Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Peter S. Dennis"'
Autor:
Tomasz Sewastianik, Maria Luisa Guerrera, Keith Adler, Peter S. Dennis, Kyle Wright, Vignesh Shanmugam, Ying Huang, Helen Tanton, Meng Jiang, Amanda Kofides, Maria G. Demos, Audrey Dalgarno, Neil A. Patel, Anwesha Nag, Geraldine S. Pinkus, Guang Yang, Zachary R. Hunter, Petr Jarolim, Nikhil C. Munshi, Steven P. Treon, Ruben D. Carrasco
Publikováno v:
Blood Advances, Vol 3, Iss 21, Pp 3360-3374 (2019)
Abstract: MYD88 L265P is the most common mutation in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM) and one of the most frequent in poor-prognosis subtypes of diffuse large B-cell lymphoma (DLBCL). Although inhibition of the mutat
Externí odkaz:
https://doaj.org/article/884778ec503e4d428f0f66c1a4c6dd12
Autor:
Tomasz Sewastianik, Meng Jiang, Kumar Sukhdeo, Sanjay S. Patel, Kathryn Roberts, Yue Kang, Ahmad Alduaij, Peter S. Dennis, Brian Lawney, Ruiyang Liu, Zeyuan Song, Jessie Xiong, Yunyu Zhang, Madeleine E. Lemieux, Geraldine S. Pinkus, Jeremy N. Rich, David M. Weinstock, Charles G. Mullighan, Norman E. Sharpless, Ruben D. Carrasco
Publikováno v:
Blood Advances, Vol 1, Iss 25, Pp 2361-2374 (2017)
Abstract: Despite recent advances in treatment, human precursor B-cell acute lymphoblastic leukemia (B-ALL) remains a challenging clinical entity. Recent genome-wide studies have uncovered frequent genetic alterations involving RAS pathway mutations
Externí odkaz:
https://doaj.org/article/0bffaf03598f493abbda75d7dff75772
Autor:
Irene M. Ghobrial, Vignesh Shanmugam, Juerg R. Straubhaar, Tomasz Sewastianik, Petr Jarolim, Mehmet Kemal Samur, Peter S. Dennis, Nikhil C. Munshi, Ruben D. Carrasco, Vinodh Pillai, Mary L. Bouxsein, David M. Dorfman, Jianjun Zhao, Jianli Wang, Helen Tanton, Jianhong Lin, Geraldine S. Pinkus, Daniel J. Brooks, Omar Nadeem, Ying Huang, Davide F. Robbiani, Bogdan Budnik, Meng Jiang, Keith Adler, Kenneth C. Anderson
Publikováno v:
Blood
Chromosome 13q deletion [del(13q)], harboring the miR-15a/16-1 cluster, is one of the most common genetic alterations in mature B-cell malignancies, which originate from germinal center (GC) and post-GC B cells. Moreover, miR-15a/16 expression is fre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9af4e9d01b7dc0db27575d81e956889
https://doi.org/10.1182/blood.2020009088
https://doi.org/10.1182/blood.2020009088
Autor:
Ruben D. Carrasco, Vignesh Shanmugam, Maria Demos, Maria Luisa Guerrera, Steven P. Treon, Audrey Dalgarno, Neil A. Patel, Amanda Kofides, Kyle Wright, Guang Yang, Helen Tanton, Tomasz Sewastianik, Meng Jiang, Zachary R. Hunter, Geraldine S. Pinkus, Petr Jarolim, Anwesha Nag, Peter S. Dennis, Nikhil C. Munshi, Ying Huang, Keith Adler
Publikováno v:
Blood Advances. 3:3360-3374
MYD88 L265P is the most common mutation in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM) and one of the most frequent in poor-prognosis subtypes of diffuse large B-cell lymphoma (DLBCL). Although inhibition of the mutated MYD88 p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb02bd334fed7de86d259f6fb8cc4fd2
https://doi.org/10.1182/bloodadvances.2019000588
https://doi.org/10.1182/bloodadvances.2019000588
Autor:
Ying Huang, Meng Jiang, Peter S. Dennis, Runsheng Chen, Keith Alder, Yu Xin, Ruben D. Carrasco, Ruiyang Liu, Helen Tanton, Amitabh Srivastava, Mengyun Zhang, Massimo Loda, Tomasz Sewastianik, Yue Kang, Jiao Wang, Ming Liu, Zhongqiu Wang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
Colorectal cancer (CRC) is the third most commonly diagnosed cancer, which despite recent advances in treatment, remains incurable due to molecular heterogeneity of tumor cells. The B-cell lymphoma 9 (BCL9) oncogene functions as a transcriptional co-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc12fda6f5787a87aac976d30cc8cc0
https://doi.org/10.1038/s41467-019-13842-7
https://doi.org/10.1038/s41467-019-13842-7
Autor:
Jessie Xiong, Brian Lawney, Sanjay S. Patel, David M. Weinstock, Charles G. Mullighan, Peter S. Dennis, Zeyuan Song, Ruiyang Liu, Madeleine E. Lemieux, Ahmad Alduaij, Ruben D. Carrasco, Meng Jiang, Kumar Sukhdeo, Yunyu Zhang, Norman E. Sharpless, Kathryn G. Roberts, Geraldine S. Pinkus, Tomasz Sewastianik, Yue Kang, Jeremy N. Rich
Publikováno v:
Blood Advances. 1:2361-2374
Despite recent advances in treatment, human precursor B-cell acute lymphoblastic leukemia (B-ALL) remains a challenging clinical entity. Recent genome-wide studies have uncovered frequent genetic alterations involving RAS pathway mutations and loss o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9176b2b81b61d853ad6b51d944039867
https://doi.org/10.1182/bloodadvances.2017012211
https://doi.org/10.1182/bloodadvances.2017012211
Autor:
Alex K. Shalek, Peter S. Dennis, Kristen E. Stevenson, Andrew W. Navia, Peter S. Winter, Mahnoor Mirza, Haley Strouf, Nolawit Mulugeta, Nicholas L. Calistri, Kay Shigemori, Nezha Senhaji, Jennyfer Galvez-Reyes, Laura L. Bilal, Mark L. Stevens, Scott R. Manalis, David M. Weinstock, Alejandro J. Gupta, Alex Van Scoyk, Foster Powers, Catharine S. Leahy, Robert J. Kimmerling, Huiyun Liu, Mark A. Murakami, Kristen L Jones
Publikováno v:
Cancer Research. 80:IA20-IA20
Targeted inhibitors of essential oncogenic kinases induce high rates of clinical response but cure few patients due to the persistence of minimal residual disease (MRD). BCR-ABL mutant leukemias are a classic example of this paradigm where patients u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a39c0cc185d741942493ae5bfa2977f
https://doi.org/10.1158/1538-7445.tumhet2020-ia20
https://doi.org/10.1158/1538-7445.tumhet2020-ia20
Autor:
Mary L. Bouxsein, Petr Jarolim, Peter S. Dennis, Kenneth C. Anderson, Tomasz Sewastianik, Jianhong Lin, Vinodh Pillai, Jianjun Zhao, Jianli Wang, Daniel J. Brooks, Meng Jiang, Davide F. Robbiani, Ruben D. Carrasco, Geraldine S. Pinkus, Irene M. Ghobrial
Publikováno v:
Blood. 128:743-743
MicroRNA (miR)-mediated gene regulation plays critical roles in B-cell development and dysregulated expression of miRs has been implicated in the pathogenesis of various types of B-cell malignancies. Somatic deletions of chromosome 13q14, harboring m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9a3cfee54b0a05213375ae8ef1007de
https://doi.org/10.1182/blood.v128.22.743.743
https://doi.org/10.1182/blood.v128.22.743.743
Autor:
Kwok K. Wong, Jianjun Zhao, Meng Jiang, Myles Brown, Ruben D. Carrasco, Peter S. Dennis, Tomasz Sewastianik
Publikováno v:
Blood. 128:441-441
Dysregulation of the Wnt signaling pathway underlies the pathogenesis of a wide range of human cancers, including hematological malignancies such as multiple myeloma (MM). The terminal effector of this signaling pathway is a transcriptional complex f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1229b219cf34a128f8d0563e855de191
https://doi.org/10.1182/blood.v128.22.441.441
https://doi.org/10.1182/blood.v128.22.441.441