, Peter Staller, Jan Naujoks, Andreas Steffen, Atanas Kamburov, Anna Anurin, Anne Buttgereit, Ralf Lesche, Barbara Nicke, Stefan Prechtl, Martin Lange
Publikováno v:
Molecular Cancer Research. 18:A29-A29
Aberrant activation of the Hippo pathway effectors YAP1/TAZ promotes cell proliferation and tumorigenesis. To identify novel regulators of YAP1/TAZ in cancer, we established a FACS-based screening system monitoring YAP1/TAZ activity in MDA-MB-231 bre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bd4f7d906a8f01a33b0b5497553b99e
https://doi.org/10.1158/1557-3125.hippo19-a29
https://doi.org/10.1158/1557-3125.hippo19-a29
Autor:
Gabriela Paroni, Marco Bolis, Mineko Terao, Maddalena Fratelli, Lars Ole Gerlach, Adriana Zanetti, Peter Staller, Enrico Garattini, Kristian Helin, Richard M. Neve, Paolo Ubezio
Publikováno v:
Oncogene. 38(15)
Targeting of histone methylation has therapeutic potential in oncology. Here, we provide proof-of-principle that pharmacological inhibition of KDM5 histone-demethylases is a new strategy for the personalized treatment of HER2+ breast cancer. The anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5ae3ad1e48c46845ccb244da9ab153c
https://pubmed.ncbi.nlm.nih.gov/30538297
https://pubmed.ncbi.nlm.nih.gov/30538297
Autor:
Peter Birk Rasmussen, Peter Staller
Publikováno v:
Epigenomics. 6:277-286
There is growing evidence for a causal role of the KDM5 family of histone demethylases in human cancer. In particular, KDM5A (JARID1A/RBP2) and KDM5B (JARID1B/PLU1) contribute to cancer cell proliferation, reduce the expression of tumor suppressor ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af217616a3dd8f77cf73e88acd9b1b3
https://doi.org/10.2217/epi.14.14
https://doi.org/10.2217/epi.14.14
Autor:
Luke Gaughan, Kanagasabai Sahadevan, Dominic Jones, Alejandra Mantilla, Jacqueline Stockley, Steven Darby, Lynsey Rogerson, Dhuha Alkharaif, Kelly Coffey, Peter Staller, Rakesh Heer, Craig N. Robson, Claudia A. Ryan-Munden, Daniel O'Neill
Publikováno v:
Nucleic Acids Research
The androgen receptor (AR) is a key molecule involved in prostate cancer (PC) development and progression. Post-translational modification of the AR by co-regulator proteins can modulate its transcriptional activity. To identify which demethylases mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ebab10b6ce2d026363fb71d5ad8587b
https://doi.org/10.1093/nar/gkt106
https://doi.org/10.1093/nar/gkt106
Autor:
Andreas Kjaer, Tina Binderup, Rehannah Borup, Bjørn Quistorff, Caroline Bouchard, Klaus T. Jensen, Göran Landberg, Kim Steen Jensen, Hinke A.B. Multhaupt, Ib Therkelsen, Elise Nilsson, Peter Staller
Publikováno v:
The EMBO Journal. 30:4554-4570
Exposure of metazoan organisms to hypoxia engages a metabolic switch orchestrated by the hypoxia-inducible factor 1 (HIF-1). HIF-1 mediates induction of glycolysis and active repression of mitochondrial respiration that reduces oxygen consumption and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::534bb729c1267d2b064895d2888c8038
https://doi.org/10.1038/emboj.2011.323
https://doi.org/10.1038/emboj.2011.323
Autor:
Bryce K. Allen, Donat Alpar, Viren Amin, Fazila Asmar, Nagi G. Ayad, Anne-Marie Baird, Louise J. Barber, Becky A.S. Bibby, Emma Bolderson, Philippe Bouvet, Frédéric Catez, Leandro Cerchietti, Snehajyoti Chatterjee, Taiping Chen, Andreas I. Constantinou, Stuart J. Conway, Dashyant Dhanak, Jean-Jacques Diaz, Marc Diederich, Xinmin Fan, Brendan Ffrench, Michael F. Gallagher, Marco Gerlinger, Steven D. Gore, Steven G. Gray, Kirsten Grønbæk, David S. Hewings, Holger Heyn, Zhe Jin, Stephanie Kaypee, Yutaka Kondo, Tapas K. Kundu, Florian Laforêts, Matthew W. Lawless, Stephen G. Maher, Somnath Mandal, Virginie Marcel, Aleksandar Milosavljevic, Hannah L. Moody, Atsushi Natsume, Thomas B. Nicholson, Kenneth J. O’Byrne, Shane O’Grady, John J. O’Leary, Fumiharu Ohka, Vitor Onuchic, Vineet Pande, Clara Penas, Li-Xia Peng, Benet Pera, Antoinette Sabrina Perry, Olga Piskareva, Chara A. Pitta, David J. Pocalyko, Thomas Prebet, Chao-Nan Qian, Glen Reid, Derek J. Richard, Timothy P.C. Rooney, Michael Schnekenburger, Alexandra Søgaard, Peter Staller, Raymond L. Stallings, Vasileios Stathias, Gabriel Therizols, Nicolas Veland, Casey M. Wright, Xiaojing Zhang, Wei Zhu, Jiaqi Qian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72dd990a6c8ae573244de2d41706a718
https://doi.org/10.1016/b978-0-12-800206-3.00033-1
https://doi.org/10.1016/b978-0-12-800206-3.00033-1
Autor:
Peter Staller
There is growing evidence for a causal role of epigenetic factors in human cancer. Genes that control chromatin structure and cellular identity via epigenetic programs can exert tumor suppressor and oncogenic functions. Different alterations such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df7b32d8c392d1615ad289fb20a32e1e
https://doi.org/10.1016/b978-0-12-800206-3.00020-3
https://doi.org/10.1016/b978-0-12-800206-3.00020-3
Autor:
Holger Moch, Jitka Sulitkova, Peter Staller, Wilhelm Krek, Edward J. Oakeley, Joanna Lisztwan
Publikováno v:
Nature. 425:307-311
Organ-specific metastasis is governed, in part, by interactions between chemokine receptors on cancer cells and matching chemokines in target organs. For example, malignant breast cancer cells express the chemokine receptor CXCR4 and commonly metasta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5b17e752a8a18c8e96ce81e62266591
https://doi.org/10.1038/nature01874
https://doi.org/10.1038/nature01874
Autor:
Tarik Möröy, Joan Massagué, Jiri Lukas, Martin Eilers, Frank Hänel, Karen Peukert, Peter Staller, Holger Karsunky, Jiri Bartek, Joan Seoane, Astrid Kiermaier
Publikováno v:
Nature Cell Biology. 3:392-399
Deregulated expression of c-myc can induce cell proliferation in established cell lines and in primary mouse embryonic fibroblasts (MEFs), through a combination of both transcriptional activation and repression by Myc. Here we show that a Myc-associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc65dcd31433e12628d70ce69d355544
https://doi.org/10.1038/35070076
https://doi.org/10.1038/35070076