Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Peter S. Gargalovic"'
Autor:
Wei Meng, Heather Finlay, Claudia Generaux, Chiuwa E. Luk, Tao Wang, Robert Paul Brigance, Joelle M. Onorato, Peter S. Gargalovic, Ruth R. Wexler, William A. Schumacher, Jeffrey S. Bostwick, Zulan Pi, Karen A. Rossi
Publikováno v:
Journal of Medicinal Chemistry. 64:18102-18113
This paper describes our continued efforts in the area of small-molecule apelin receptor agonists. Recently disclosed compound 2 showed an acceptable metabolic stability but demonstrated monodemethylation of the dimethoxyphenyl group to generate atro
Autor:
Brian J Bennett, Richard C Davis, Mete Civelek, Luz Orozco, Judy Wu, Hannah Qi, Calvin Pan, René R Sevag Packard, Eleazar Eskin, Mujing Yan, Todd Kirchgessner, Zeneng Wang, Xinmin Li, Jill C Gregory, Stanley L Hazen, Peter S Gargalovic, Aldons J Lusis
Publikováno v:
PLoS Genetics, Vol 12, Iss 3, p e1005913 (2016)
Externí odkaz:
https://doaj.org/article/523cad245e1943b2a6154791d318b64b
Autor:
Michael J. Jamieson, Wonkyung Byon, Richard W. Dettloff, Matthew Crawford, Peter S. Gargalovic, Samira J. Merali, Joelle Onorato, Andres J. Quintero, Cristina Russ
Publikováno v:
American journal of cardiovascular drugs : drugs, devices, and other interventions. 22(6)
Relatively little is known about the influence of extreme body weight on the pharmacokinetics (PK), pharmacodynamics (PD), efficacy, and safety of drugs used in many disease states. While direct oral anticoagulants (DOACs) have an advantage over warf
Autor:
Brian J Bennett, Richard C Davis, Mete Civelek, Luz Orozco, Judy Wu, Hannah Qi, Calvin Pan, René R Sevag Packard, Eleazar Eskin, Mujing Yan, Todd Kirchgessner, Zeneng Wang, Xinmin Li, Jill C Gregory, Stanley L Hazen, Peter S Gargalovic, Aldons J Lusis
Publikováno v:
PLoS Genetics, Vol 11, Iss 12, p e1005711 (2015)
Common forms of atherosclerosis involve multiple genetic and environmental factors. While human genome-wide association studies have identified numerous loci contributing to coronary artery disease and its risk factors, these studies are unable to co
Externí odkaz:
https://doaj.org/article/a6fc649140e2493cbfa62b070d41bb79
Autor:
William A. Schumacher, Yan He, Peter S. Gargalovic, Tao Wang, Joelle M. Onorato, Ruth R. Wexler, James A. Johnson, Zulan Pi, Claudia Generaux, Wei Meng, Heather Finlay, David A. Gordon, Monique Phillips, Jeffrey S. Bostwick
Publikováno v:
ACS Med Chem Lett
[Image: see text] The apelin receptor (APJ) is a significant regulator of cardiovascular function and is involved in heart failure and other cardiovascular diseases. (Pyr(1))apelin-13 is one of the endogenous agonists of the APJ receptor. Administrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c497839aa78ba246784ea2c27101a0c
https://europepmc.org/articles/PMC8591725/
https://europepmc.org/articles/PMC8591725/
Autor:
Simon T Hui, Brian W Parks, Elin Org, Frode Norheim, Nam Che, Calvin Pan, Lawrence W Castellani, Sarada Charugundla, Darwin L Dirks, Nikolaos Psychogios, Isaac Neuhaus, Robert E Gerszten, Todd Kirchgessner, Peter S Gargalovic, Aldons J Lusis
Publikováno v:
eLife, Vol 4 (2015)
To identify genetic and environmental factors contributing to the pathogenesis of non-alcoholic fatty liver disease, we examined liver steatosis and related clinical and molecular traits in more than 100 unique inbred mouse strains, which were fed a
Externí odkaz:
https://doaj.org/article/5f9ce024631843678500e7d03cc8bbb4
Autor:
Ruth R. Wexler, George O. Tora, Michael Galella, Peter S. Gargalovic, Chiuwa E. Luk, Tao Wang, Claudia Generaux, Joelle M. Onorato, Heather Finlay, Ji Jiang, Carrie Xu, Yan He, Jeffrey S. Bostwick
Publikováno v:
Bioorganicmedicinal chemistry letters. 50
Heart failure (HF) treatment remains a critical unmet medical need. Studies in normal healthy volunteers and HF patients have shown that [Pyr1]apelin-13, the endogenous ligand for the APJ receptor, improves cardiac function. However, the short half-l
Autor:
Claudia Generaux, Heather Finlay, Susan R. Arthur, Mei-Yin Hsu, Roy Haskell, Peter S. Gargalovic, Joelle M. Onorato, Michael Basso, Rongan Zhang, Kimberley A. Lentz, Anne Rose, Carrie Xu, Lei Zhao, Jeffrey S. Bostwick, Gayani Fernando, Ricardo Garcia, Xue-Qing Chen, James Hennan, Michael C. Myers, R. Michael Lawrence, Petia Shipkova, Samuel Hellings
Publikováno v:
Analytical Biochemistry. 568:41-50
Apelin, the endogenous ligand for the APJ receptor, has generated interest due to its beneficial effects on the cardiovascular system. Synthesized as a 77 amino acid preproprotein, apelin is post-translationally cleaved to a series of shorter peptide
Autor:
Ricardo A Garcia, Mujing Yan, Debra Search, Rongan Zhang, Nancy L Carson, Carol S Ryan, Constance Smith-Monroy, Joanna Zheng, Jian Chen, Yan Kong, Huaping Tang, Samuel E Hellings, Judith Wardwell-Swanson, Joseph E Dinchuk, George C Psaltis, David A Gordon, Peter W Glunz, Peter S Gargalovic
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111385 (2014)
BACKGROUND: P2Y(6), a purinergic receptor for UDP, is enriched in atherosclerotic lesions and is implicated in pro-inflammatory responses of key vascular cell types and macrophages. Evidence for its involvement in atherogenesis, however, has been lac
Externí odkaz:
https://doaj.org/article/226e843b35fe4bc7b87247e99442f01e
Autor:
Heather Finlay, Claudia Generaux, Carrie Xu, Chiuwa E. Luk, Ruth R. Wexler, Ji Jiang, James A. Johnson, Michael Galella, Jeffrey S. Bostwick, William A. Schumacher, Tao Wang, Monique Phillips, Soong-Hoon Kim, Yan He, Joelle M. Onorato, Peter S. Gargalovic, Xue-Qing Chen, David A. Gordon
Publikováno v:
Journal of medicinal chemistry. 64(6)
Apelin-13 is an endogenous peptidic agonist of the apelin receptor (APJ) receptor with the potential for improving cardiac function in heart failure patients. However, the low plasma stability of apelin-13 necessitates continuous intravenous infusion