Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Peter Sguigna"'
Publikováno v:
Journal of the neurological sciences. 430
Publikováno v:
Multiple Sclerosis and Related Disorders. 46:102460
Anti-DPPX encephalitis is an increasingly recognized cause of neurological disability. We describe a case of a 44 year-old woman who presented to our facility with the chief complaint of confusion, weight loss, and a visual disturbance. Multidirectio
Publikováno v:
Multiple sclerosis and related disorders. 27
Objective To describe 2 atypical cases with Anti-MOG antibody related demyelinating syndrome. Methodology Case series. Results We present two cases. Case 1 is an 18-year-old woman who presented with headache, blurred vision, and papilledema and was i
Autor:
Teresa C. Frohman, Shiv Saidha, Darrel Conger, Steven L. Galetta, Peter Sguigna, Laura J. Balcer, Peter A. Calabresi, Amy Conger, Eric J. Kildebeck, Ethan Meltzer, Adnan Subei, Randy H. Kardon, Robert L. Rennaker, Benjamin S. Frohman, Ashley N. Frohman, Shin C. Beh, Elliot M. Frohman, Marlen Lucero
Publikováno v:
JAMA neurology. 74(5)
Importance A neurophysiologic signature of the melanopsin-mediated persistent constriction phase of the pupillary light reflex may represent a surrogate biomarker for the integrity of the retinohypothalamic tract, with potential utility for investiga
Autor:
Esther Melamed, Kathleen Costello, Dina A. Jacobs, Ashlea Lucas, Andrew D. Goodman, Teresa C. Frohman, Edward Fox, Etsegenet F. Tizazu, Peter Sguigna, Leorah Freeman, Robert P. Lisak, Ethan Meltzer, Gabriel Pardo, Christopher Perrone, Scott S. Zamvil, Elliot M. Frohman, Matthew S. Parsons
Publikováno v:
Neurology(R) neuroimmunology & neuroinflammation, vol 6, iss 4
Neurology® Neuroimmunology & Neuroinflammation
Neurology® Neuroimmunology & Neuroinflammation
A 54-year-old woman presented with complaints of myalgias, fatigue, and progressive leg weakness of several weeks duration, followed by acute loss of vision in her left eye. Her medical history was notable for long-standing systemic lupus erythematos
Publikováno v:
Current treatment options in neurology. 18(6)
Patients with progressive forms of multiple sclerosis have various symptoms which affect their quality of life significantly including depression, cognitive decline, sleep changes, bladder dysfunction, sexual dysfunction, and spasticity. Despite rece
Autor:
Peter Sguigna, Paul Litvak, Kevin F. Kia, Shirley O’Leary, Fides M. Pacheco, Karanjit S. Kooner, Tresa Zacharias, Ellen Marder, Rehana Z. Hussain, Olaf Stüve
Publikováno v:
Journal of neurology. 263(3)
Sphingosine 1-phosphate (S1P) is a signaling molecule that binds to five G protein-coupled receptors (Proc Natl Acad Sci USA 108:751-756, 2011). Modulation of these receptors has been associated with pleiotropic biological effects in the immune, card
Publikováno v:
Proceedings of the National Academy of Sciences. 108:20503-20508
Accumulation of sterols in membranes of the endoplasmic reticulum (ER) leads to the accelerated ubiquitination and proteasomal degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a rate-limiting enzyme in synthesis of cholesterol and nons
Publikováno v:
The Journal of Biological Chemistry
The endoplasmic reticulum (ER)-associated degradation (ERAD) pathway in the yeast Saccharomyces cerevisiae is mediated by two membrane-bound ubiquitin ligases, Doa10 and Hrd1. These enzymes are found in distinct multiprotein complexes that allow them