Simultaneous quantitation of methotrexate and its two main metabolites in biological fluids by a novel solid-phase extraction procedure using high-performance liquid chromatography

Autor: Olof Beck, Peter Seideman, Freidoun Albertioni, Carsten Peterson, Charlotte Ulrikka Rask, Birgitta Pettersson

Publikováno v: Albertioni, F, Pettersson, B, Beck, O, Rask, C, Seideman, P & Peterson, C 1995, ' Simultaneous quantitation of methotrexate and its two main metabolites in biological fluids by a novel solid-phase extraction procedure using high-performance liquid chromatography ', Journal of Chromatography B: Biomedical Sciences and Applications, vol. 665, no. 1, pp. 163-170 . https://doi.org/10.1016/0378-4347(94)00507-2

We have developed an assay for the simultaneous determination of methotrexate (MTX) and its main metabolites, 7-hydroxymethotrexate (7-OHMTX) and 2,4-diamino-N10-methylpteroic acid (DAMPA) in plasma, urine and saliva meeting the requirement of rapidi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8024b83116e4d827e2b3c4981d1ccb3
https://doi.org/10.1016/0378-4347(94)00507-2

The stereoselective disposition of the enantiomers of ibuprofen in blood, blister and synovial fluid

Autor: Km M. Williams, F. Lohrer, Mw W. Duncan, Peter Seideman, Ro O. Day, Gg G. Graham

Publikováno v: British Journal of Clinical Pharmacology. 38:221-227

1. A sensitive, stereospecific assay using gas chromatography-mass spectrometry (GC/MS) was established to measure the concentrations of the enantiomers of ibuprofen in small volumes (50 microliters) of blister fluid. 2. The concentrations of the ena

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf521f7c329b33b01e73b2c0cb10e124
https://doi.org/10.1111/j.1365-2125.1994.tb04345.x

The pharmacokinetics of methotrexate and its 7-hydroxy metabolite in patients with rheumatoid arthritis

Autor: Olof Beck, Peter Seideman, Staffan Eksborg, Mona Wennberg

Publikováno v: British Journal of Clinical Pharmacology. 35:409-412

1. The pharmacokinetics of MTX and its 7-hydroxy metabolite (7-OHMTX) were investigated in nine patients with rheumatoid arthritis (RA). Each patient received 15 mg MTX i.v., i.m. and p.o. after an overnight fast in a randomized cross-over design. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9072a6d708f1255e9aa7cb75510cfa8b
https://doi.org/10.1111/j.1365-2125.1993.tb04158.x

Enhanced Fcgamma receptor I, alphaMbeta2 integrin receptor expression by monocytes and neutrophils in rheumatoid arthritis: interaction with platelets

Autor: Andreia, Bunescu, Peter, Seideman, Rodica, Lenkei, Klas, Levin, Nils, Egberg

Publikováno v: The Journal of rheumatology. 31(12)

To investigate platelet and leukocyte activation and interaction in patients with rheumatoid arthritis (RA) and the effect of methotrexate (MTX) or anti-tumor necrosis factor-a (TNF-a) treatment on these variables.Four-color flow cytometry analysis w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d6e7c22316f3e4b59e305ebf803fa039
https://pubmed.ncbi.nlm.nih.gov/15570633

Pharmacokinetics of ibuprofen enantiomers in plasma and suction blister fluid in healthy volunteers

Autor: Richard O. Day, J. S. Walker, Romualda D. Knihinicki, Peter Seideman

Publikováno v: Journal of pharmaceutical sciences. 82(8)

After a single oral dose of (R,S)-ibuprofen (1200 mg) to five healthy volunteers, paired plasma and blister fluid concentrations of drug were determined by a stereospecific HPLC assay. A pharmacokinetic model that incorporated blister fluid as a sepa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e5f95809089e0fc6f6fefd5b6925131
https://pubmed.ncbi.nlm.nih.gov/8377114