Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Peter Sheldrake"'
Autor:
Sheelagh Frame, Chiara Saladino, Craig MacKay, Butrus Atrash, Peter Sheldrake, Edward McDonald, Paul A Clarke, Paul Workman, David Blake, Daniella Zheleva
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0234103 (2020)
Cyclin-dependent kinases (CDKs) contribute to the cancer hallmarks of uncontrolled proliferation and increased survival. As a result, over the last two decades substantial efforts have been directed towards identification and development of pharmaceu
Externí odkaz:
https://doaj.org/article/dbfd5392fe3847fb90cbeeea7636d886
Autor:
Simon R Stockwell, Georgina Platt, S Elaine Barrie, Georgia Zoumpoulidou, Robert H Te Poele, G Wynne Aherne, Stuart C Wilson, Peter Sheldrake, Edward McDonald, Mathilde Venet, Christelle Soudy, Frédéric Elustondo, Laurent Rigoreau, Julian Blagg, Paul Workman, Michelle D Garrett, Sibylle Mittnacht
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e28568 (2012)
Human cancers often contain genetic alterations that disable G1/S checkpoint control and loss of this checkpoint is thought to critically contribute to cancer generation by permitting inappropriate proliferation and distorting fate-driven cell cycle
Externí odkaz:
https://doaj.org/article/921c0f22c6cd45cb99c4eb1f472162a4
Autor:
Paul Workman, Paul A. Clarke, Nan Chi Wan, Melanie Valenti, Stephen Shuttleworth, Peter Sheldrake, Edward McDonald, Alexander Zhyvoloup, Nahid Saghir, Anthony Robson, Giles Pergl-Wilson, Letitia Lensun, Alan T. Henley, Angela Hayes, Francesca Di Stefano, Alexis De Haven Brandon, Sharon Gowan, Adrian Folkes, Irina Chuckowree, Gary Box, Sonia Alix, Sonal Patel, Suzanne A. Eccles, Florence I. Raynaud
The phosphatidylinositide 3-kinase pathway is frequently deregulated in human cancers and inhibitors offer considerable therapeutic potential. We previously described the promising tricyclic pyridofuropyrimidine lead and chemical tool compound PI-103
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085970df8f01140213c017be9fe8aaa7
https://doi.org/10.1158/1535-7163.c.6532217
https://doi.org/10.1158/1535-7163.c.6532217
Autor:
Paul Workman, Paul A. Clarke, Nan Chi Wan, Melanie Valenti, Stephen Shuttleworth, Peter Sheldrake, Edward McDonald, Alexander Zhyvoloup, Nahid Saghir, Anthony Robson, Giles Pergl-Wilson, Letitia Lensun, Alan T. Henley, Angela Hayes, Francesca Di Stefano, Alexis De Haven Brandon, Sharon Gowan, Adrian Folkes, Irina Chuckowree, Gary Box, Sonia Alix, Sonal Patel, Suzanne A. Eccles, Florence I. Raynaud
Supplementary Figure 1 from Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b69a6d0bf7df52af3de6589e9ad5e0
https://doi.org/10.1158/1535-7163.22486067.v1
https://doi.org/10.1158/1535-7163.22486067.v1
Autor:
Paul Workman, Paul A. Clarke, Nan Chi Wan, Melanie Valenti, Stephen Shuttleworth, Peter Sheldrake, Edward McDonald, Alexander Zhyvoloup, Nahid Saghir, Anthony Robson, Giles Pergl-Wilson, Letitia Lensun, Alan T. Henley, Angela Hayes, Francesca Di Stefano, Alexis De Haven Brandon, Sharon Gowan, Adrian Folkes, Irina Chuckowree, Gary Box, Sonia Alix, Sonal Patel, Suzanne A. Eccles, Florence I. Raynaud
Supplementary Figure 3C from Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c866c66e69073421c00311e11a606c
https://doi.org/10.1158/1535-7163.22486061.v1
https://doi.org/10.1158/1535-7163.22486061.v1
Autor:
Paul Workman, Paul A. Clarke, Nan Chi Wan, Melanie Valenti, Stephen Shuttleworth, Peter Sheldrake, Edward McDonald, Alexander Zhyvoloup, Nahid Saghir, Anthony Robson, Giles Pergl-Wilson, Letitia Lensun, Alan T. Henley, Angela Hayes, Francesca Di Stefano, Alexis De Haven Brandon, Sharon Gowan, Adrian Folkes, Irina Chuckowree, Gary Box, Sonia Alix, Sonal Patel, Suzanne A. Eccles, Florence I. Raynaud
Supplementary Table 1 from Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4af932823949bf9230e37a31da950e4b
https://doi.org/10.1158/1535-7163.22486052.v1
https://doi.org/10.1158/1535-7163.22486052.v1
Autor:
Paul Workman, Paul A. Clarke, Nan Chi Wan, Melanie Valenti, Stephen Shuttleworth, Peter Sheldrake, Edward McDonald, Alexander Zhyvoloup, Nahid Saghir, Anthony Robson, Giles Pergl-Wilson, Letitia Lensun, Alan T. Henley, Angela Hayes, Francesca Di Stefano, Alexis De Haven Brandon, Sharon Gowan, Adrian Folkes, Irina Chuckowree, Gary Box, Sonia Alix, Sonal Patel, Suzanne A. Eccles, Florence I. Raynaud
Supplementary Figure 2 from Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e805e180fd509a9ec2ce653e2f2de8e
https://doi.org/10.1158/1535-7163.22486064
https://doi.org/10.1158/1535-7163.22486064
Autor:
David Blake, Peter Sheldrake, Chiara Saladino, Butrus Atrash, Sheelagh Frame, Edward McDonald, Craig MacKay, Paul A. Clarke, Daniella Zheleva, Paul Workman
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0234103 (2020)
PLoS ONE
PLoS ONE
Cyclin-dependent kinases (CDKs) contribute to the cancer hallmarks of uncontrolled proliferation and increased survival. As a result, over the last two decades substantial efforts have been directed towards identification and development of pharmaceu
Autor:
James A. H. Gilburt, Hajrah Sarkar, Peter Sheldrake, Julian Blagg, Liming Ying, Charlotte A. Dodson
Publikováno v:
Angewandte Chemie. 129:11567-11572
Autor:
Peter Sheldrake, Russell Linke
Originally published in 1979 Accountability in Higher Education contains the first comprehensive analysis of accountability in Australian higher education. The contributors systematically examine organisation and practice in the Australian higher edu