Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Peter Rippstein"'
Autor:
Naif A.M. Almontashiri, Hsiao-Huei Chen, Ryan J. Mailloux, Takashi Tatsuta, Allen C.T. Teng, Ahmad B. Mahmoud, Tiffany Ho, Nicolas A.S. Stewart, Peter Rippstein, Mary Ellen Harper, Robert Roberts, Christina Willenborg, Jeanette Erdmann, Annalisa Pastore, Heidi M. McBride, Thomas Langer, Alexandre F.R. Stewart
Publikováno v:
Cell Reports, Vol 7, Iss 3, Pp 834-847 (2014)
Mitochondrial production of reactive oxygen species (ROS) affects many processes in health and disease. SPG7 assembles with AFG3L2 into the mAAA protease at the inner membrane of mitochondria, degrades damaged proteins, and regulates the synthesis of
Externí odkaz:
https://doaj.org/article/aebe476dd1c04886a50974f3c1065d37
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52830 (2012)
The mechanisms that ensure the removal of damaged mitochondrial proteins and lipids are critical for the health of the cell, and errors in these pathways are implicated in numerous degenerative diseases. We recently uncovered a new pathway for the se
Externí odkaz:
https://doaj.org/article/ae954a7c6a6144ae9dcbc754b2b8f40a
Publikováno v:
Toxicological Sciences
There are an increasing number of studies indicating that mitochondria are relevant targets in nanomaterial-induced toxicity. However, the underlying mechanisms by which nanoparticles (NPs) interact with these organelles and affect their functions ar
Autor:
Jean da Silva, Skye McBride, Mary-Ellen Harper, Jian Ying Xuan, Marjorie F. Lou, Robert A. deKemp, Chris R. J. Kennedy, Peter Rippstein, Stephanie Thorn, Mona Nemer, Ryan J. Mailloux, Chet E. Holterman, Wael Maharsy
Publikováno v:
Journal of Biological Chemistry. 289:14812-14828
Glutaredoxin-2 (Grx2) modulates the activity of several mitochondrial proteins in cardiac tissue by catalyzing deglutathionylation reactions. However, it remains uncertain whether Grx2 is required to control mitochondrial ATP output in heart. Here, w
Autor:
Majambu Mbikay, Andrew Chen, Fraser W. Scott, Francine Sirois, Charles Gyamera-Acheampong, Gen-Sheng Wang, Peter Rippstein, Michel Chrétien, Janice Mayne
Publikováno v:
Journal of Diabetes. 7:74-84
Background Proprotein convertase subtilisin/kexin-type 9 (PCSK9) downregulates clearance of plasma cholesterol by liver. Its inactivation increases this clearance, reducing cardiovascular risk. However, a lack of PCSK9 could also lead to cholesterol
Autor:
Kathy C. Nguyen, Andrey Massarsky, Ren Abraham, Azam F. Tayabali, Peter Rippstein, Vance L. Trudeau, Thomas W. Moon
Publikováno v:
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 159:10-21
Silver nanoparticles (AgNPs) are present in a multitude of consumer and medical products; however, the toxicity of AgNPs is not fully understood. This research aimed to elucidate the relationship between AgNP cytotoxicity and oxidative stress and dam
SR-BI Undergoes Cholesterol-stimulated Transcytosis to the Bile Canaliculus in Polarized WIF-B Cells
Publikováno v:
Journal of Biological Chemistry. 282:1445-1455
The scavenger receptor BI (SR-BI) is highly expressed in hepatocytes, where it mediates the uptake of lipoprotein cholesterol, promotes the secretion of cholesterol into bile, and protects against atherosclerosis. Despite a strong correlation between
Autor:
Yves De Repentigny, Ron Saulnier, Peter Rippstein, Karen K. Lee, Rashmi Kothary, Wendy B. Macklin
Publikováno v:
Glia. 53:836-844
Recent studies have demonstrated the importance of beta1 integrin in oligodendrocyte maturation in vitro. Similar studies in vivo have been difficult due to the embryonic and perinatal lethality of null mutations in integrin subunits. Here, we have g
Autor:
Araya Anupriwan, Nongnuj Tanphaichitr, Euridice Carmona, Hongbin Xu, Louis Hermo, Peter Rippstein, Prapee Sretarugsa, Michael G. Wade, Prasert Sobhon, Solange Maria da Silva, Wattana Weerachatyanukul
Publikováno v:
Biology of Reproduction. 69:1183-1192
Arylsulfatase A (AS-A) is localized to the sperm surface and participates in sperm-zona pellucida binding. We investigated how AS-A, usually known as an acrosomal enzyme, trafficked to the sperm surface. Immunocytochemistry of the mouse testis confir
Publikováno v:
Biology of Reproduction. 68:610-619
Although FSH up-regulates follicular cell X-linked inhibitor of apoptosis protein (XIAP) expression and suppresses apoptosis in vivo, if these events are coincidental or causally related remains to be investigated. The present study examined the role