Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Peter S. Wolf"'
Calcium Entry Blockers (CEBs) are a new class of drugs which have been pushing back the frontiers of science and medicine for almost two decades. This report reviews some of the wealth of chemical, biological and clinical data describing the discover
Publikováno v:
Journal of Pharmacological Methods. 15:235-243
The ability to continuously monitor the delicate balance between blood flow and oxygen consumption would be a great asset in the study of myocardial ischemia. The present study was performed, in anesthetized dogs, to validate the use of encased polar
Autor:
John W. Hubbard, Ronald D. Smith, Jeffrey T. Shapiro, Peter S. Wolf, Gabor Kaley, Thomas H. Hintze
Publikováno v:
Drug Development Research. 17:17-21
The cardiovascular effects of ascending doses (0.03, 0.1, 0.3, 1.0, and 3.0 mg/kg i.v.) of two angiotensin l-converting enzyme (ACE) inhibitors, REV 6207 and enalapril, were assessed in conscious furosemide-treated (3 mg/kg s.c.) monkeys. Both ACE in
Publikováno v:
Drug Development Research. 12:221-231
The cardiostimulatory effects of celiprolol were evaluated in isolated cat cardiac tissue to elucidate the contributions of beta versus alpha adrenoceptor mechanisms. Racemic celiprolol increased the spontaneous rate of cat right atria and the develo
Autor:
Ronald D. Smith, Peter S. Wolf
Publikováno v:
Cardiovascular Drug Reviews. 2:19-35
Publikováno v:
Drug Development Research. 9:159-169
Celiprolol is a new cardioselective beta adrenoceptor antagonist presently undergoing worldwide clinical traits. The present study was undertaken to further evaluate the beta antagonist and hemodynamic effects of celiprolol compared to the known beta
Autor:
Peter S Wolf, Tedd Pruss
Publikováno v:
American Heart Journal. 106:208-211
Indapamide is a new indoline antihypertensive diuretic agent whose chemical structure differs substantially from those of the thiazides. The hydrophobic indoline moiety of indapamide confers a lipid solubility to the molecule that is 5 to 80 times gr
Publikováno v:
Pharmacology. 39:1-10
Celiprolol, propranolol or saline were administered to separate groups (n = 5-6) of anesthetized dogs in which a critical stenosis was applied to the circumflex coronary artery for 90 min and then reperfused for 30 min. Test drugs were administered a
Publikováno v:
Journal of Cardiovascular Pharmacology. 11:538-542
The roles of vasopressin and angiotensin II in the regulation of peripheral vascular tone were investigated in control rats and in rats with chronic (15 weeks) aortic stenosis, by intravenous application of a specific antagonist to the vascular recep
Publikováno v:
Pharmacology. 33:139-147
Anoxia has been shown to potentiate the constrictor effects of 5-hydroxytryptamine (5HT) in isolated vascular tissue. In the present study, canine coronary arterial rings were incubated with various treatments and exposed to 5HT (4 X 10(-7) M) and an