Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Peter S. Cunningham"'
Autor:
Peter S. Cunningham, Gareth B. Kitchen, Callum Jackson, Stavros Papachristos, Thomas Springthorpe, David van Dellen, Julie Gibbs, Timothy W. Felton, Anthony J. Wilson, Jonathan Bannard-Smith, Martin K. Rutter, Thomas House, Paul Dark, Titus Augustine, Ozgur E. Akman, Andrew L. Hazel, John F. Blaikley
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 4 (2023)
Background Assessing circadian rhythmicity from infrequently sampled data is challenging; however, these types of data are often encountered when measuring circadian transcripts in hospitalized patients.Methods We present ClinCirc. This method combin
Externí odkaz:
https://doaj.org/article/db8cfa4c021e4b49aecacbf1e0167777
Autor:
Ann Louise Hunter, Charlotte E Pelekanou, Nichola J Barron, Rebecca C Northeast, Magdalena Grudzien, Antony D Adamson, Polly Downton, Thomas Cornfield, Peter S Cunningham, Jean-Noel Billaud, Leanne Hodson, Andrew SI Loudon, Richard D Unwin, Mudassar Iqbal, David W Ray, David A Bechtold
Publikováno v:
eLife, Vol 10 (2021)
The circadian clock component NR1D1 (REVERBα) is considered a dominant regulator of lipid metabolism, with global Nr1d1 deletion driving dysregulation of white adipose tissue (WAT) lipogenesis and obesity. However, a similar phenotype is not observe
Externí odkaz:
https://doaj.org/article/ea65ba8216cf4fc8be509f4be399aaf8
Autor:
Callum Jackson, Iain D Stewart, Tatiana Plekhanova, Peter S Cunningham, Andrew L Hazel, Bashar Al-Sheklly, Raminder Aul, Charlotte E Bolton, Trudie Chalder, James D Chalmers, Nazia Chaudhuri, Annemarie B Docherty, Gavin Donaldson, Charlotte L Edwardson, Omer Elneima, Neil J Greening, Neil A Hanley, Victoria C Harris, Ewen M Harrison, Ling-Pei Ho, Linzy Houchen-Wolloff, Luke S Howard, Caroline J Jolley, Mark G Jones, Olivia C Leavy, Keir E Lewis, Nazir I Lone, Michael Marks, Hamish J C McAuley, Melitta A McNarry, Brijesh V Patel, Karen Piper-Hanley, Krisnah Poinasamy, Betty Raman, Matthew Richardson, Pilar Rivera-Ortega, Sarah L Rowland-Jones, Alex V Rowlands, Ruth M Saunders, Janet T Scott, Marco Sereno, Ajay M Shah, Aarti Shikotra, Amisha Singapuri, Stefan C Stanel, Mathew Thorpe, Daniel G Wootton, Thomas Yates, R Gisli Jenkins, Sally J Singh, William D-C Man, Christopher E Brightling, Louise V Wain, Joanna C Porter, A A Roger Thompson, Alex Horsley, Philip L Molyneaux, Rachael A Evans, Samuel E Jones, Martin K Rutter, John F Blaikley, C Jackson, I D Stewart, T Plekhanova, P S Cunningham, A L Hazel, B Al-Sheklly, R Aul, C E Bolton, T Chalder, J D Chalmers, N Chaudhuri, A B Docherty, G Donaldson, C L Edwardson, O Elneima, N J Greening, N A Hanley, V C Harris, E M Harrison, L-P Ho, L Houchen-Wolloff, L S Howard, C J Jolley, M G Jones, O C Leavy, K E Lewis, N I Lone, M Marks, H J C McAuley, M A McNarry, B Patel, K Piper-Hanley, K Poinasamy, B Raman, M Richardson, P Rivera-Ortega, S L Rowland-Jones, A V Rowlands, R M Saunders, J T Scott, M Sereno, A M Shah, A Shikotra, A Singapuri, S C Stanel, M Thorpe, D G Wootton, T Yates, G Jenkins, S J Singh, W D-C Man, C E Brightling, L V Wain, J C Porter, R Thompson, A Horsley, P L Molyneaux, R A Evans, S E Jones, M K Rutter, J F Blaikley, K Abel, H Adamali, D Adeloye, O Adeyemi, R Adrego, L A Aguilar Jimenez, S Ahmad, N Ahmad Haider, R Ahmed, N Ahwireng, M Ainsworth, A Alamoudi, M Ali, M Aljaroof, AM All, L Allan, R J Allen, L Allerton, L Allsop, P Almeida, D Altmann, M Alvarez Corral, S Amoils, D Anderson, C Antoniades, G Arbane, A Arias, C Armour, L Armstrong, N Armstrong, D Arnold, H Arnold, A Ashish, A Ashworth, M Ashworth, S Aslani, H Assefa-Kebede, C Atkin, P Atkin, H Aung, L Austin, C Avram, A Ayoub, M Babores, R Baggott, J Bagshaw, D Baguley, L Bailey, J K Baillie, S Bain, M Bakali, M Bakau, E Baldry, D Baldwin, M Baldwin, C Ballard, A Banerjee, B Bang, R E Barker, L Barman, S Barratt, F Barrett, D Basire, N Basu, M Bates, A Bates, R Batterham, H Baxendale, H Bayes, M Beadsworth, P Beckett, M Beggs, M Begum, P Beirne, D Bell, R Bell, K Bennett, E Beranova, A Bermperi, A Berridge, C Berry, S Betts, E Bevan, K Bhui, M Bingham, K Birchall, L Bishop, K Bisnauthsing, J Blaikely, A Bloss, A Bolger, J Bonnington, A Botkai, C Bourne, M Bourne, K Bramham, L Brear, G Breen, J Breeze, A Briggs, E Bright, S Brill, K Brindle, L Broad, A Broadley, C Brookes, M Broome, A Brown, J Brown, J S Brown, M Brown, V Brown, T Brugha, N Brunskill, M Buch, P Buckley, A Bularga, E Bullmore, L Burden, T Burdett, D Burn, G Burns, A Burns, J Busby, R Butcher, A Butt, S Byrne, P Cairns, P C Calder, E Calvelo, H Carborn, B Card, C Carr, L Carr, G Carson, P Carter, A Casey, M Cassar, J Cavanagh, M Chablani, R C Chambers, F Chan, K M Channon, K Chapman, A Charalambou, A Checkley, J Chen, Y Cheng, L Chetham, C Childs, E R Chilvers, H Chinoy, A Chiribiri, K Chong-James, G Choudhury, N Choudhury, P Chowienczyk, C Christie, M Chrystal, D Clark, C Clark, J Clarke, S Clohisey, G Coakley, Z Coburn, S Coetzee, J Cole, C Coleman, F Conneh, D Connell, B Connolly, L Connor, A Cook, B Cooper, J Cooper, S Cooper, D Copeland, T Cosier, M Coulding, C Coupland, E Cox, T Craig, P Crisp, D Cristiano, M G Crooks, A Cross, I Cruz, P Cullinan, D Cuthbertson, L Daines, M Dalton, P Daly, A Daniels, P Dark, J Dasgin, A David, C David, E Davies, F Davies, G Davies, G A Davies, K Davies, M J Davies, J Dawson, E Daynes, A De Soyza, B Deakin, A Deans, C Deas, J Deery, S Defres, A Dell, K Dempsey, E Denneny, J Dennis, A Dewar, R Dharmagunawardena, N Diar-Bakerly, C Dickens, A Dipper, S Diver, S N Diwanji, M Dixon, R Djukanovic, H Dobson, S L Dobson, A Donaldson, T Dong, N Dormand, A Dougherty, R Dowling, S Drain, K Draxlbauer, K Drury, P Dulawan, A Dunleavy, S Dunn, C Dupont, J Earley, N Easom, C Echevarria, S Edwards, C Edwardson, H El-Taweel, A Elliott, K Elliott, Y Ellis, A Elmer, D Evans, H Evans, J Evans, R Evans, R I Evans, T Evans, C Evenden, L Evison, L Fabbri, S Fairbairn, A Fairman, K Fallon, D Faluyi, C Favager, T Fayzan, J Featherstone, T Felton, J Finch, S Finney, J Finnigan, L Finnigan, H Fisher, S Fletcher, R Flockton, M Flynn, H Foot, D Foote, A Ford, D Forton, E Fraile, C Francis, R Francis, S Francis, A Frankel, E Fraser, R Free, N French, X Fu, J Fuld, J Furniss, L Garner, N Gautam, J R Geddes, J George, P M George, M Gibbons, M Gill, L Gilmour, F Gleeson, J Glossop, S Glover, N Goodman, C Goodwin, B Gooptu, H Gordon, T Gorsuch, M Greatorex, P L Greenhaff, W Greenhalf, A Greenhalgh, J Greenwood, H Gregory, R Gregory, D Grieve, D Griffin, L Griffiths, A-M Guerdette, B Guillen Guio, M Gummadi, A Gupta, S Gurram, E Guthrie, Z Guy, H Henson, K Hadley, A Haggar, K Hainey, B Hairsine, P Haldar, I Hall, L Hall, M Halling-Brown, R Hamil, A Hancock, K Hancock, S Haq, H E Hardwick, E Hardy, T Hardy, B Hargadon, K Harrington, E Harris, P Harrison, N Hart, A Harvey, M Harvey, M Harvie, L Haslam, M Havinden-Williams, J Hawkes, N Hawkings, J Haworth, A Hayday, M Haynes, J Hazeldine, T Hazelton, L G Heaney, C Heeley, J L Heeney, M Heightman, S Heller, M Henderson, L Hesselden, M Hewitt, V Highett, T Hillman, T Hiwot, A Hoare, M Hoare, J Hockridge, P Hogarth, A Holbourn, S Holden, L Holdsworth, D Holgate, M Holland, L Holloway, K Holmes, M Holmes, B Holroyd-Hind, L Holt, A Hormis, A Hosseini, M Hotopf, K Howard, A Howell, E Hufton, A D Hughes, J Hughes, R Hughes, A Humphries, N Huneke, E Hurditch, J Hurst, M Husain, T Hussell, J Hutchinson, W Ibrahim, F Ilyas, J Ingham, L Ingram, D Ionita, K Isaacs, K Ismail, T Jackson, J Jacob, W Y James, W Jang, C Jarman, I Jarrold, H Jarvis, R Jastrub, B Jayaraman, R G Jenkins, P Jezzard, K Jiwa, C Johnson, S Johnson, D Johnston, D Jones, G Jones, H Jones, I Jones, L Jones, S Jones, S Jose, T Kabir, G Kaltsakas, V Kamwa, N Kanellakis, S Kaprowska, Z Kausar, N Keenan, S Kelly, G Kemp, S Kerr, H Kerslake, A L Key, F Khan, K Khunti, S Kilroy, B King, C King, L Kingham, J Kirk, P Kitterick, P Klenerman, L Knibbs, S Knight, A Knighton, O Kon, S Kon, S S Kon, S Koprowska, A Korszun, I Koychev, C Kurasz, P Kurupati, C Laing, H Lamlum, G Landers, C Langenberg, D Lasserson, L Lavelle-Langham, A Lawrie, C Lawson, A Layton, A Lea, D Lee, J-H Lee, E Lee, K Leitch, R Lenagh, D Lewis, J Lewis, V Lewis, N Lewis-Burke, X Li, T Light, L Lightstone, W Lilaonitkul, L Lim, S Linford, A Lingford-Hughes, M Lipman, K Liyanage, A Lloyd, S Logan, D Lomas, R Loosley, J M Lord, H Lota, W Lovegrove, A Lucey, E Lukaschuk, A Lye, C Lynch, S MacDonald, G MacGowan, I Macharia, J Mackie, L Macliver, S Madathil, G Madzamba, N Magee, M M Magtoto, N Mairs, N Majeed, E Major, F Malein, M Malim, G Mallison, S Mandal, K Mangion, C Manisty, R Manley, K March, S Marciniak, P Marino, M Mariveles, E Marouzet, S Marsh, B Marshall, M Marshall, J Martin, A Martineau, L M Martinez, N Maskell, D Matila, W Matimba-Mupaya, L Matthews, A Mbuyisa, S McAdoo, H McAllister-Williams, A McArdle, P McArdle, D McAulay, G P McCann, J McCormick, W McCormick, P McCourt, L McGarvey, C McGhee, K Mcgee, J McGinness, K McGlynn, A McGovern, H McGuinness, I B McInnes, J McIntosh, E McIvor, K McIvor, L McLeavey, A McMahon, M J McMahon, L McMorrow, T Mcnally, M McNarry, J McNeill, A McQueen, H McShane, C Mears, C Megson, S Megson, P Mehta, J Meiring, L Melling, M Mencias, D Menzies, M Merida Morillas, A Michael, C Miller, L Milligan, C Mills, G Mills, N L Mills, L Milner, S Misra, J Mitchell, A Mohamed, N Mohamed, S Mohammed, W Monteiro, S Moriera, A Morley, L Morrison, R Morriss, A Morrow, A J Moss, P Moss, K Motohashi, N Msimanga, E Mukaetova-Ladinska, U Munawar, J Murira, U Nanda, H Nassa, M Nasseri, A Neal, R Needham, P Neill, S Neubauer, D E Newby, H Newell, T Newman, J Newman, A Newton-Cox, T Nicholson, D Nicoll, A Nikolaidis, C M Nolan, M J Noonan, C Norman, P Novotny, J Nunag, L Nwafor, U Nwanguma, J Nyaboko, C O'Brien, K O'Donnell, D O'Regan, L O'Brien, N Odell, G Ogg, O Olaosebikan, C Oliver, Z Omar, P J M Openshaw, L Orriss-Dib, L Osborne, R Osbourne, M Ostermann, C Overton, J Owen, J Oxton, J Pack, E Pacpaco, S Paddick, S Painter, A Pakzad, S Palmer, P Papineni, K Paques, K Paradowski, M Pareek, D Parekh, H Parfrey, C Pariante, S Parker, M Parkes, J Parmar, S Patale, M Patel, S Patel, D Pattenadk, M Pavlides, S Payne, L Pearce, J E Pearl, D Peckham, J Pendlebury, Y Peng, C Pennington, I Peralta, E Perkins, Z Peterkin, T Peto, N Petousi, J Petrie, P Pfeffer, J Phipps, J Pimm, R Pius, H Plant, S Plein, M Plowright, O Polgar, L Poll, J Porter, S Portukhay, N Powell, A Prabhu, J Pratt, A Price, C Price, D Price, L Price, A Prickett, J Propescu, S Prosper, S Pugmire, S Quaid, J Quigley, J Quint, H Qureshi, I N Qureshi, K Radhakrishnan, N M Rahman, M Ralser, A Ramos, H Ramos, J Rangeley, B Rangelov, L Ratcliffe, P Ravencroft, A Reddington, R Reddy, A Reddy, H Redfearn, D Redwood, A Reed, M Rees, T Rees, K Regan, W Reynolds, C Ribeiro, A Richards, E Richardson, K Roberts, E Robertson, E Robinson, L Robinson, L Roche, C Roddis, J Rodger, A Ross, G Ross, J Rossdale, A Rostron, A Rowe, A Rowland, J Rowland, M J Rowland, K Roy, M Roy, I Rudan, R Russell, E Russell, G Saalmink, R Sabit, E K Sage, T Samakomva, N Samani, C Sampson, K Samuel, R Samuel, A Sanderson, E Sapey, D Saralaya, J Sargent, C Sarginson, T Sass, N Sattar, K Saunders, P Saunders, L C Saunders, H Savill, W Saxon, A Sayer, J Schronce, W Schwaeble, K Scott, N Selby, M G Semple, T A Sewell, K Shah, P Shah, M Shankar-Hari, M Sharma, C Sharpe, M Sharpe, S Shashaa, A Shaw, K Shaw, V Shaw, A Sheikh, S Shelton, L Shenton, K Shevket, J Short, S Siddique, S Siddiqui, J Sidebottom, L Sigfrid, G Simons, J Simpson, N Simpson, C Singh, D Sissons, J Skeemer, K Slack, A Smith, D Smith, S Smith, J Smith, L Smith, M Soares, T S Solano, R Solly, A R Solstice, T Soulsby, D Southern, D Sowter, M Spears, L G Spencer, F Speranza, L Stadon, S Stanel, N Steele, M Steiner, D Stensel, G Stephens, L Stephenson, M Stern, R Stimpson, S Stockdale, J Stockley, W Stoker, R Stone, W Storrar, A Storrie, K Storton, E Stringer, S Strong-Sheldrake, N Stroud, C Subbe, C L Sudlow, Z Suleiman, C Summers, C Summersgill, D Sutherland, D L Sykes, R Sykes, N Talbot, A L Tan, L Tarusan, V Tavoukjian, A Taylor, C Taylor, J Taylor, A Te, H Tedd, C J Tee, J Teixeira, H Tench, S Terry, S Thackray-Nocera, F Thaivalappil, B Thamu, D Thickett, C Thomas, D C Thomas, S Thomas, A K Thomas, T Thomas-Woods, T Thompson, A A R Thompson, T Thornton, R S Thwaites, J Tilley, N Tinker, G F Tiongson, M Tobin, J Tomlinson, C Tong, M Toshner, R Touyz, K A Tripp, E Tunnicliffe, A Turnbull, E Turner, S Turner, V Turner, K Turner, S Turney, L Turtle, H Turton, J Ugoji, R Ugwuoke, R Upthegrove, J Valabhji, M Ventura, J Vere, C Vickers, B Vinson, E Wade, P Wade, T Wainwright, L O Wajero, S Walder, S Walker, E Wall, T Wallis, S Walmsley, J A Walsh, S Walsh, L Warburton, T J C Ward, K Warwick, H Wassall, S Waterson, E Watson, L Watson, J Watson, J Weir McCall, C Welch, H Welch, B Welsh, S Wessely, S West, H Weston, H Wheeler, S White, V Whitehead, J Whitney, S Whittaker, B Whittam, V Whitworth, A Wight, J M Wild, M Wilkins, D Wilkinson, B Williams, N Williams, J Williams, S A Williams-Howard, M Willicombe, G Willis, J Willoughby, A Wilson, D Wilson, I Wilson, N Window, M Witham, R Wolf-Roberts, C Wood, F Woodhead, J Woods, J Wormleighton, J Worsley, D Wraith, C Wrey Brown, C Wright, L Wright, S Wright, J Wyles, I Wynter, M Xu, N Yasmin, S Yasmin, K P Yip, B Young, S Young, A Young, A J Yousuf, A Zawia, L Zeidan, B Zhao, B Zheng, O Zongo
Publikováno v:
Jackson, C, Stewart, I D, Plekhanova, T, Cunningham, P S, Hazel, A L, Al-Sheklly, B, Aul, R, Bolton, C E, Chalder, T, Chalmers, J D, Chaudhuri, N, Docherty, A B, Donaldson, G, Edwardson, C L, Elneima, O, Greening, N J, Hanley, N A, Harris, V C, Harrison, E M, Ho, L-P, Houchen-Wolloff, L, Howard, L S, Jolley, C J, Jones, M G, Leavy, O C, Lewis, K E, Lone, N I, Marks, M, McAuley, H J C, McNarry, M A, Patel, B V, Piper-Hanley, K, Poinasamy, K, Raman, B, Richardson, M, Rivera-Ortega, P, Rowland-Jones, S L, Rowlands, A V, Saunders, R M, Scott, J T, Sereno, M, Shah, A M, Shikotra, A, Singapuri, A, Stanel, S C, Thorpe, M, Wootton, D G, Yates, T, Gisli Jenkins, R, Singh, S J, Man, W D-C, Brightling, C E, Wain, L V, Porter, J C, Thompson, A A R, Horsley, A, Molyneaux, P L, Evans, R A, Jones, S E & Rutter, M K & Blaikley, J F 2023, ' Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK : a prospective multicentre cohort study ', The Lancet Respiratory Medicine . https://doi.org/10.1016/S2213-2600(23)00124-8
Data sharing: The PHOSP-COVID study protocol, consent form, definition, and derivation of clinical characteristics and outcomes, training materials, regulatory documents, information about requests for data access, and other relevant study materials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cf547104e6f481b06ec824eed92973b
http://hdl.handle.net/10044/1/103507
http://hdl.handle.net/10044/1/103507
Autor:
John Blaikley, Gareth B. Kitchen, Tracy Hussell, Mudassar Iqbal, Robert Maidstone, Laura Matthews, Hannah J. Durrington, Peter S. Cunningham, James Bagnall, Nicola Begley, Matthew Baxter, Ben Saer, Toryn Poolman, Julie E. Gibbs, Andrew S. I. Loudon, David W. Ray, David H. Dockrell
Publikováno v:
Kitchen, G B, Cunningham, P S, Poolman, T M, Iqbal, M, Maidstone, R, Baxter, M, Bagnall, J, Begley, N, Saer, B, Hussell, T, Matthews, L C, Dockrell, D H, Durrington, H J, Gibbs, J E, Blaikley, J F, Loudon, A S & Ray, D W 2020, ' The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia ', Proceedings of the National Academy of Sciences, vol. 117, no. 3, pp. 1543-1551 . https://doi.org/10.1073/pnas.1915932117
The circadian clock regulates many aspects of immunity. Bacterial infections are affected by time of day, but the mechanisms involved remain undefined. Here we show that loss of the core clock protein BMAL1 in macrophages confers protection against p
Autor:
John Blaikley, Andrew S. I. Loudon, Peter Meijer, Andrew J. Fisher, Karen Piper-Hanley, Neil C. Henderson, Alicja Nazgiewicz, Rajamayier V. Venkateswaran, Gareth B. Kitchen, Martin K. Rutter, James Bagnall, Rachel C. Chambers, Lee A. Borthwick, Boris Hinz, Nicola Begley, Peter S. Cunningham, Rajesh Shah, Julie E. Gibbs, David W. Ray, Simon G. Anderson, Monika Lodyga, Paul F. Mercer, David A. Bechtold, Hannah J. Durrington
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Cunningham, P, Meijer, P, Nazgiewicz, A, Anderson, S, Borthwick, L A, Bagnall, J, Kitchen, G, Lodyga, M, Begley, N, Venkateswaran, R, Shah, R, Mercer, P F, Durrington, H, Henderson, N, Piper Hanley, K, Fisher, A, Chambers, R C, Bechtold, D, Gibbs, J, Loudon, A, Rutter, M K, Hinz, B, Ray, D & Blaikley, J 2020, ' The circadian clock protein REVERBα inhibits pulmonary fibrosis development ', Proceedings of the National Academy of Sciences, vol. 117, no. 2, pp. 1139-1147 . https://doi.org/10.1073/pnas.1912109117
Cunningham, P S, Meijer, P, Nazgiewicz, A, Anderson, S G, Borthwick, L A, Bagnall, J, Kitchen, G B, Lodyga, M, Begley, N, Venkateswaran, R V, Shah, R, Mercer, P F, Durrington, H J, Henderson, N C, Piper-hanley, K, Fisher, A J, Chambers, R C, Bechtold, D A, Gibbs, J E, Loudon, A S, Rutter, M K, Hinz, B, Ray, D W & Blaikley, J F 2020, ' The circadian clock protein REVERBα inhibits pulmonary fibrosis development ', Proceedings of the National Academy of Sciences, vol. 117, no. 2, pp. 1139-1147 . https://doi.org/10.1073/pnas.1912109117
Cunningham, P, Meijer, P, Nazgiewicz, A, Anderson, S, Borthwick, L A, Bagnall, J, Kitchen, G, Lodyga, M, Begley, N, Venkateswaran, R, Shah, R, Mercer, P F, Durrington, H, Henderson, N, Piper Hanley, K, Fisher, A, Chambers, R C, Bechtold, D, Gibbs, J, Loudon, A, Rutter, M K, Hinz, B, Ray, D & Blaikley, J 2020, ' The circadian clock protein REVERBα inhibits pulmonary fibrosis development ', Proceedings of the National Academy of Sciences, vol. 117, no. 2, pp. 1139-1147 . https://doi.org/10.1073/pnas.1912109117
Cunningham, P S, Meijer, P, Nazgiewicz, A, Anderson, S G, Borthwick, L A, Bagnall, J, Kitchen, G B, Lodyga, M, Begley, N, Venkateswaran, R V, Shah, R, Mercer, P F, Durrington, H J, Henderson, N C, Piper-hanley, K, Fisher, A J, Chambers, R C, Bechtold, D A, Gibbs, J E, Loudon, A S, Rutter, M K, Hinz, B, Ray, D W & Blaikley, J F 2020, ' The circadian clock protein REVERBα inhibits pulmonary fibrosis development ', Proceedings of the National Academy of Sciences, vol. 117, no. 2, pp. 1139-1147 . https://doi.org/10.1073/pnas.1912109117
Significance The circadian clock plays an essential role in energy metabolism and inflammation. In contrast, the importance of the clock in the pathogenesis of fibrosis remains poorly explored. This study describes a striking alteration in circadian
Autor:
Antony Adamson, Mudassar Iqbal, Magdalena Grudzien, Andrew S. I. Loudon, Richard D. Unwin, David W. Ray, Ann Louise Hunter, Nichola J Barron, Leanne Hodson, Charlotte E Pelekanou, Rebecca C Northeast, Peter S. Cunningham, Jean-Noel Billaud, David A. Bechtold, Thomas Cornfield, Polly Downton
Publikováno v:
eLife, Vol 10 (2021)
Hunter, A L, Pelekanou, C, Barron, N, Northeast, R, Grudzien, M, Adamson, A, Downton, P, Cornfield, T, Cunningham, P, Billaud, J-N, Hodson, L, Loudon, A S I, Unwin, R, Iqbal, M, Ray, D & Bechtold, D 2021, ' Adipocyte NR1D1 dictates adipose tissue expansion during obesity ', eLife, vol. 10, e63324 . https://doi.org/10.7554/eLife.63324
eLife
Hunter, A L, Pelekanou, C, Barron, N, Northeast, R, Grudzien, M, Adamson, A, Downton, P, Cornfield, T, Cunningham, P, Billaud, J-N, Hodson, L, Loudon, A S I, Unwin, R, Iqbal, M, Ray, D & Bechtold, D 2021, ' Adipocyte NR1D1 dictates adipose tissue expansion during obesity ', eLife, vol. 10, e63324 . https://doi.org/10.7554/eLife.63324
eLife
The circadian clock component NR1D1 (REVERBα) is considered a dominant regulator of lipid metabolism, with global Nr1d1 deletion driving dysregulation of white adipose tissue (WAT) lipogenesis and obesity. However, a similar phenotype is not observe
Autor:
Ann Louise Hunter, Charlotte E Pelekanou, Nichola J Barron, Rebecca C Northeast, Magdalena Grudzien, Antony D Adamson, Polly Downton, Thomas Cornfield, Peter S Cunningham, Jean-Noel Billaud, Leanne Hodson, Andrew SI Loudon, Richard D Unwin, Mudassar Iqbal, David W Ray, David A Bechtold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75c671fe780bfcd2afa89ba7fbb1cb9b
https://doi.org/10.7554/elife.63324.sa2
https://doi.org/10.7554/elife.63324.sa2
Timekeeping in the hindbrain: a multi-oscillatory circadian centre in the mouse dorsal vagal complex
Autor:
Rebecca C Northeast, Peter S. Cunningham, Cheryl Petit, Lukasz Chrobok, Hugh D. Piggins, Jihwan Myung
Publikováno v:
Chrobok, L, Northeast, R C, Myung, J, Cunningham, P S, Petit, C & Piggins, H D 2020, ' Timekeeping in the hindbrain: a multi-oscillatory circadian centre in the mouse dorsal vagal complex ', Communications Biology, vol. 3, no. 1 . https://doi.org/10.1038/s42003-020-0960-y
Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-12 (2020)
Chrobok, L, Northeast, R C, Myung, J, Cunningham, P S, Petit, C & Piggins, H D 2020, ' Timekeeping in the hindbrain : a multi-oscillatory circadian centre in the mouse dorsal vagal complex ', Communications Biology, vol. 3, 225 (2020) . https://doi.org/10.1038/s42003-020-0960-y
Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-12 (2020)
Chrobok, L, Northeast, R C, Myung, J, Cunningham, P S, Petit, C & Piggins, H D 2020, ' Timekeeping in the hindbrain : a multi-oscillatory circadian centre in the mouse dorsal vagal complex ', Communications Biology, vol. 3, 225 (2020) . https://doi.org/10.1038/s42003-020-0960-y
Metabolic and cardiovascular processes controlled by the hindbrain exhibit 24 h rhythms, but the extent to which the hindbrain possesses endogenous circadian timekeeping is unresolved. Here we provide compelling evidence that genetic, neuronal, and v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f889cce14a00a47e3c8dc64fce4d94
https://www.research.manchester.ac.uk/portal/en/publications/timekeeping-in-the-hindbrain-a-multioscillatory-circadian-centre-in-the-mouse-dorsal-vagal-complex(78d93a1f-e40e-46d8-b579-6065d1027188).html
https://www.research.manchester.ac.uk/portal/en/publications/timekeeping-in-the-hindbrain-a-multioscillatory-circadian-centre-in-the-mouse-dorsal-vagal-complex(78d93a1f-e40e-46d8-b579-6065d1027188).html
Autor:
Antony Adamson, Neil E. Humphreys, Nichola J Barron, Andrew S. I. Loudon, Charlotte E Pelekanou, Peter S. Cunningham, Thomas Cornfield, Leanne Hodson, David A. Bechtold, Mudassar Iqbal, Toryn Poolman, A Louise Hunter, David W. Ray, Polly Downton
Publikováno v:
Hunter, A L, Pelekanou, C E, Adamson, A, Downton, P, Barron, N J, Cornfield, T, Poolman, T M, Humphreys, N, Cunningham, P S, Hodson, L, Loudon, A S I, Iqbal, M, Bechtold, D A & Ray, D W 2020, ' Nuclear receptor REVERBα is a state-dependent regulator of liver energy metabolism ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 41, pp. 25869-25879 . https://doi.org/10.1073/pnas.2005330117
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance The circadian clock protein REVERBα is proposed to be a key regulator of liver metabolism. We now show that REVERBα action is critically dependent on metabolic state. Using transgenic mouse models, we show that the true role of REVERB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b780ad5cc39a9feed1e926f5f4102604
https://doi.org/10.1073/pnas.2005330117
https://doi.org/10.1073/pnas.2005330117
Autor:
Loudon Asi., Mudassar Iqbal, Rebecca C Northeast, Peter S. Cunningham, David A. Bechtold, Polly Downton, Richard D. Unwin, Leanne Hodson, Antony Adamson, Nichola J Barron, David W. Ray, A Louise Hunter, Thomas Cornfield, Charlotte E Pelekanou
The circadian clock component REVERBα is considered a dominant regulator of lipid metabolism, with globalReverbαdeletion driving dysregulation of white adipose tissue (WAT) lipogenesis and obesity. However, a similar phenotype is not observed under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e6d52228e7f75797b2a21bbc57c3152
https://doi.org/10.1101/2020.09.23.308155
https://doi.org/10.1101/2020.09.23.308155