Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Peter S. Griffin"'
Autor:
Peter S. Griffin, Jonathan D. Roth, Jennifer Athanacio, James L. Trevaskis, David G. Parkes, Carrie Wittmer
Publikováno v:
Obesity Science & Practice
SummaryObjective Co-administration of amylin and leptin induces synergistic and clinically meaningful (>10%) weight loss that is attenuated as the degree of obesity increases. We explored whether calorie restriction (CR) could restore amylin/leptin s
Autor:
David G. Maggs, Leigh MacConell, Carol Wysham, Ming Zhou, Michael E. Trautmann, Peter S. Griffin
Publikováno v:
Mayo Clinic Proceedings. 90:356-365
Objective To evaluate the 5-year efficacy and safety of once weekly exenatide. Patients and Methods The Diabetes Therapy Utilization: Researching Changes in A1C, Weight and Other Factors Through Intervention with Exenatide Once Weekly (DURATION-1) ra
Autor:
Brent A. Neuschwander-Tetri, David G. Parkes, Peter S. Griffin, James Napora, Carrie S. Dolman, Elizabeth M. Brunt, Jonathan D. Roth, Mary Erickson, James L. Trevaskis, Carrie Wittmer
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 302:G762-G772
These preclinical studies aimed to 1) increase our understanding the dietary induction of nonalcoholic steatohepatitis (NASH), and, 2) further explore the utility and mechanisms of glucagon-like peptide-1 receptor (GLP-1R) agonism in NASH. We compare
Autor:
Yu Zhao, James L. Trevaskis, James M. Reynolds, Peter S. Griffin, Carrie Wittmer, David G. Parkes, J K Wilson, Victoria F. Turek, Christine M. Mack, Jonathan D. Roth
Publikováno v:
Endocrinology. 151:5657-5668
In rodents, ovariectomy (OVX) elicits weight gain and diminished responsiveness to homeostatic signals. Here we characterized the response of obese OVX rats to peripheral amylin. Rats received sham surgery (SHAM), OVX, or OVX with hormonal replacemen
Autor:
N. Iqbal, E.J. Klein, Ming Zhou, Jaret Malloy, K Hollstein, Robert R. Henry, Peter S. Griffin
Publikováno v:
Diabetologie und Stoffwechsel. 10
Autor:
David G. Parkes, James L. Trevaskis, Peter S. Griffin, Jonathan D. Roth, Carrie Wittmer, Victoria F. Turek
Publikováno v:
Physiologybehavior. 100(2)
Cholecystokinin (CCK) acutely synergizes with amylin to suppress food intake in lean mice. To extend on these findings, the present studies sought to identify neural correlates for the interaction of amylin and CCK, as well as further understand the
Autor:
Victoria F. Turek, David G. Parkes, Barry E. Levin, Calvin Vu, Peter S. Griffin, Ambrose A. Dunn-Meynell, James L. Trevaskis, Boman G. Irani, Jonathan D. Roth, Carrie Wittmer, Guibao Gu
Publikováno v:
Endocrinology. 151(1)
The present studies aimed to identify mechanisms contributing to amylin/leptin synergy in reducing body weight and adiposity. We reasoned that if amylin/leptin harnessed complementary neuronal pathways, then in the leptin-sensitive state, amylin shou