Erratum for Brunschwig et al., 'UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria'

Autor: Tanya Paquet, David A. Fidock, Efrem Abay, Iñigo Angulo-Barturen, Kigbafori D. Silué, Diego Gonzàlez Cabrera, Mathew Njoroge, Leslie J. Street, Rintis Noviyanti, Karen L. White, Grennady Wirjanata, Cristina Donini, Michael J Witty, Nina Lawrence, Dalu Mancama, Lyn-Marie Birkholtz, Claire Le Manach, Sergio Wittlin, Ric N. Price, María Belén Jiménez-Díaz, Lubbe Wiesner, Jutta Marfurt, Didier Leroy, David Waterson, Peter Siegl, Christel Brunschwig, Paul V. Fish, Aloysius T. Nchinda, Manu Vanaerschot, Jacob A. McPhail, Mariëtte van der Watt, Dale Taylor, Susan A. Charman, Gregory S. Basarab, Carmen de Kock, Esperanza Herreros, John E. Burke, Suresh Solapure, Kennan C. Marsh, Francisco-Javier Gamo, Kelly Chibale, Theresa L. Coetzer, James Duffy, Rosemary Rochford, Janette Reader, Paolo Denti, Dennis A. Smith, Benjamin Blasco

Publikováno v: Antimicrobial Agents and Chemotherapy. 62

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65fbee621a580f76b6953115ab78b9e3
https://doi.org/10.1128/aac.01941-18

Evaluation of the QT effect of a combination of piperaquine and a novel anti‐malarial drug candidate OZ439, for the treatment of uncomplicated malaria

Autor: Peter Siegl, Stephen Toovey, Fiona Macintyre, Bart Laurijssens, Georg Ferber, Stephan Duparc, Borje Darpo

Publikováno v: British Journal of Clinical Pharmacology

Aims The aim was to investigate the QT effect of a single dose combination regimen of piperaquine phosphate (PQP) and a novel aromatic trioxolane, OZ439, for malaria treatment. Methods Exposure–response (ER) analysis was performed on data from a pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac5f719c793ffd36ca7bc720f1f011f7
https://doi.org/10.1111/bcp.12680

Relevance of a standard food model in combination with electronic jaw movement recording on human mastication pattern analysis

Autor: Haymo Gruber, Peter Siegl, G. Slavicek, Mikhael Soykher, Marina Soykher

Publikováno v: Advances in Bioscience and Biotechnology. :68-78

The aim of this paper is to describe the possibilities of analyzing human mastication. The development of a standardized food model is presented. Based on the findings of a systematic literature search an elastic food model was created with the aim o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d7aa1e925a2559a62b86a256e252c9a
https://doi.org/10.4236/abb.2010.12011

A novel multiple-stage antimalarial agent that inhibits protein synthesis

Autor: Beatriz, Baragaña, Irene, Hallyburton, Marcus C S, Lee, Neil R, Norcross, Raffaella, Grimaldi, Thomas D, Otto, William R, Proto, Andrew M, Blagborough, Stephan, Meister, Grennady, Wirjanata, Andrea, Ruecker, Leanna M, Upton, Tara S, Abraham, Mariana J, Almeida, Anupam, Pradhan, Achim, Porzelle, Torsten, Luksch, María Santos, Martínez, Judith M, Bolscher, Andrew, Woodland, Suzanne, Norval, Fabio, Zuccotto, John, Thomas, Frederick, Simeons, Laste, Stojanovski, Maria, Osuna-Cabello, Paddy M, Brock, Tom S, Churcher, Katarzyna A, Sala, Sara E, Zakutansky, María Belén, Jiménez-Díaz, Laura Maria, Sanz, Jennifer, Riley, Rajshekhar, Basak, Michael, Campbell, Vicky M, Avery, Robert W, Sauerwein, Koen J, Dechering, Rintis, Noviyanti, Brice, Campo, Julie A, Frearson, Iñigo, Angulo-Barturen, Santiago, Ferrer-Bazaga, Francisco Javier, Gamo, Paul G, Wyatt, Didier, Leroy, Peter, Siegl, Michael J, Delves, Dennis E, Kyle, Sergio, Wittlin, Jutta, Marfurt, Ric N, Price, Robert E, Sinden, Elizabeth A, Winzeler, Susan A, Charman, Lidiya, Bebrevska, David W, Gray, Simon, Campbell, Alan H, Fairlamb, Paul A, Willis, Julian C, Rayner, David A, Fidock, Kevin D, Read, Ian H, Gilbert

Publikováno v: Nature, 522, 315-20
Nature, 522, 7556, pp. 315-20
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid

Contains fulltext : 155278.pdf (Publisher’s version ) (Closed access) There is an urgent need for new drugs to treat malaria, with broad therapeutic potential and novel modes of action, to widen the scope of treatment and to overcome emerging drug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::650155b8830359ee22f2a3f3f91f5354
https://doi.org/10.1038/nature14451

Quinolone-3-Diarylethers: A New Class of Antimalarial Drug

Autor: Jessica Anne Steuten, Santiago Ferrer, Jeremy N. Burrows, Sandra Duffy, R. Matthew Cross, Rintis Noviyanti, Robert E. Sinden, Joanne M. Morrisey, Susan A. Charman, R. Kiplin Guy, Akhil B. Vaidya, Francisco-Javier Gamo, María Belén Jiménez-Díaz, Jutta Marfurt, Yuexin Li, Isaac P. Forquer, Jane X. Kelly, Dennis E. Kyle, Clemens H. M. Kocken, Peter Siegl, Laura M. Sanz, Roman Manetsch, Michael W. Mather, Ian Bathurst, Anne-Marie Zeeman, Vicky M. Avery, Eileen Ryan, Karen L. White, David M. Shackleford, Esperanza Herreros, Fabián E. Sáenz, Michael J. Delves, Michael K. Riscoe, Alexis N. LaCrue, Boni F. Sebayang, Iñigo Angulo-Barturen, Aaron Nilsen, Tina Mutka, Grennady Wirjanata, Ric N. Price, Rolf W. Winter

Publikováno v: Science translational medicine

The goal for developing new antimalarial drugs is to find a molecule that can target multiple stages of the parasite's life cycle, thus impacting prevention, treatment, and transmission of the disease. The 4(1H)-quinolone-3-diarylethers are selective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e06da36528ed6a76f7c51b0fff0fdb8b
https://doi.org/10.1126/scitranslmed.3005029