Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Peter S Choi"'
Autor:
Ji Li, Peter S Choi, Christine L Chaffer, Katherine Labella, Justin H Hwang, Andrew O Giacomelli, Jong Wook Kim, Nina Ilic, John G Doench, Seav Huong Ly, Chao Dai, Kimberly Hagel, Andrew L Hong, Ole Gjoerup, Shom Goel, Jennifer Y Ge, David E Root, Jean J Zhao, Angela N Brooks, Robert A Weinberg, William C Hahn
Publikováno v:
eLife, Vol 7 (2018)
Alternative splicing of mRNA precursors represents a key gene expression regulatory step and permits the generation of distinct protein products with diverse functions. In a genome-scale expression screen for inducers of the epithelial-to-mesenchymal
Externí odkaz:
https://doaj.org/article/065b7c78b0bc49f4914d3e34a00422d9
Autor:
Brenton R Paolella, William J Gibson, Laura M Urbanski, John A Alberta, Travis I Zack, Pratiti Bandopadhayay, Caitlin A Nichols, Pankaj K Agarwalla, Meredith S Brown, Rebecca Lamothe, Yong Yu, Peter S Choi, Esther A Obeng, Dirk Heckl, Guo Wei, Belinda Wang, Aviad Tsherniak, Francisca Vazquez, Barbara A Weir, David E Root, Glenn S Cowley, Sara J Buhrlage, Charles D Stiles, Benjamin L Ebert, William C Hahn, Robin Reed, Rameen Beroukhim
Publikováno v:
eLife, Vol 6 (2017)
Genomic instability is a hallmark of human cancer, and results in widespread somatic copy number alterations. We used a genome-scale shRNA viability screen in human cancer cell lines to systematically identify genes that are essential in the context
Externí odkaz:
https://doaj.org/article/8eec2bdf4b584beabb46e378e18f1d59
Autor:
Angela N Brooks, Peter S Choi, Luc de Waal, Tanaz Sharifnia, Marcin Imielinski, Gordon Saksena, Chandra Sekhar Pedamallu, Andrey Sivachenko, Mara Rosenberg, Juliann Chmielecki, Michael S Lawrence, David S DeLuca, Gad Getz, Matthew Meyerson
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87361 (2014)
Although recurrent somatic mutations in the splicing factor U2AF1 (also known as U2AF35) have been identified in multiple cancer types, the effects of these mutations on the cancer transcriptome have yet to be fully elucidated. Here, we identified sp
Externí odkaz:
https://doaj.org/article/0ed24c85ef0e4b54b65f5d4ffd3aec84
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107589 (2014)
The Cre/loxP system is a powerful tool for generating conditional genomic recombination and is often used to examine the mechanistic role of specific genes in tumorigenesis. However, Cre toxicity due to its non-specific endonuclease activity has been
Externí odkaz:
https://doaj.org/article/66ccfbbd8ad347928c132c43dc1d948f
Autor:
Thomas G. Brooks, Nicholas F. Lahens, Antonijo Mrčela, Dimitra Sarantopoulou, Soumyashant Nayak, Amruta Naik, Shaon Sengupta, Peter S. Choi, Gregory R. Grant
Simulation of RNA-seq reads is critical in the assessment, comparison, benchmarking, and development of bioinformatics tools. Yet the field of RNA-seq simulators has progressed little in the last decade. To address this need we have developed BEERS2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::252481c4bf4c715c34c63ec0252e2c07
https://doi.org/10.1101/2023.04.21.537847
https://doi.org/10.1101/2023.04.21.537847
Table S1. Mutageneis primers Table S2. shRNA sequences Table S3. Significantly enriched gene sets for SOS1 N233Y vs. SOS1 WT from gene set enrichment analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce92fa246d443855975a11a98fed0b6d
https://doi.org/10.1158/1541-7786.22515864
https://doi.org/10.1158/1541-7786.22515864
Lung adenocarcinomas are characterized by mutations in the receptor tyrosine kinase (RTK)/Ras/Raf pathway, with up to 75% of cases containing mutations in known driver genes. However, the driver alterations in the remaining cases are yet to be determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dab20ebeb7afa2284709bce7eba70759
https://doi.org/10.1158/1541-7786.c.6541206
https://doi.org/10.1158/1541-7786.c.6541206
Autor:
Matthew Meyerson, Andrew D. Cherniack, William C. Hahn, Marios Giannakis, Ashton C. Berger, Zhong Wu, Jin Zhou, Alison M. Taylor, Aviad Tsherniak, Francisca Vazquez, Juliann Shih, Gavin Ha, Yoichiro Mitsuishi, Aruna Ramachandran, Joshua D. Campbell, Galen F. Gao, Joshua M. Francis, Peter S. Choi, Xiaoyang Zhang
Table S1: KLF5 E419Q-gained super-enhancers and the nearest genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57784b466c217131de2705ae4e8dbb36
https://doi.org/10.1158/2159-8290.22533455
https://doi.org/10.1158/2159-8290.22533455
Autor:
Matthew Meyerson, Andrew D. Cherniack, William C. Hahn, Marios Giannakis, Ashton C. Berger, Zhong Wu, Jin Zhou, Alison M. Taylor, Aviad Tsherniak, Francisca Vazquez, Juliann Shih, Gavin Ha, Yoichiro Mitsuishi, Aruna Ramachandran, Joshua D. Campbell, Galen F. Gao, Joshua M. Francis, Peter S. Choi, Xiaoyang Zhang
Figure S1. Super-enhancers near the KLF5 gene are focally amplified in cancer cell lines;Figure S2. The regulatory potential of the KLF5/KLF12 intervening region;Figure S3. Expression level of KLF12, DIS3 and PIBF1 after repression of KLF5 superenhan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bb2cf3f3ecd40c7018c41ed357f9fcf
https://doi.org/10.1158/2159-8290.22533458
https://doi.org/10.1158/2159-8290.22533458
Autor:
Matthew Meyerson, Andrew D. Cherniack, William C. Hahn, Marios Giannakis, Ashton C. Berger, Zhong Wu, Jin Zhou, Alison M. Taylor, Aviad Tsherniak, Francisca Vazquez, Juliann Shih, Gavin Ha, Yoichiro Mitsuishi, Aruna Ramachandran, Joshua D. Campbell, Galen F. Gao, Joshua M. Francis, Peter S. Choi, Xiaoyang Zhang
Table S2: Oligos used in the study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c7f3b0e9b16cd0579e355b125c0a91
https://doi.org/10.1158/2159-8290.22533452.v1
https://doi.org/10.1158/2159-8290.22533452.v1