Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Peter S. Friedmann"'
Autor:
Sofia Sirvent, Andres F. Vallejo, Emma Corden, Ying Teo, James Davies, Kalum Clayton, Eleanor G. Seaby, Chester Lai, Sarah Ennis, Rfeef Alyami, Gemma Douilhet, Lareb S. N. Dean, Matthew Loxham, Sarah Horswill, Eugene Healy, Graham Roberts, Nigel J. Hall, Peter S. Friedmann, Harinder Singh, Clare L. Bennett, Michael R Ardern-Jones, Marta E. Polak
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Regulation of cutaneous immunity is severely compromised in inflammatory skin disease. To investigate the molecular crosstalk underpinning tolerance versus inflammation in atopic dermatitis, we utilise a human in vivo allergen challenge stud
Externí odkaz:
https://doaj.org/article/8a9e3b6f395949309fb497cf8ddaabc0
Autor:
Sofia Sirvent, Andres F. Vallejo, James Davies, Kalum Clayton, Zhiguo Wu, Jeongmin Woo, Jeremy Riddell, Virendra K. Chaudhri, Patrick Stumpf, Liliya Angelova Nazlamova, Gabrielle Wheway, Matthew Rose-Zerilli, Jonathan West, Mario Pujato, Xiaoting Chen, Christopher H. Woelk, Ben MacArthur, Michael Ardern-Jones, Peter S. Friedmann, Matthew T. Weirauch, Harinder Singh, Marta E. Polak
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Langerhans cells (LC) can prime tolerogenic as well as immunogenic responses in the skin. Here the authors show, by transcriptomic, epigenetic and CRISPR editing analyses, that during LC migration and maturation the transcription factor IRF4 regulate
Externí odkaz:
https://doaj.org/article/b437083920e842f086e6d17c31b3b048
Autor:
Adrian von Witzleben, Eve Currall, Oliver Wood, Lindsey Chudley, Oluyemisi Akinyegun, Jaya Thomas, Kaïdre Bendjama, Gareth J. Thomas, Peter S. Friedmann, Emma V. King, Simon Laban, Christian H. Ottensmeier
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
IntroductionHuman papillomavirus 16 (HPV16) is the main cause of oropharyngeal squamous cell carcinoma (OPSCC). To date, the links between HPV16 gene expression and adaptive immune responses have not been investigated. We evaluated the correlation of
Externí odkaz:
https://doaj.org/article/8c0f3f22a4e94e7284de91bdb15a28b1
Autor:
Peter S. Friedmann, Kalum Clayton, Rfeef Alyami, Clare L. Bennett, James Davies, Emma Corden, Marta E Polak, Sarah Ennis, Sarah Horswill, Lareb S. N. Dean, Sofia Sirvent, Michael R. Ardern-Jones, Ying Teo, Harinder Singh, Nigel J. Hall, Chester Lai, Eleanor G. Seaby, Andres F. Vallejo, Eugene Healy, Matthew Loxham, Graham Roberts
Accurate regulation of cutaneous immunity is fundamental for human health and quality of life but is severely compromised in inflammatory skin disease. To investigate the molecular crosstalk underpinning tolerance vs inflammation in human skin, we se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ec72585e094bcb1866edfa427e11d51
https://doi.org/10.1101/2021.10.07.21264714
https://doi.org/10.1101/2021.10.07.21264714
Autor:
Neil H. Shear, Antonino Romano, Anca Mirela Chiriac, Matthew R. Nelson, Peter S. Friedmann, Alla Nakonechna, Rocco Luigi Valluzzi, S. Barrett, Jose A. Cornejo-Garcia, Miguel Blanca, Paola Nicoletti, Munir Pirmohamed, Daniel F. Carr, Pascal Demoly, Aris Floratos, Yufeng Shen, Natalia Blanca-López, Elizabeth J. Phillips, Cristiano Caruso, Laurence McEvoy, Francesco Gaeta, María José Torres, Rebecca Pavlos
Publikováno v:
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology, Elsevier, 2021, 147 (5), pp.1830-1837.e15. ⟨10.1016/j.jaci.2020.10.004⟩
The Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology, Elsevier, 2021, 147 (5), pp.1830-1837.e15. ⟨10.1016/j.jaci.2020.10.004⟩
The Journal of Allergy and Clinical Immunology
International audience; Background: β-lactam antibiotics are associated with a variety of immune-mediated or hypersensitivity reactions, including immediate (type I) reactions mediated by antigen-specific IgE.Objective: We sought to identify genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bbad6ff1f4d855de23efc3ba5043e89
https://hal.umontpellier.fr/hal-03332301/document
https://hal.umontpellier.fr/hal-03332301/document
Autor:
Ferhat Ay, Serena J Chee, Sourya Bhattacharyya, Tilman Sanchez-Elsner, Edwin Woo, Katy J. McCann, Christopher J. Hanley, Christian H. Ottensmeier, Anusha-Preethi Ganesan, Emma King, Aiman Alzetani, Simon Eschweiler, Ravindra Gujar, Bharat Panwar, Oliver Wood, Peter S Friedmann, Gareth J. Thomas, James Clarke, Pandurangan Vijayanand, Ariel Madrigal, Amiera S Awad, Grégory Seumois, Divya Singh
Publikováno v:
The Journal of Experimental Medicine
Clarke et al. interrogate human TRM cells from cancer and nonmalignant tissue. These analyses highlight that PD-1 expression in tumor-infiltrating TRM cells was positively correlated with features suggestive of active proliferation and superior funct
Autor:
Christian H. Ottensmeier, Jo Tod, Julian Taylor, Oliver Wood, Lulu Tanno, Maria Antonette Lopez, Serena J Chee, Judith Cave, Maria Machado, Margaret Ashton-Key, Peter S. Friedmann, Jonathan Dunbar, Gareth J. Thomas, Salma Naheed, Neil W. Pearce, Bryan Green
Publikováno v:
Neuroendocrinology. 112(4)
Introduction: Neuroendocrine tumours (NETs) are rare tumours with an increasing incidence. While low- and intermediate-grade pancreatic NET (PanNET) and small intestinal NET (siNET) are slow growing, they have a relatively high rate of metastasizing
Autor:
Ying X Teo, Andres F. Vallejo, Michael R. Ardern-Jones, Jeongmin Woo, Wei Yann Haw, Peter S. Friedmann, Carolann McGuire, Marta E Polak
BackgroundOne of the most severe forms of T cell mediated cutaneous adverse drug reactions is ‘drug reaction with eosinophilia and systemic symptoms’ (DRESS), hence subsequent avoidance of the causal drug is imperative. However, attribution of dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b42e5b95f23605c41a728a6fd9459b5f
https://doi.org/10.1101/2021.02.16.21250166
https://doi.org/10.1101/2021.02.16.21250166
Autor:
Christian H. Ottensmeier, Catherine C. Hedrick, Serena J Chee, Anusha-Preethi Ganesan, Tilman Sanchez-Elsner, Eva M. Garrido-Martin, Pandurangan Vijayanand, Emma King, Angelica Cazaly, Oliver Wood, Toby Mellows, James Clarke, Peter S. Friedmann, Gareth J. Thomas, Aiman Alzetani, Grégory Seumois
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
BackgroundThe role of tumor-associated macrophages (TAMs) in determining the outcome between the antitumor effects of the adaptive immune system and the tumor’s anti-immunity stratagems, is controversial. Macrophages modulate their activities and p
Autor:
Eva M, Garrido-Martin, Toby W P, Mellows, James, Clarke, Anusha-Preethi, Ganesan, Oliver, Wood, Angelica, Cazaly, Gregory, Seumois, Serena J, Chee, Aiman, Alzetani, Emma V, King, Catherine C, Hedrick, Gareth, Thomas, Peter S, Friedmann, Christian Hermann, Ottensmeier, Pandurangan, Vijayanand, Tilman, Sanchez-Elsner
Publikováno v:
Journal for Immunotherapy of Cancer
Background The role of tumor-associated macrophages (TAMs) in determining the outcome between the antitumor effects of the adaptive immune system and the tumor’s anti-immunity stratagems, is controversial. Macrophages modulate their activities and