Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Peter Sajonz"'
Autor:
Paul Fernandez, Weifeng Hu, Peter Sajonz, Karel J. M. Brands, Jennifer R. Foley, Peter R. Mullens, Lushi Tan, George Zhou, Nadine Bremeyer, Robert D. Wilson, Sarah E. Brewer, Daniel J. Muzzio, Guoyue Zhou, Debra J. Wallace, Khateeta M. Emerson, Richard Desmond, Stephen P. Keen, Carl A. Baxter
Publikováno v:
Organic Process Research & Development. 15:831-840
Compound (1) a poly(ADP-ribose)polymerase (PARP) inhibitor has been made by a fit-for-purpose large-scale synthesis using either a classical resolution or chiral chromatographic separation. The development and relative merits of each route are discus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3f282e65dc38e0c3e06307cc29e3d06
https://doi.org/10.1021/op2000783
https://doi.org/10.1021/op2000783
Autor:
George N. Nikov, Grace Bi, Benito Munoz, Matthew G. Stanton, Matthew T. Tudge, Richard E. Middleton, Jamie L. Crispino, Peter Sajonz, Mark S. Shearman, Black Regina M, Minilik Angagaw, Paula Andrade, Eric Fan, Flobert Tanga, Jonathan C. Cruz, Alexander A. Szewczak, Nirah H. Shomer, Bethany Hughes, Sanjiv J. Shah, Georgia Farris, Christopher Hamblett, Jed L. Hubbs, David L. Sloman, Candia M. Kenific
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:755-758
We report herein a novel series of difluoropiperidine acetic acids as modulators of gamma-secretase. Synthesis of 2-aryl-3,3-difluoropiperidine analogs was facilitated by a unique and selective beta-difluorination with Selectfluor. Compounds 1f and 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7392b77aec791c32df48952dbb130dde
https://doi.org/10.1016/j.bmcl.2009.11.034
https://doi.org/10.1016/j.bmcl.2009.11.034
Autor:
Steven Marcinko, Frank Bernardoni, Peter Sajonz, Ahmed Abrahim, Jia Zang, Roy Helmy, Claire Lee
Publikováno v:
Chromatographia. 70:1561-1567
Irreproducibility during initial development of a high performance liquid chromatography method is seldom investigated in a thorough and careful manner when working in an industrial setting. For a drug project in the early developmental stages, the L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47013d20caf5391e10f89ceed2b80f22
https://doi.org/10.1365/s10337-009-1381-8
https://doi.org/10.1365/s10337-009-1381-8
Autor:
Yongkui Sun, Thorsten Rosner, Scott Shultz, Wes Schafer, Xiaoyi Gong, Leonard William, Peter Sajonz, Christopher J. Welch
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 31:2296-2304
Rapid chiral method development using microfluidic multiparallel HPLC is illustrated with several examples of ‘real world’ pharmaceutical intermediates for which speed was critical for successful process development. It is shown that this rapid c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::591b84c52a7dd1f07a848150b381080b
https://doi.org/10.1080/10826070802281653
https://doi.org/10.1080/10826070802281653
Autor:
Derek W. Henderson, Wes Schafer, Christopher J. Welch, Leonard William, Peter Sajonz, Glenn Spencer, Frank Bernardoni
Publikováno v:
Organic Process Research & Development. 12:674-677
The use of microscale HPLC for piloting the large-scale preparative chromatographic resolution of the enantiomers of a chiral pharmaceutical intermediate is reported with an example of a millionfold scale-up from a 300 μm i.d. column to a 30 cm i.d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7d76627b3d05e5631e0b65ef7bc673e
https://doi.org/10.1021/op800107u
https://doi.org/10.1021/op800107u
Publikováno v:
Journal of Chromatography A. 1194:205-212
The adsorption isotherm was determined for phenol in methanol/water on a C-8 stationary phase using frontal analysis in staircase mode, assuming different total column porosities, from 1 to 87%. Each set of adsorption isotherm data, with a certain co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bd7773176df32e4e1f7f1eebbc3abe5
https://doi.org/10.1016/j.chroma.2008.04.053
https://doi.org/10.1016/j.chroma.2008.04.053
Publikováno v:
Journal of Chromatography A. 1189:19-31
The impact of a realistic error in the column hold-up time on the determination of the adsorption isotherm model was systematically investigated. Frontal analysis and the inverse method were used for the accurate determination of the adsorption isoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcf31b254d396f3e2a630c1b569028ca
https://doi.org/10.1016/j.chroma.2007.10.032
https://doi.org/10.1016/j.chroma.2007.10.032
Autor:
Derek W. Henderson, Benjamin T. Dorner, Christopher J. Welch, Leonard William, John Y. L. Chung, Jennifer Albaneze-Walker, Frederick W. Hartner, Peter Sajonz, Karla G. Childers
Publikováno v:
Organic Process Research & Development. 12:81-87
A screening approach for identifying adsorbents and conditions for selective removal of colored impurities from solutions of pharmaceutical intermediates is described. In this method, a variety of process adsorbents are evaluated using a combination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bc2ce05a9f36e98f06edb15f3a84104
https://doi.org/10.1021/op700191z
https://doi.org/10.1021/op700191z
Publikováno v:
Chromatographia. 64:635-640
The separation of periodate, iodate and iodide can be easily achieved by HPLC on a C-18 column with a mobile phase consisting of acetonitrile and aqueous phosphoric acid, without the need of any mobile phase additives that are often employed. All thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::998a1aa9ea8012b9ea527b5ef75b3162
https://doi.org/10.1365/s10337-006-0082-9
https://doi.org/10.1365/s10337-006-0082-9
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 29:2185-2200
The Eksigent Express 800 8 channel and the Nanostream Veloce 24 channel microfluidic HPLC systems were compared for their utility in providing high throughput chromatographic analysis to support a growing demand in pharmaceutical process research. Cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b54ebe975d25db52dcb016bfefd6094
https://doi.org/10.1080/10826070600832889
https://doi.org/10.1080/10826070600832889