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of 185
pro vyhledávání: '"Peter Rotwein"'
Autor:
Peter Rotwein, Kabita Baral
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-17 (2020)
Abstract Background Recent advances in genetics and genomics present unique opportunities for enhancing our understanding of mammalian biology and evolution through detailed multi-species comparative analysis of gene organization and expression. Yet,
Externí odkaz:
https://doaj.org/article/c48e3d67fd594b98a03f1d4604026d02
Autor:
Kabita Baral, Peter Rotwein
Publikováno v:
Evolutionary Bioinformatics, Vol 16 (2020)
Recent advances in genetics present unique opportunities for enhancing our understanding of human physiology and disease predisposition through detailed analysis of gene structure, expression, and population variation via examination of data in publi
Externí odkaz:
https://doaj.org/article/ed28bdf49a794568b01c0245d06acf74
Autor:
Peter Rotwein
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233081 (2020)
ZMAT2 is among the least-studied of mammalian proteins and genes, even though it is the ortholog of Snu23, a protein involved in pre-mRNA splicing in yeast. Here we have used data from genomic and gene expression repositories to examine the Zmat2 gen
Externí odkaz:
https://doaj.org/article/67aa1340a8194af69953da4e5df8c547
Autor:
Peter Rotwein
Publikováno v:
Bio-Protocol, Vol 9, Iss 1 (2019)
Recent advances in genomics present new opportunities for enhancing knowledge about gene regulation and function across a wide spectrum of organisms and species. Understanding and evaluating this information at the individual gene level is challengin
Externí odkaz:
https://doaj.org/article/11b9bb278d82476ca296555c6b080c28
Autor:
Kabita Baral, Peter Rotwein
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0219155 (2019)
The secreted protein, insulin-like growth factor 2 (IGF2), plays a central role in fetal and prenatal growth and development, and is regulated at the genetic level by parental imprinting, being expressed predominantly from the paternally derived chro
Externí odkaz:
https://doaj.org/article/dcb82efb8a0c4b4d975cb948bdc06a61
Autor:
Peter Rotwein
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189642 (2017)
Insulin-like growth factor 1 (IGF1), a small, secreted peptide growth factor, is involved in a variety of physiological and patho-physiological processes, including somatic growth, tissue repair, and metabolism of carbohydrates, proteins, and lipids.
Externí odkaz:
https://doaj.org/article/1149da5cc2ab45089ed4516e89ac32ae
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e93040 (2014)
Skeletal integrity is dependent on the coordinated actions of bone-forming osteoblasts and bone-resorbing osteoclasts, which recognize and respond to multiple environmental inputs. Here we have studied the roles in bone development and growth of Akt1
Externí odkaz:
https://doaj.org/article/6605e58b1e75433f9b6c6c05919b9dac
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50278 (2012)
Many of the biological effects of growth hormone (GH) are mediated by insulin-like growth factor I (IGF-I), a 70-amino acid secreted peptide whose gene expression is rapidly induced by GH via the Stat5b transcription factor. We previously identified
Externí odkaz:
https://doaj.org/article/c4340d7a6b254a5191ec974022744770
Autor:
Peter Rotwein
Publikováno v:
Mol Cell Endocrinol
Insulin-like growth factor 1 (IGF1) actions are essential for somatic growth and tissue repair. IGF1 gene regulation is controlled by many inputs, with growth hormone playing a major role. In most mammals, the 6-exon IGF1/Igf1 gene produces multiple
Autor:
Peter Rotwein, Kabita Baral
Publikováno v:
Evolutionary Bioinformatics
Recent advances in genetics present unique opportunities for enhancing our understanding of human physiology and disease predisposition through detailed analysis of gene structure, expression, and population variation via examination of data in publi