Mutation and drug-specific intracellular accumulation of EGFR predict clinical responses to tyrosine kinase inhibitors

Autor: Maurice de Wit, Ya Gao, Darlene Mercieca, Iris de Heer, Bart Valkenburg, Martin E. van Royen, Joachim Aerts, Peter Sillevis Smitt, Pim French

Publikováno v: EBioMedicine, Vol 56, Iss , Pp 102796- (2020)

Background: Clinical responses to EGFR tyrosine kinase inhibitors (TKIs) are restricted to tumors harboring specific activating mutations and even then, not all tyrosine kinase inhibitors provide clinical benefit. All TKIs however, effectively inhibi

Externí odkaz: https://doaj.org/article/4d3332bf8c9340df889230410d065f40

Glioma progression is shaped by genetic evolution and microenvironment interactions

Autor: Frederick S. Varn, Kevin C. Johnson, Jan Martinek, Jason T. Huse, MacLean P. Nasrallah, Pieter Wesseling, Lee A.D. Cooper, Tathiane M. Malta, Taylor E. Wade, Thais S. Sabedot, Daniel Brat, Peter V. Gould, Adelheid Wöehrer, Kenneth Aldape, Azzam Ismail, Santhosh K. Sivajothi, Floris P. Barthel, Hoon Kim, Emre Kocakavuk, Nazia Ahmed, Kieron White, Indrani Datta, Hyo-Eun Moon, Steven Pollock, Christine Goldfarb, Ga-Hyun Lee, Luciano Garofano, Kevin J. Anderson, Djamel Nehar-Belaid, Jill S. Barnholtz-Sloan, Spyridon Bakas, Annette T. Byrne, Fulvio D’Angelo, Hui K. Gan, Mustafa Khasraw, Simona Migliozzi, D. Ryan Ormond, Sun Ha Paek, Erwin G. Van Meir, Annemiek M.E. Walenkamp, Colin Watts, Tobias Weiss, Michael Weller, Karolina Palucka, Lucy F. Stead, Laila M. Poisson, Houtan Noushmehr, Antonio Iavarone, Roel G.W. Verhaak, Kristin D. Alfaro, Samirkumar B. Amin, David M. Ashley, Christoph Bock, Andrew Brodbelt, Ketan R. Bulsara, Ana Valeria Castro, Jennifer M. Connelly, Joseph F. Costello, John F. de Groot, Gaetano Finocchiaro, Pim J. French, Anna Golebiewska, Ann C. Hau, Chibo Hong, Craig Horbinski, Kasthuri S. Kannan, Mathilde CM. Kouwenhoven, Anna Lasorella, Peter S. LaViolette, Keith L. Ligon, Allison K. Lowman, Shwetal Mehta, Hrvoje Miletic, Annette M. Molinaro, Ho Keung Ng, Simone P. Niclou, Johanna M. Niers, Joanna J. Phillips, Raul Rabadan, Ganesh Rao, Guido Reifenberger, Nader Sanai, Susan C. Short, Peter Sillevis Smitt, Andrew E. Sloan, Marion Smits, James M. Snyder, Hiromichi Suzuki, Ghazaleh Tabatabai, Georgette Tanner, William H. Tomaszewski, Michael Wells, Bart A. Westerman, Helen Wheeler, Jichun Xie, W.K. Alfred Yung, Gelareh Zadeh, Junfei Zhao, Roel GW. Verhaak

Publikováno v: Cell, 185(12), 2184-2199.e16. Cell Press
Cell
Cell, vol 185, iss 12
The GLASS Consortium 2022, ' Glioma progression is shaped by genetic evolution and microenvironment interactions ', Cell, vol. 185, no. 12, pp. 2184-2199.e16 . https://doi.org/10.1016/j.cell.2022.04.038
Cell, 185(12), 2184-2199.e16. CELL PRESS

The factors driving therapy resistance in diffuse glioma remain poorly understood. To identify treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA sequencing data from the temporally separated tumor pairs of 304 adult patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36aa8231290284197e37208bfab4dbba
https://research.vumc.nl/en/publications/312bbb0a-1328-4405-bfbe-cce4f07b8a67

Abstract 2071: Protein aggregate formation predicts clinical responses to EGFR tyrosine kinase inhibitors

Autor: Pim French, Ya Gao, Maurice de Wit, Darlene Mercieca, Iris de Heer, Bart Valkenburg, Martin van Royen, Joachim Aerts, Peter Sillevis Smitt

Publikováno v: Cancer Research. 79:2071-2071

Although many tumours depend on EGFR signalling for growth, benefit from EGFR tyrosine kinase inhibitors (TKIs) is restricted to patients harboring specific activating mutations and even then restricted to specific TKIs only. We here performed functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::845591b0f8011dec5ce07984524f11bf
https://doi.org/10.1158/1538-7445.am2019-2071

Antistofgeassocieerde Encephalitis: Handvatten Voor Diagnostiek En Behandeling

Autor: Agnes Sonderen, Marco Schreurs, Marienke de Bruijn, Peter Sillevis Smitt, Maarten Titulaer

Publikováno v: Tijdschrift voor Neurologie en Neurochirurgie, 117(2), 78-88
EUR Research Portal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6b2264ec8bf9cef2c438e9b150bba8bc
https://pure.eur.nl/en/publications/bf4ed205-d016-44de-aed9-70c8019e6e44

Long-term potentiation of mGluR1 activity by depolarization-induced Homer1a in mouse cerebellar Purkinje neurons

Autor: Itsunari, Minami, Mineko, Kengaku, Peter Sillevis, Smitt, Ryuichi, Shigemoto, Tomoo, Hirano

Publikováno v: The European journal of neuroscience. 17(5)

Metabotropic glutamate receptor 1 (mGluR1) plays a crucial role in synaptic plasticity and motor learning in the cerebellum. We have studied activity-dependent changes in mGluR1 function in mouse cultured Purkinje neurons. Depolarizing stimulation po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::67553fddd6922680faf528088a178a5f
https://pubmed.ncbi.nlm.nih.gov/12653978