Výsledky vyhledávání - "Peter S Thomas"

Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAP-K2) as an Antiinflammatory Target: Discovery and in Vivo Activity of Selective Pyrazolo[1,5-a]pyrimidine Inhibitors Using a Focused Library and Structure-Based Optimization Approach

Publikováno v: Journal of Medicinal Chemistry. 55:6700-6715

A novel class of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) inhibitors was discovered through screening a kinase-focused library. A homology model of MAPKAP-K2 was generated and used to guide the initial SAR studies and t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c0728626099c0f201fdffc260a93476
https://doi.org/10.1021/jm300411k

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The synthesis and fungicidal activity of a series of 1-aryltetrazole-5-sulphones

Autor: Peter S. Thomas, Ian C. Richards

Publikováno v: Pesticide Science. 30:275-284

The synthesis and fungicidal activity of a series of l-aryltetrazole-5-sulphones are reported. Their activity against Plasmopara viticola is described. It is proposed that the compounds act as general electrophiles. Structure-activity relationships a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aefa225275f0c80ed524164b66d759ac
https://doi.org/10.1002/ps.2780300304

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Correction to Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAP-K2) as an Antiinflammatory Target: Discovery and in Vivo Activity of Selective Pyrazolo[1,5-a]pyrimidine Inhibitors Using a Focused Library and Structure-Based Optimization Approach

Publikováno v: Journal of Medicinal Chemistry. 55:10312-10313

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5fa908608094bc989344374dab7672b7
https://doi.org/10.1021/jm3013954

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Purines, pyrimidines, and imidazoles. Part 50. Inhibition of adenylosuccinate AMP-lyase no. 4.3.2.2. by derivatives of N-(5-amino-1-β-D-ribofuranosylimidazole-4-carbonyl)-L-aspartic acid 5′-phosphate (SAICAR) and virazole 5′-phosphate

Autor: Peter S. Thomas, Gordon Shaw, Susan E. Thomas, Carole Anne Hilton Patey

Publikováno v: J. Chem. Soc., Perkin Trans. 1. :1415-1424

N-(5-Amino-1-β-D-ribofuranosyl-4-carbonyl)-L-aspartic acid 5′-phosphate (SAICAR) and some related imidazole peptides have been shown to form in low yield in aqueous solution from the appropriate imidazolecarboxylic acid, an amino-acid or ester and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::731b1fcf1f653babd70013b18d96bf3e
https://doi.org/10.1039/p19790001415

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Purines, pyrimidines, and imidazoles. Part 45. Stereospecific syntheses of some 1-D-ribofuranosyl- and 1-D-xylofuranosyl-uracil derivatives

Autor: Roy Lofthouse, Grahame Mackenzie, Gordon Shaw, David H. Robinson, Peter W. Rugg, Peter S. Thomas

Publikováno v: Journal of the Chemical Society, Perkin Transactions 1. :997

Ethyl N-[α-acetyl-β-(5,6-O-isopropylidene-D-glucofuranosylamino)acryloyl]carbamate and the corresponding α-ethoxycarbonyl derivative have been prepared from 5,6-O-isopropylidene-D-glucofuranosylamine with ethyl N-(α-acetyl-β-ethoxyacryloyl)carba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f75c9d9a6ad2f0ecb87505310e17213
https://doi.org/10.1039/p19770000997

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