Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Peter Ruus"'
Autor:
Maria Myzithras, Craig Giragossian, Peter Ruus, Steven Hansel, Rachel Kroe-Barrett, Rajkumar Ganesan, Chandrasena Pamulapati, Danlin Yang, Jennifer Ahlberg, Perez Rocio K, David Joseph, Kelly Coble, Christine Grimaldi, Hua Li, Su-Ellen Brown, M. Lamine Mbow, Ernie L. Raymond, Joseph R. Woska, Gary O. Caviness
Publikováno v:
mAbs
Accurate prediction of the human pharmacokinetics (PK) of a candidate monoclonal antibody from nonclinical data is critical to maximize the success of clinical trials. However, for monoclonal antibodies exhibiting nonlinear clearance due to target-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10aaebb79f89b02bee21a5a9363289b9
https://doi.org/10.1080/19420862.2019.1615345
https://doi.org/10.1080/19420862.2019.1615345
Autor:
Harald Achenbach, Jens Teichert, Robert Hermann, Peter Ruus, Christa Preiss, Rainer Preiss, Tina Tuemmers
Publikováno v:
The Journal of Clinical Pharmacology. 45:313-328
In an open-label, parallel-group study involving 16 patients (8 with severely reduced renal function, 8 with end-stage renal disease needing hemodialysis), the effect of renal function on the pharmacokinetics, metabolism, and safety and of alpha-lipo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a13f3b14acfe2867baff205ffefc53b4
https://doi.org/10.1177/0091270004270792
https://doi.org/10.1177/0091270004270792
Publikováno v:
The Journal of Clinical Pharmacology. 43:1257-1267
R(+)-alpha-lipoic acid is a natural occurring compound that acts as an essential cofactor for certain dehydrogenase complexes. The redox couple alpha-lipoic acid/dihydrolipoic acid possesses potent antioxidant activity. Exogenous racemic alpha-lipoic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec7430bdc6aeeb22cfacd32e49d2804b
https://doi.org/10.1177/0091270003258654
https://doi.org/10.1177/0091270003258654
Autor:
Jeffrey Paul, Norbert G. Knebel, Katharina Erb, Lyette S Richards, Hans‐Peter Cnota, Robert Hermann, Geraldine M. Ferron, Peter Ruus, Steven M. Troy
Publikováno v:
Clinical Pharmacology & Therapeutics. 73:61-70
Background The novel antiepileptic drug retigabine is the first selective M-current potassium channel opener for KCNQ2/3 and KCNQ3/5 channels. Retigabine undergoes phase II metabolism (N-glucuronidation, acetylation) exclusively and renal excretion.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f7e9c08dbe3bef91828792b989d4e7
https://doi.org/10.1067/mcp.2003.12
https://doi.org/10.1067/mcp.2003.12
Autor:
Robert Hermann, Christoph H. Gleiter, Georg Niebch, H.Jörg Wildgrube, Horst Nowak, Peter Ruus
Publikováno v:
European Journal of Pharmaceutical Sciences. 6:27-37
The objective of this study was to determine the impact of prolonged gastric emptying in patients with insulin dependent diabetes mellitus (IDDM) on the bioavailability of the R(+)- and S(-)-thioctic acid (TA) enantiomers. Gastric emptying time (GET)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18335fc69e62ba278142c963cbbd0261
https://doi.org/10.1016/s0928-0987(97)00065-1
https://doi.org/10.1016/s0928-0987(97)00065-1
Autor:
Peter Ruus, H. Riethmüller-Winzen, Robert Hermann, M. Peukert, Georg Niebch, H. O. Borbe, H. Fieger-Büschges, Horst Nowak, Henning Blume
Publikováno v:
European Journal of Pharmaceutical Sciences. 4:167-174
The pharmacokinetics and the absolute bioavailability of the enantiomers of α-lipoic acid (α-LA) from different dosage forms have been studied for the first time in twelve healthy volunteers using a specific enantioselective HPLC assay. Single dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc2bc9b658216a711e00055dbb1ce4a3
https://doi.org/10.1016/0928-0987(95)00045-3
https://doi.org/10.1016/0928-0987(95)00045-3
Autor:
Claudia Pfeiffer, Peter Ruus
Publikováno v:
Drug Discovery and Evaluation: Methods in Clinical Pharmacology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3e4658c978191a34dcfd213a6121703
https://doi.org/10.1007/978-3-540-89891-7_28
https://doi.org/10.1007/978-3-540-89891-7_28
Autor:
Peter Ruus, Robert Hermann
Publikováno v:
BMC News and views. 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6405fb17acddcbe2afcb4a0f4ec550bd
https://doi.org/10.1186/2048-4623-4-s1-op007
https://doi.org/10.1186/2048-4623-4-s1-op007
Autor:
Michael Horowitz, Hartmut Rütten, Reinhard H.A. Becker, Axel Steinsträßer, Martin Lorenz, Peter Ruus, Claudia Pfeiffer
Publikováno v:
Regulatory Peptides. :1-8
ObjectivesTo determine the effects of lixisenatide, a new once-daily (QD) glucagon-like peptide-1 receptor agonist, on postprandial glucose (PPG) and gastric emptying, and the relationship between these effects in patients with type 2 diabetes mellit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d97b23e39052b3fe666fee040fa65fbd