Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Peter Seubert"'
Autor:
Marcia B. Podlisny, Martin Citron, Patricia Amarante, Robin Sherrington, Weiming Xia, Jimin Zhang, Thekla Diehl, George Levesque, Paul Fraser, Christian Haass, Edward H.M. Koo, Peter Seubert, Peter St. George-Hyslop, David B. Teplow, Dennis J. Selkoe
Publikováno v:
Neurobiology of Disease, Vol 3, Iss 4, Pp 325-337 (1997)
Humans inheriting missense mutations in thepresenilin(PS)1 and -2 genes undergo progressive cerebral deposition of the amyloid β-protein at an early age and develop a clinically and pathologically severe form of familial Alzheimer's disease (FAD). B
Externí odkaz:
https://doaj.org/article/f93f2c49920043a197e4ad3dfbc6922d
Autor:
Jonathan S Wall, Stephen J Kennel, Angela Williams, Tina Richey, Alan Stuckey, Ying Huang, Sallie Macy, Robert Donnell, Robin Barbour, Peter Seubert, Dale Schenk
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52686 (2012)
The monoclonal antibody 2A4 binds an epitope derived from a cleavage site of serum amyloid protein A (sAA) containing a -Glu-Asp- amino acid pairing. In addition to its reactivity with sAA amyloid deposits, the antibody was also found to bind amyloid
Externí odkaz:
https://doaj.org/article/1ffe065ab13e43e99ff425143f1fbae9
Autor:
Eliezer Masliah, Edward Rockenstein, Michael Mante, Leslie Crews, Brian Spencer, Anthony Adame, Christina Patrick, Margarita Trejo, Kiren Ubhi, Troy T Rohn, Sarah Mueller-Steiner, Peter Seubert, Robin Barbour, Lisa McConlogue, Manuel Buttini, Dora Games, Dale Schenk
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19338 (2011)
Dementia with Lewy bodies (DLB) and Parkinson's Disease (PD) are common causes of motor and cognitive deficits and are associated with the abnormal accumulation of alpha-synuclein (α-syn). This study investigated whether passive immunization with a
Externí odkaz:
https://doaj.org/article/278122a2cf34484d955e2231ae5639e8
Autor:
Dale Schenk, Dong Li, Peter Seubert, Adrienne L. Orr, Jesse E. Hanson, Sarah J Wright, Adam Klotz, Daniel V. Madison
Publikováno v:
Neuron. 82:1334-1345
It has been widely reported that β-amyloid peptide (Aβ) blocks long-term potentiation (LTP) of hippocampal synapses. Here we show evidence that Aβ more potently blocks the potentiation of excitatory post-synaptic potential (EPSP) -spike coupling (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ef514cc035afdc6280c1381f037d8ce
https://doi.org/10.1016/j.neuron.2014.04.039
https://doi.org/10.1016/j.neuron.2014.04.039
Autor:
Gene Kinney, Schenk Dale B, Stuart Friedrich, Peter Seubert, Michael D. Fox, Ted Yednock, Frederique Bard
Publikováno v:
Experimental Neurology. 238:38-43
Passive immunization with anti-Aβ antibodies leads to the reduction of AD-like neuropathology in transgenic mice. Previously we showed that anti-Aβ antibodies enter the brain and bind to amyloid plaques. Now using (125)I-labeled 3D6, the mouse pare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13329b75aa12efe655929479ae9bdc68
https://doi.org/10.1016/j.expneurol.2012.07.022
https://doi.org/10.1016/j.expneurol.2012.07.022
Autor:
Michael K. Lee, Schenk Dale B, Peter Seubert, Hadar Feinberg, Robin Barbour, Kelly Johnson-Wood, Menelas N. Pangalos, Amita Goel, Irene Griswold-Prenner, Linnea Diep, William I. Weis, Jingzhi Li, Davinder Gill, John P. Anderson, J. Steven Jacobsen, Thomas A. Comery, Donald Walker, Nicolas Piot, Guriqbal S. Basi, Angela Widom, Anthony Partridge, Jeanne Baker, Farshid Oshidari, Katerina Grantcharova
Publikováno v:
Journal of Biological Chemistry. 285:3417-3427
Immunotherapy targeting of amyloid beta (Abeta) peptide in transgenic mouse models of Alzheimer disease (AD) has been widely demonstrated to resolve amyloid deposition as well as associated neuronal, glial, and inflammatory pathologies. These success
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c127e58115c08c9d0fd96b9cce7c07
https://doi.org/10.1074/jbc.m109.045187
https://doi.org/10.1074/jbc.m109.045187
Autor:
Tamie J. Chilcote, Peter Seubert, Tracy Cole, Ferdie Soriano, Robin Barbour, Michael D. Fox, John P. Anderson, Kristin Kling, Kelly Banducci, Linnea Diep, Jason Goldstein
Publikováno v:
Neurodegenerative Diseases. 5:55-59
Background: α-Synuclein has been directly linked to Parkinson’s disease etiology by mutations in and multiplication of its gene that result in a familial form of Parkinson’s disease. α-Synuclein has been detected in blood, and was found to be e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa9abcfa359020b18b434042152050be
https://doi.org/10.1159/000112832
https://doi.org/10.1159/000112832
Autor:
Peter Seubert, Ruth Motter, J. Randall Slemmon, Sashi Nadanaciva, Ashley Cook, Florentina Catana, Cory L. Painter
Publikováno v:
Journal of Chromatography B. 846:24-31
The measurement of amyloid beta peptides (Abeta) in blood and plasma is expected to be a useful biomarker as potential therapeutics designed to lower Abeta peptide enter clinical trials. Many reports have suggested that Abeta could bind to substances
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c1730779d89025da42769eb24ac9641
https://doi.org/10.1016/j.jchromb.2006.08.003
https://doi.org/10.1016/j.jchromb.2006.08.003
Autor:
Christina Vlachouli, James A. R. Nicoll, James Neal, Antony James Bayer, Dora Games, David Wilkinson, Dale Schenk, Delphine Boche, Petrina Thompson, Edward Barton, Clive Holmes, Isidro Ferrer, Peter Seubert
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 65:1040-1048
Neuropathologic examination of 3 patients with Alzheimer disease in the Elan Pharmaceuticals trial using antibodies specific for different Abeta species showed in one case, 4 months after the immunization, evidence of a stage of active plaque clearan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2307ec9d5fe92c9b96fa56060bbfdc4f
https://doi.org/10.1097/01.jnen.0000240466.10758.ce
https://doi.org/10.1097/01.jnen.0000240466.10758.ce
Autor:
Manuel Buttini, Robin Barbour, Marion S. Buckwalter, Dora Games, Tony Wyss-Coray, Peter Seubert, Dale Schenk, Bronwen S. Coleman
Publikováno v:
The Journal of Neuroscience. 26:11437-11441
Immunotherapy targeting the amyloid β (Aβ) peptide is a novel therapy under investigation for the treatment of Alzheimer's disease (AD). A clinical trial using Aβ1–42(AN1792) as the immunogen was halted as a result of development of meningoencep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d48f366ebc371fdd54357d6c7c6abff
https://doi.org/10.1523/jneurosci.2436-06.2006
https://doi.org/10.1523/jneurosci.2436-06.2006