Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Peter S N Rowe"'
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97326 (2014)
ContextPHEX or DMP1 mutations cause hypophosphatemic-rickets and altered energy metabolism. PHEX binds to DMP1-ASARM-motif to form a complex with α5β3 integrin that suppresses FGF23 expression. ASARM-peptides increase FGF23 by disrupting the PHEX-D
Externí odkaz:
https://doaj.org/article/db94a614e0f3454eaed6351fb08f1830
Autor:
Joshua N. Curry, Koichi Matsuda, Mehdi Totonchi, Michael B. Filla, Masomeh Askari, Lei Pei, Timothy A. Fields, Chizu Tanikawa, Matthew Saurette, Andrew P. Evan, Peter S. N. Rowe, Megan R Beggs, Andre J. Sommer, Yoichiro Kamatani, Alan S.L. Yu, R. Todd Alexander
Publikováno v:
J Clin Invest
The major risk factor for kidney stone disease is idiopathic hypercalciuria. Recent evidence implicates a role for defective calcium reabsorption in the renal proximal tubule. We hypothesized that claudin-2, a paracellular cation channel protein, med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f05480511ce3875180ae5092824f7188
https://doi.org/10.1172/jci127750
https://doi.org/10.1172/jci127750
Autor:
Olivia C. Eller, Rena N. Stair, Christopher Neal, Peter S. N. Rowe, Jennifer Nelson-Brantley, Erin E. Young, Kyle M. Baumbauer
Spinal cord injury (SCI) is a complex syndrome that has profound effects on patient well-being, including the development of medically-resistant chronic pain. The mechanisms underlying SCI pain have been the subject of thorough investigation but rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72c2e2919542ea1fa3ba57670033236b
https://doi.org/10.1101/2021.06.15.448577
https://doi.org/10.1101/2021.06.15.448577
Autor:
Phil Lee, Lesya Zelenchuk, Jennifer S. Laurence, Peter S. N. Rowe, Ellen T. McCarthy, William Brooks
Publikováno v:
American Journal of Physiology-Renal Physiology. 309:F764-F769
Nephrogenic systemic fibrosis (NSF) is a devastating condition associated with gadolinium (Gd3+)-based contrast agents (GBCAs) in patients with kidney disease. The release of toxic Gd3+ from GBCAs likely plays a major role in NSF pathophysiology. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::782ff27d1204ff64387b3d600a136f0a
https://doi.org/10.1152/ajprenal.00201.2015
https://doi.org/10.1152/ajprenal.00201.2015
Publikováno v:
Bone. 79:131-142
Context Mice with null mutations in matrix extracellular phosphoglycoprotein (MEPE) have increased bone mass, increased trabecular density and abnormal cancellous bone (MN-mice). These defects worsen with age and MEPE overexpression induces opposite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03aef16ae3f09e1949582fc50d46972c
https://doi.org/10.1016/j.bone.2015.05.030
https://doi.org/10.1016/j.bone.2015.05.030
Publikováno v:
Bone. 72:23-33
Context ASARM-peptides are substrates and ligands for PHEX, the gene responsible for X-linked hypophosphatemic rickets (HYP). PHEX binds to the DMP1-ASARM-motif to form a trimeric-complex with α5β3-integrin on the osteocyte surface and this suppres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16b076b4d0edb0205577bdcee1a38c09
https://doi.org/10.1016/j.bone.2014.11.011
https://doi.org/10.1016/j.bone.2014.11.011
Autor:
Lotfi Slimani, P. Chafey, Benjamin R. Coyac, Peter S. N. Rowe, Agnès Linglart, Guillaume Falgayrac, Guillaume Penel, Marc D. McKee, Claire Bardet, Betty Hoac, Catherine Chaussain
Publikováno v:
Journal of dental research. 97(2)
X-linked hypophosphatemia (XLH) is a skeletal disease caused by inactivating mutations in the PHEX gene. Mutated or absent PHEX protein/enzyme leads to a decreased serum phosphate level, which cause mineralization defects in the skeleton and teeth (o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9306ac9b65f26fc20c06341a5231971
https://pubmed.ncbi.nlm.nih.gov/28880715
https://pubmed.ncbi.nlm.nih.gov/28880715
Autor:
Priyanka Tadikonda, Ossama Tawfik, Peter S. N. Rowe, Rama Garimella, Sumedha Gunewardena, Peter J. Van Veldhuizen
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 18; Issue 3; Pages: 642
International Journal of Molecular Sciences, Vol 18, Iss 3, p 642 (2017)
International Journal of Molecular Sciences; Volume 18; Issue 3; Pages: 642
International Journal of Molecular Sciences, Vol 18, Iss 3, p 642 (2017)
Osteosarcoma (OS) is an aggressive malignancy of bone affecting children, adolescents and young adults. Understanding vitamin D metabolism and vitamin D regulated genes in OS is an important aspect of vitamin D/cancer paradigm, and in evaluating vita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53989fecc00c480976a69b23cc2891eb
http://europepmc.org/articles/PMC5372654
http://europepmc.org/articles/PMC5372654
Autor:
Marco Brotto, Ossama Tawfik, Janalee Isaacson, Madoka Spence, Peter S. N. Rowe, Laurie Washington, Raymond P. Perez, Rama Garimella, Julian Vallejo
Publikováno v:
Translational Oncology
The bone microenvironment (BME) is the main hub of all skeletal related pathological events in osteosarcoma leading to tumor induced bone destruction, and decreasing overall bone quality and bone strength. The role of extra-cellular membrane vesicles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::861ca72bd1b0e8d2f87c8937d4981563
https://doi.org/10.1016/j.tranon.2014.04.011
https://doi.org/10.1016/j.tranon.2014.04.011
Autor:
Peter S. N. Rowe, Yan Hong, George A. Vielhauer, Jeff Eskew, Priyanka Bhamidi, Ossama Tawfik, Rama Garimella, H. Clarke Anderson
Publikováno v:
Journal of Bone Oncology
Osteosarcoma (OS) is a bone malignancy that affects children and adolescents. It is a highly aggressive tumor and typically metastasizes to lungs. Despite aggressive chemotherapy and surgical treatments, the current 5 year survival rate is 60–70%.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d570e3f284aa10299ad4339e4279c7