Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Peter Scheurich"'
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198203 (2018)
Dysregulation of the mitochondrial signaling pathway of apoptosis induction represents a major hurdle in tumor therapy. The objective of the presented work was to investigate the role of the intrinsic (mitochondrial) apoptotic pathway in the non-smal
Externí odkaz:
https://doaj.org/article/9e232127ea1d4ef3932132940bc1d1b5
Autor:
Florian Kälble, Janine Damaske, Danijela Heide, Iris Arnold, Fabian Richter, Olaf Maier, Ulrich Eisel, Peter Scheurich, Klaus Pfizenmaier, Martin Zeier, Vedat Schwenger, Julia Ranzinger
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0163314 (2016)
Chronic inflammatory conditions during peritoneal dialysis (PD)-treatment lead to the impairment of peritoneal tissue integrity. The resulting structural and functional reorganization of the peritoneal membrane diminishes ultrafiltration rate and the
Externí odkaz:
https://doaj.org/article/4e33af30d62344f98179baa89837025b
Autor:
Fabian Richter, Timo Liebig, Eric Guenzi, Andreas Herrmann, Peter Scheurich, Klaus Pfizenmaier, Roland E Kontermann
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72156 (2013)
BACKGROUND: Selective inhibition of TNFR1 signaling holds the potential to greatly reduce the pro-inflammatory activity of TNF, while leaving TNFR2 untouched, thus allowing for cell survival and tissue homeostasis. ATROSAB is a humanized antagonistic
Externí odkaz:
https://doaj.org/article/4f53bc5bdaa4432bb1434b52d5f6a3fa
Autor:
Simon Neumann, Tobias Bidon, Marcus Branschädel, Anja Krippner-Heidenreich, Peter Scheurich, Malgorzata Doszczak
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42526 (2012)
TNF-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor (TNF) ligand family that exerts its apoptotic activity in human cells by binding to two transmembrane receptors, TRAILR1 and TRAILR2. In cells co-expressing both r
Externí odkaz:
https://doaj.org/article/b4efd875d417403ab0654027ab7a4e69
Autor:
Michael A Dengler, Annette M Staiger, Matthias Gutekunst, Ute Hofmann, Malgorzata Doszczak, Peter Scheurich, Matthias Schwab, Walter E Aulitzky, Heiko van der Kuip
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25139 (2011)
In response to deregulated oncogene activation, mammalian cells activate disposal programs such as programmed cell death. To investigate the mechanisms behind this oncogenic stress response we used Bcr-Abl over-expressing cells cultivated in presence
Externí odkaz:
https://doaj.org/article/30003634020a4e90af9989fc1b2c9212
Autor:
Julia Ranzinger, Amin Rustom, Marcus Abel, Julia Leyh, Lars Kihm, Margarete Witkowski, Peter Scheurich, Martin Zeier, Vedat Schwenger
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e29537 (2011)
A well-known role of human peritoneal mesothelial cells (HPMCs), the resident cells of the peritoneal cavity, is the generation of an immune response during peritonitis by activation of T-cells via antigen presentation. Recent findings have shown tha
Externí odkaz:
https://doaj.org/article/9ed6cb64585944528d9a56cef668a42e
Autor:
Roman Fischer, Olaf Maier, Martin Siegemund, Harald Wajant, Peter Scheurich, Klaus Pfizenmaier
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27621 (2011)
Tumor necrosis factor (TNF) plays a dual role in neurodegenerative diseases. Whereas TNF receptor (TNFR) 1 is predominantly associated with neurodegeneration, TNFR2 is involved in tissue regeneration and neuroprotection. Accordingly, the availability
Externí odkaz:
https://doaj.org/article/4645e466297f47b6bfeb1e00558e5fe5
Autor:
Rebekka Schlatter, Kathrin Schmich, Ima Avalos Vizcarra, Peter Scheurich, Thomas Sauter, Christoph Borner, Michael Ederer, Irmgard Merfort, Oliver Sawodny
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 12, p e1000595 (2009)
Apoptosis is regulated by several signaling pathways which are extensively linked by crosstalks. Boolean or logical modeling has become a promising approach to capture the qualitative behavior of such complex networks. Here we built a large-scale lit
Externí odkaz:
https://doaj.org/article/e4e3e6b1791f41698a2aaca0b610bf16
Cell cycle progression and transmitotic apoptosis resistance promote escape from extrinsic apoptosis
Autor:
Peter Scheurich, Frank Allgöwer, Daniela Stöhr, Markus Rehm, Isabel Heinrich, Karsten Kuritz, Nadine Pollak, Aline Lindner, Lorena Decker, Jacques S Fritze, Jannis Stadager, Dirke Imig, Stephan A. Eisler
Publikováno v:
Journal of Cell Science. 134
Extrinsic apoptosis relies on TNF-family receptor activation by immune cells or receptor-activating drugs. Here, we monitored cell cycle progression at a resolution of minutes to relate apoptosis kinetics and cell-to-cell heterogeneities in death dec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d58a0d8bb5223055bc6ed248d9a2252
https://doi.org/10.1242/jcs.258966
https://doi.org/10.1242/jcs.258966
Autor:
Nadine Pollak, Jacques S Fritze, Peter Scheurich, Karsten Kuritz, Heinrich I, Daniela Stöhr, Stadager J, Frank Allgöwer, Morrison (Rehm) M, Stephan A. Eisler, Lindner A, Dirke Imig
Extrinsic apoptosis relies on TNF-family receptor activation by immune cells or receptor-activating biologics. Here, we monitored cell cycle progression at minutes resolution to relate apoptosis kinetics and cell-to-cell heterogeneities in death deci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c10c31887ebdd075fce8b628a8c953b7
https://doi.org/10.1101/2021.02.26.433034
https://doi.org/10.1101/2021.02.26.433034
