Zobrazeno 1 - 10
of 267
pro vyhledávání: '"Peter S Linsley"'
Autor:
Warren Anderson, Fariba Barahmand-pour-Whitman, Peter S Linsley, Karen Cerosaletti, Jane H Buckner, David J Rawlings
Publikováno v:
eLife, Vol 12 (2023)
A genetic variant in the gene PTPN22 (R620W, rs2476601) is strongly associated with increased risk for multiple autoimmune diseases and linked to altered TCR regulation and T cell activation. Here, we utilize Crispr/Cas9 gene editing with donor DNA r
Externí odkaz:
https://doaj.org/article/3e6736e42d8c4ec0adf0ff3beeb58b90
Autor:
Hannah A DeBerg, Mussaret B Zaidi, Matthew C Altman, Prasong Khaenam, Vivian H Gersuk, Freddy D Campos, Iza Perez-Martinez, Mario Meza-Segura, Damien Chaussabel, Jacques Banchereau, Teresa Estrada-Garcia, Peter S Linsley
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0192082 (2018)
Globally, diarrheal diseases are a leading cause of death in children under five and disproportionately affect children in developing countries. Children who contract diarrheal diseases are rarely screened to identify the etiologic agent due to time
Externí odkaz:
https://doaj.org/article/ec9483f875f64f2ea994a2f03298c003
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138726 (2015)
Enhancing pre-existing anti-tumor immunity leads to therapeutic benefit for some patients, but why some tumors are more immunogenic than others remains unresolved. We took a unique systems approach to relate patient survival to immune gene expression
Externí odkaz:
https://doaj.org/article/7bc302acdcc54d8f8932ab953949b4ea
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109760 (2014)
While immunotherapies are rapidly becoming mainstays of cancer treatment, significant gaps remain in our understanding of how to optimally target them, alone or in combination. Here we describe a novel method to monitor levels of immune cells and pat
Externí odkaz:
https://doaj.org/article/6cd845de85f24419ad969caf119d4695
Autor:
Daniel A Kuppers, Harry C Hwang, Aimee L Jackson, Peter S Linsley, Bruce E Clurman, Matthew L Fero
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e14758 (2011)
Mice lacking the p27(Kip1) Cdk inhibitor (Cdkn1b) exhibit increased susceptibility to lymphomas from the Maloney murine leukemia virus (M-MuLV), and exhibit a high frequency of viral integrations at Xpcl1 (Kis2), a locus on the X-chromosome. Xpcl1 en
Externí odkaz:
https://doaj.org/article/d72def821bff4b12b228cd374b202ed2
Autor:
Xudong Dai, Angus T De Souza, Hongyue Dai, David L Lewis, Chang-kyu Lee, Andy G Spencer, Hans Herweijer, Jim E Hagstrom, Peter S Linsley, Douglas E Bassett, Roger G Ulrich, Yudong D He
Publikováno v:
PLoS Computational Biology, Vol 3, Iss 3, p e30 (2007)
Uncovering pathways underlying drug-induced toxicity is a fundamental objective in the field of toxicogenomics. Developing mechanism-based toxicity biomarkers requires the identification of such novel pathways and the order of their sufficiency in ca
Externí odkaz:
https://doaj.org/article/4bbedddb2b9044bea8ea3ca7ee5ebb5e
Autor:
Dianne S Schwarz, Hongliu Ding, Lori Kennington, Jessica T Moore, Janell Schelter, Julja Burchard, Peter S Linsley, Neil Aronin, Zuoshang Xu, Phillip D Zamore
Publikováno v:
PLoS Genetics, Vol 2, Iss 9, p e140 (2006)
Small interfering RNAs (siRNAs), the guides that direct RNA interference (RNAi), provide a powerful tool to reduce the expression of a single gene in human cells. Ideally, dominant, gain-of-function human diseases could be treated using siRNAs that s
Externí odkaz:
https://doaj.org/article/eb326f6c2d474e3fb8c5df12834e5b11
Autor:
Katharina Lambert, Kirsten E. Diggins, Britta E. Jones, Christian Hundhausen, Megan D. Maerz, Anne M. Hocking, Srinath Sanda, Carla J. Greenbaum, Peter S. Linsley, Karen Cerosaletti, Jane H. Buckner
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Elevated levels and enhanced sensing of the pro-inflammatory cytokine interleukin-6 (IL-6) are key features of many autoimmune and inflammatory diseases. To better understand how IL-6 signaling may influence human T cell fate, we investigated the rel
Externí odkaz:
https://doaj.org/article/c773700586e44a7c8cb9899ec2c188f9
Publikováno v:
The Journal of Immunology. 210:888-894
The thymus is an intricate organ consisting of a diverse population of thymic epithelial cells (TECs). Cortical and medullary TECs and their subpopulations have distinct roles in coordinating the development and selection of functionally competent an
Autor:
B. Nelson Chau, Michele A. Cleary, Peter S. Linsley, Michael O. Carleton, Aimee L. Jackson, Aaron N. Chang, Jane Guo, Janell M. Schelter, Soo-yeon Kim, Matthew C. Biery, Sara A. Georges
Supplementary Figure A from Coordinated Regulation of Cell Cycle Transcripts by p53-Inducible microRNAs, miR-192 and miR-215
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cfbb72786007f48eacdca98c832638d
https://doi.org/10.1158/0008-5472.22376024
https://doi.org/10.1158/0008-5472.22376024