Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Peter S. Kutchukian"'
Autor:
Lingling Shen, Jian Fang, Lulu Liu, Fei Yang, Jeremy L. Jenkins, Peter S. Kutchukian, He Wang
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-17 (2024)
Abstract We present a user-friendly molecular generative pipeline called Pocket Crafter, specifically designed to facilitate hit finding activity in the drug discovery process. This workflow utilized a three-dimensional (3D) generative modeling metho
Externí odkaz:
https://doaj.org/article/3862345979da4f6a9f6a00a5c376a88d
Autor:
Ji Zhang, Eric S. Muise, Seongah Han, Peter S. Kutchukian, Philippe Costet, Yonghua Zhu, Yanqing Kan, Haihong Zhou, Vinit Shah, Yongcheng Huang, Ashmita Saigal, Taro E. Akiyama, Xiao-Lan Shen, Tian-Quan Cai, Kashmira Shah, Ester Carballo-Jane, Emanuel Zycband, Lan Yi, Ye Tian, Ying Chen, Jason Imbriglio, Elizabeth Smith, Kristine Devito, James Conway, Li-Jun Ma, Maarten Hoek, Iyassu K. Sebhat, Andrea M. Peier, Saswata Talukdar, David G. McLaren, Stephen F. Previs, Kristian K. Jensen, Shirly Pinto
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 4, Pp 100056- (2020)
Summary: Fibrosis, or the accumulation of extracellular matrix, is a common feature of many chronic diseases. To interrogate core molecular pathways underlying fibrosis, we cross-examine human primary cells from various tissues treated with TGF-β, a
Externí odkaz:
https://doaj.org/article/063a70c64d8f4793abcfad76e4a93d9a
Autor:
Elliott B. Nickbarg, Graham Smith, Matthew Richards, Peter Saradjian, Jeannie T. Lee, Patrick J. Curran, Daniel J. Klein, Rodrigo Aguilar, Ali Nahvi, Chad Chamberlin, John P. Santa Maria, Julja Burchard, Noreen F. Rizvi, Joel A. Klappenbach, Peter J. Dandliker, Peter S. Kutchukian
Publikováno v:
SLAS Discovery. 25:384-396
Although the potential value of RNA as a target for new small molecule therapeutics is becoming increasingly credible, the physicochemical properties required for small molecules to selectively bind to RNA remain relatively unexplored. To investigate
Autor:
Ian M. Bell, Steve S. Carroll, Paula J. Hancock, Richard J. O. Barnard, M. Katharine Holloway, David M. Tellers, Alan Hruza, Gregory C. Adam, Christopher D. Cox, Peter S. Kutchukian, Matthew Tudor, Jing Li, B. Wesley Trotter, Anthony W. Shaw, Corey Strickland, Marina Bukhtiyarova, Scott E. Wolkenberg, David A. Powell, Erica M. Cook, Ivan Cornella-Taracido, Philip M. McKenna
Publikováno v:
ACS Med Chem Lett
[Image: see text] By employing a phenotypic screen, a set of compounds, exemplified by 1, were identified which potentiate the ability of histone deacetylase inhibitor vorinostat to reverse HIV latency. Proteome enrichment followed by quantitative ma
Autor:
David G. McLaren, Lan Yi, Shirly Pinto, Ye Tian, Kristian K. Jensen, Kristine Devito, Elizabeth Smith, Philippe Costet, Iyassu K. Sebhat, Stephen F. Previs, Emanuel Zycband, James Conway, Eric S. Muise, Seongah Han, Yongcheng Huang, Kashmira Shah, Ying Chen, Jason E. Imbriglio, Ji Zhang, Vinit Shah, Peter S. Kutchukian, Haihong Zhou, Tian-Quan Cai, Li-Jun Ma, Yonghua Zhu, Yanqing Kan, Taro E. Akiyama, Ester Carballo-Jane, Maarten Hoek, Xiaolan Shen, Saswata Talukdar, Andrea M. Peier, Ashmita Saigal
Publikováno v:
Cell Reports Medicine
Cell Reports Medicine, Vol 1, Iss 4, Pp 100056-(2020)
Cell Reports Medicine, Vol 1, Iss 4, Pp 100056-(2020)
Summary Fibrosis, or the accumulation of extracellular matrix, is a common feature of many chronic diseases. To interrogate core molecular pathways underlying fibrosis, we cross-examine human primary cells from various tissues treated with TGF-β, as
Autor:
Peter S Kutchukian, Nadya Y Vasilyeva, Jordan Xu, Mika K Lindvall, Michael P Dillon, Meir Glick, John D Coley, Natasja Brooijmans
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48476 (2012)
Medicinal chemists' "intuition" is critical for success in modern drug discovery. Early in the discovery process, chemists select a subset of compounds for further research, often from many viable candidates. These decisions determine the success of
Externí odkaz:
https://doaj.org/article/8278d8c8630b4124807ed15a08836945
Autor:
Meir Glick, Sean J. Fox, Charlie Chang, Erica Cook, Robert P. Sheridan, David M. Tellers, Iain M. Wallace, Dante A. Pertusi, Anne Mai Wassermann, Richard J. O. Barnard, Huijun Wang, Peter S. Kutchukian
Publikováno v:
Drug Discovery Today. 23:151-160
Increasing amounts of biological data are accumulating in the pharmaceutical industry and academic institutions. However, data does not equal actionable information, and guidelines for appropriate data capture, harmonization, integration, mining, and
Autor:
Michelle F. Homsher, Louis Locco, Shannon L. Stahler, Michael Weber, Jennifer E. Nothstein, Eleftheria N. Finger, Evelyn Boots, Mee Ra Heo, Amita Patel, Gregory O'Donnell, Alex Wolicki, Michael F.A. Finley, J. Christopher Culberson, Paul Zuck, Juncai Meng, Kenneth Roberts, David J. Bell, Peter S. Kutchukian, Gregory C. Adam, Carissa Quinn, Patrick Cocchiarella, Meir Glick, S. Alex May, Victor N. Uebele, Edward Hudak, Brian Squadroni, Daniel Riley, Andrew Rusinko, Kelli Solly, Michelle Hartnett, Dante A. Pertusi, Adam Amoss, Anthony Kreamer, Tara White, Anne Mai Wassermann
Publikováno v:
SLAS Discovery. 22:995-1006
High-throughput screening (HTS) is a widespread method in early drug discovery for identifying promising chemical matter that modulates a target or phenotype of interest. Because HTS campaigns involve screening millions of compounds, it is often desi
Autor:
Peter Saradjian, John P. Santa Maria, Peter J. Dandliker, Chad Chamberlin, Gregory C. Adam, Nicholas Murgolo, Clifton E. Barry, Elliott B. Nickbarg, Paul Zuck, Peter S. Kutchukian, Charles G. Garlisi, Lihu Yang, Yumi Park, Helena I. Boshoff, Katherine Young, David B. Olsen, Meir Glick, Michael D. Altman
Publikováno v:
ACS Chemical Biology. 12:2448-2456
Though phenotypic and target-based high-throughput screening approaches have been employed to discover new antibiotics, the identification of promising therapeutic candidates remains challenging. Each approach provides different information, and unde
Autor:
Daniel A. DiRocco, Bing Li, Spencer D. Dreher, Shane W. Krska, Tim Cernak, Eric Streckfuss, Peter S. Kutchukian, Ian W. Davies, Petr Vachal, James F. Dropinski, Louis-Charles Campeau, Kevin D. Dykstra
Publikováno v:
Chem. Sci.. 7:2604-2613
Major new advances in synthetic chemistry methods are typically reported using simple, non-standardized reaction substrates, and reaction failures are rarely documented. This makes the evaluation and choice of a synthetic method difficult. We report